Abstract: Gastric cancer is one of the most common malignancies，whose incidence ranks the second among all cancers in China.Many factors participate in the development of gastric cancer，of them，Helicobacter pylori is regarded as the most important carcinogen by WHO.We reviewed the recent studies concerning gastric cancer and Helicobacter pylori strain specificity，in particular，examined the internal relationship of gastric cancer with several Helicobacter pylori proteins（CagA，VacA，outer membrane protein，dupA） based on analyzing in vitro studies and animal model studies.Our findings suggest that the specificity of Helicobacter pylori strains in different regions may lead to the geographical differences in the incidence of gastric cancer.

Key words: Stomach neoplasms, Helicobacter pylori, Strain specificity, Geographical difference

摘要： 胃癌是最常见的癌症之一，其发病率在我国居第二位。胃癌的发生是多因素共同作用的结果，而幽门螺杆菌是WHO认定的胃癌的首要致癌因子。本文归纳了幽门螺杆菌菌株特异性与胃癌的相关性，通过总结细胞实验和动物模型，揭示了CagA、VacA、外膜蛋白、dupA等因子与胃癌发病的内在联系，并提出不同地区幽门螺杆菌菌株特异性可能是导致胃癌发病率地理性差异的重要原因。

关键词: 胃肿瘤, 幽门螺杆菌, 菌株特异性, 地理性差异