Latest Advances in the Effects of Caloric Restriction on Gut Microbiota in Healthy，Aged and Diseased Populations

doi:10.12114/j.issn.1007-9572.2020.00.472

Abstract

Abstract: Caloric restriction（CR） plays a part in promoting health and longevity，delaying aging，and preventing the development of metabolic disorders and age-related diseases. Recent studies have found that gut microbiota play a key role in healthy，aged and diseased hosts，and changes in diet can significantly affect the balance of beneficial and pathogenic bacteria in the gut. CR is one of the most commonly used dietary interventions，whose benefits may be produced via the modification of gut microbiota. This article reviews the latest advances in the effects of CR on gut microbiota in healthy，aged and diseased populations，providing microbiological evidence for clinical application and promotion of CR.

Key words: Caloric restriction, Gut microbiota, Health, Aging, Diseases, Review

摘要： 基金项目：国家自然科学基金面上项目（81973927；81873356）
热量限制可以促进机体健康、延长寿命、延缓衰老、防止代谢紊乱和与年龄相关疾病的发生发展。近年来，研究发现肠道菌群在宿主的健康、衰老和疾病中均发挥了关键作用，饮食的改变可显著影响肠道有益菌和致病菌的平衡。热量限制是最常采用的饮食干预疗法之一，其有益作用可能是通过肠道菌群介导的。本文通过综述热量限制对健康、衰老和疾病状态下机体肠道菌群影响的相关研究进展，以期为热量限制的临床应用和推广提供微生物学证据。

关键词: 热量限制, 肠道菌群, 健康, 衰老, 疾病, 综述

YE Jiamei,ZHONG Dongling,LI Juan, et al. Latest Advances in the Effects of Caloric Restriction on Gut Microbiota in Healthy，Aged and Diseased Populations　[J]. Chinese General Practice, 2021, 24(7): 895-900. DOI: 10.12114/j.issn.1007-9572.2020.00.472.
叶佳美,钟冬灵,李涓等. 热量限制对健康、衰老和疾病机体肠道菌群影响的研究进展[J]. 中国全科医学, 2021, 24(7): 895-900. DOI: 10.12114/j.issn.1007-9572.2020.00.472.

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