Treatment of Chronic Kidney Disease with Hyperuricemia：Current Situation and Challenges

doi:10.12114/j.issn.1007-9572.2019.00.028

Abstract

Abstract: Chronic kidney disease is commonly associated with hyperuricemia.Hyperuricemia is an independent risk factor for the progression of chronic kidney disease.Decreased glomerular filtration rate and increased adverse drug reactions can affect the choice of urate-lowering therapies for patients with chronic kidney disease.In this paper，with referencing to the related guidelines，we reviewed the current situation and progress of commonly used urate-lowering drugs，and put forward ways for overcoming the challenges in the application of new drugs for lowering uric acid and the management of uric acid，gout，tophus in chronic kidney disease with hyperuricemia.

Key words: Chronic kidney disease, Hyperuricemia, Uric acid, Gout, Glomerular filtration rate, Current situation, Challenges

摘要： 慢性肾脏病常合并高尿酸血症，高尿酸血症是慢性肾脏病进展的独立危险因素，由于肾小球滤过率下降、药物不良反应增加等因素将会影响慢性肾脏病患者降尿酸方案的选择。本文结合目前指南内容对常用药物的使用现状与进展进行综述，对新药物的应用、慢性肾脏病合并高尿酸血症的尿酸、痛风、痛风石的管理等挑战提出思考。

关键词: , 慢性肾脏病；高尿酸血症；尿酸；痛风；肾小球滤过率；现状；挑战

ZHANG Xiongfeng,LI Zhengsheng,ZHONG Qin, et al. Treatment of Chronic Kidney Disease with Hyperuricemia：Current Situation and Challenges　[J]. Chinese General Practice, 2019, 22(17): 2020-2024. DOI: 10.12114/j.issn.1007-9572.2019.00.028.
张雄峰,李正胜,钟琴等. 慢性肾脏病合并高尿酸血症治疗的现状与挑战[J]. 中国全科医学, 2019, 22(17): 2020-2024. DOI: 10.12114/j.issn.1007-9572.2019.00.028.

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