Abstract: As the population is deeply ageing, osteoporosis and its complications such as fractures have become a serious public health problem. According to the mechanism of action, currently available potent osteoporosis treatments primarily include bone resorption inhibitors, bone formation promoters, and dual-action agents. However, monotherapy often fails to achieve long-term therapeutic effects for osteoporosis. Consequently, sequential therapy with multiple drugs has emerged as an inevitable trend in osteoporosis treatment strategies. This review systematically synthesizes research advances in sequential therapy for osteoporosis, aiming to provide reference for the rational treatment of the disease.

Key words: Osteoporosis, Sequential therapy, Bone formation promoter, Bone resorption inhibitor, Review

摘要： 随着人口步入深度老龄化，骨质疏松症及其引发的骨折等一系列并发症已成为严重的公共健康问题。按照作用机制，目前强有效的骨质疏松症治疗药物主要包括骨吸收抑制剂、骨形成促进剂和双重作用药物等，但单一药物治疗常难以达到长期治疗骨质疏松症的效果。序贯治疗通过不同作用机制药物的策略性转换，旨在实现可持续的保护作用，并减少短效药物停药后骨量快速流失的风险，已成为长程管理的必然选择。但当前该策略仍面临最佳序贯方案循证医学证据不足、转换时机缺乏标准化以及长期安全性有待验证等挑战。本文系统综述骨质疏松症序贯治疗的最新研究进展，以期为临床制订精准、有效的长程治疗策略提供参考依据。

关键词: 骨质疏松, 序贯治疗, 骨形成促进剂, 骨吸收抑制剂, 综述