Abstract:  Lung cancer is the most common cancer and the leading cause of cancer-related deaths worldwide.With the aging of population and changes in eating habits，the incidence of diabetes mellitus in recent years increased year by year.The phenomenon of coexistence of lung cancer and diabetes mellitus in the same individual is not infrequent.Studies have shown that diabetes and glucose-lowering therapies can influence the risk and prognosis of lung cancer，but its specific impact and mechanism are not yet fully clear.Based on the review of the relevant literature，we summarized the epidemiological characteristics and common risk factors of both lung cancer and diabetes mellitus，impact of diabetes and glucose-lowering drugs on lung cancer and the relative mechanism.

Key words: Lung neoplasms, Diabetes mellitus, Prognosis, Glucose-lowering drugs

摘要： 肺癌是当前世界范围内发病率及肿瘤相关病死率最高的恶性肿瘤。随着人口老龄化及饮食习惯的改变，近年来糖尿病的发病率逐年上升。目前两病共存的现象并不少见。糖尿病和降糖药物均可能对肺癌的发病风险及预后产生影响，但其具体的影响及相关机制尚未完全明确。本文从糖尿病和肺癌两病的流行病学特点、共同高危因素、糖尿病及降糖药物对肺癌的影响和机制等方面对相关研究进展进行综述。

关键词: 肺肿瘤, 糖尿病, 预后, 降糖药物