Abstract: Background　In recent years，many children have constipation or/and anal fissure due to eating formula milk and picky eating.Clinical visits due to anal fissure in children are gradually increasing.However，this disease is often ignored because there are few studies or reports about pediatric anal fissure，and children's relatives have insufficient understanding of this disease and even do not know the appropriate specialty to seek healthcare.Objective　To explore the clinical efficacy of external application of honey by analyzing relevant therapeutic indices，and discuss its simplicity of use，providing a new scheme for the treatment of this disease.Methods　This study was implemented from October 2017 to December 2018 in 140 children with anal fissure selected from anorectal outpatients of Jinshan Hospital Affiliated to Fudan University，and from physical examinees of Jinshan Industrial Park Community Health Center，Jinshan Shihua Community Health Center，Caojing Community Health Center，and Jinshanwei Community Health Center.Participants were equally divided into the control group and treatment group by a random number table，70 cases in each group，treated with adjusting the diet，adjusting the diet with application of the honey on the fissure using cotton swabs every evening.The intervention lasted for 2 weeks.Intervention outcome was evaluated by the hematochezia score，FLACC score and fissure healing status.Results　The average hematochezia scores of the treatment group on the 7th and 14th day of treatment was lower than that of the control group（P<0.05）.There were no significant differences in average FLACC score between the two groups before treatment and on the 7th day of treatment（P>0.05）.The average FLACC score of the treatment group on the 14th day of treatment was lower than that of the control group（P<0.05）.The treatment group showed higher fissure healing rate than the control group on the 7th day of treatment〔8.6%（6/70）vs 0〕（χ2=4.353，P=0.037） as well as on the 14th day of treatment〔68.6%（48/70） vs 34.3%（24/70）〕（χ2=16.471，P<0.001）.Conclusion　External application of honey is highly effective for reducing the hematochezia and pain，and promoting the healing of anal fissure，manifesting the features of simple，convenient，effective and inexpensive.

Key words: Fissure in ano, Honey, Child, Treatment outcome, Pain, Hemorrhage

摘要： 背景　近年来随着社会的发展，很多小儿食用配方奶、挑食从而造成大便秘结引发肛裂。临床发现小儿肛裂就诊率逐渐上升，然而国内外针对小儿肛裂的研究及文献报道甚少，家属对该疾病的认识不足，就诊科室不明确，导致该疾病常被忽视。目的　观察蜂蜜外涂治疗小儿肛裂的临床疗效，分析相关疗效指标，探讨该方法的简便性与有效性，为小儿肛裂的临床治疗提供新方案。方法　选取2017年10月—2018年12月在复旦大学附属金山医院肛肠门诊就诊以及在金山工业区社区卫生服务中心、石化社区卫生服务中心、漕泾社区卫生服务中心、金山卫镇社区卫生服务中心体检并发现患有肛裂的患儿140例。采用随机数字表法将患儿分为对照组和治疗组，各70例。对照组患儿采用饮食调整，治疗组在对照组的基础上每晚用棉签蘸取蜂蜜外涂裂口。干预时间为2周。干预前后评价便血、疼痛评分及裂口愈合情况。结果　治疗组治疗第7、14天便血评分低于对照组（P<0.05）。两组治疗前、治疗第7天疼痛评分比较，差异均无统计学意义（P>0.05）；治疗组治疗第14天疼痛评分低于对照组（P<0.05）。治疗第7天，治疗组裂口愈合率为8.6%（6/70），高于对照组的0（χ2=4.353，P=0.037）。治疗第14天，治疗组裂口愈合率为68.6%（48/70），高于对照组的34.3%（24/70）（χ2=16.471，P<0.001）。结论　蜂蜜外涂治疗小儿肛裂引起的出血、疼痛及裂口愈合方面疗效显著，充分发挥“简、便、效、廉”的中医药治疗特色。

关键词: 肛裂, 蜂蜜, 儿童, 治疗结果, 疼痛, 出血