Abstract: Background　Baseline blood glucose（GLU），lipid profile and plasma fibrinogen（FBG）can be affected by age and gender.The elderly people are at high risk of stroke.Understanding the association with baseline level changes of GLU，lipid profile and FBG and the changes of age and gender is helpful to do better stroke prevention strategies for elderly people.Objective　To analyze level difference and its clinical significance of baseline GLU，lipid profile and plasma FBG in patients 60 years of age or older with acute ischemic stroke（AIS） from different age groups and genders.Methods　A total of 379 patients admitted to Department of Neurology of Zi Chuan District Hospital in Zibo with diagnosis of AIS from October 2013 to October 2014 were selected as study subjects.Patients were divided into three age groups：60 to 69 years old （139 cases），70 to 79 years old （145 cases） and above 80 years old （95 cases）．Based on gender，patients were divided into male group （169 cases） and female group （210 cases）．The level of GLU，triglyceride （TG），total cholesterol （TC），high-density lipoprotein cholesterol （HDL-C），low-density lipoprotein cholesterol （LDL-C） and FBG levels were detected on admission.Abnormality report rate of lab results mentioned above in different age and gender groups was calculated.Results　The levels of GLU，TG，TC and LDL-C decreased with age （P<0.05），while HDL-C and FBG levels increased with age （P<0.05）．The detection rate of abnormal TG levels decreased with age （P<0.05），and the detection rate of abnormal FBG levels increased with age （P<0.05）．As for differences between genders，GLU，TG，TC，HDL-C and LDL-C levels in female group were higher than those of male group （P<0.05）．Abnormality report rate of TG，TC and LDL-C in female group was higher than those of male group，while of HDL-C was lower than male group （P<0.05）．Conclusion　The levels of GLU，blood lipids，FBG and abnormality report rate of elderly patients with AIS in different age groups and genders are different.We should treat elderly people differently according to their age stages and genders when we do primary and secondary stroke prevention.

Key words: Ischemic stroke, Blood glucose, Lipid profile, Fibrinogen, Age factors, Sex factors

摘要： 背景  基线血糖（GLU）、血脂及血浆纤维蛋白原（FBG）水平是受年龄和性别因素影响的指标，老年人群是脑卒中高发人群，了解老年人群基线GLU、血脂及FBG水平随年龄及性别的变化规律，有助于更好地为老年人群制定个体化的脑卒中预防策略。目的　分析60岁以上急性缺血性脑卒中（AIS）患者不同年龄段及性别间基线GLU、血脂及FBG水平差异及意义。方法　选取2013年10月—2014年10月淄博市淄川区医院神经内科收治的AIS患者379例，依据年龄将其分为60~69岁组（139例）、70~79岁组（145例）及≥80岁组（95例），依据性别将其分为男性组（169例）和女性组（210例），检测GLU、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和FBG水平，并计算不同年龄、性别组各项指标异常检出率。结果　GLU、TG、TC和LDL-C水平随年龄增长呈下降趋势（P<0.05）；HDL-C、FBG水平随年龄增长呈上升趋势（P<0.05）。TG异常检出率随年龄增长呈下降趋势（P<0.05）；FBG异常检出率随年龄增长呈上升趋势（P<0.05）。女性组的GLU、TG、TC、HDL-C、LDL-C水平均高于男性组（P<0.05）。女性组的TG、TC和LDL-C异常检出率均高于男性组，HDL-C异常检出率低于男性组（P<0.05）。结论　不同年龄段及性别的老年AIS患者GLU、血脂及FBG水平及异常检出率存在差异，在对老年人群进行AIS一级和二级预防时，要依据不同年龄段和性别区别对待。

关键词: 缺血性脑卒中, 血糖, 血脂, 纤维蛋白原, 年龄因素, 性别因素