Abstract: Background　Community pharmacy has significant advantages in curbing medication misuse and managing chronic diseases. Nevertheless，pharmacists encounter challenges such as complex job duties，inadequate professional knowledge，and low public awareness. Under the background of government support for innovating and expanding pharmacists'roles，the healthcare alliance has emerged as an ideal solution to the dilemma in community pharmacy. Objective　This research devote to establish a community pharmacy studio to enhance the quality of community pharmacy services and the outcomes of chronic disease management based on the healthcare alliance model. Methods　Three randomized controlled trials were implemented in three communities within a healthcare alliance from April 2023 to March 2024，while all control groups served as negative controls. In Trial one，254 healthcare professionals were randomly and equally divided into two groups. The experimental group received pharmaceutical literacy training，after which the outcomes were compared with those of the control group. In Trial two，540 residents were randomly divided into two groups，the experimental group received services from the community pharmacy studio. Pharmaceutical literacy，medication adherence，pharmacist recognition，and service satisfaction were compared between the two groups. In Trial three，118 chronic disease patients were randomly divided into two groups. The experimental group received individualized medication guidance，and the rates of chronic disease indicator control were compared between the two groups. Data were collected through questionnaires，interviews，and medical record reviews and analyzed by SPSS 24.0 software. Results　Survey results indicated that the proportion of participants with high pharmaceutical literacy in the experimental group（86.61%，110 /127）was significantly higher than in the control group（68.50%，87/127），showing a statistically significant difference（χ2 =11.966，P<0.01）. The research find that the experimental group had a higher proportion of residents（76.30%）with high pharmaceutical literacy compared to the control group（50.37%）（P<0.001），according to comprehensive assessment of community residents' pharmaceutical literacy and service satisfaction. Additionally，the proportion of community residents exhibiting high medication adherence was higher in the experimental group（81.48%）compared to the control group（68.52%）（P<0.01）. Furthermore，96.67% of respondents in the experimental group were satisfied with the pharmacy studio. The degree of satisfaction was significantly higher than that in the control group（75.19%）（P<0.001）. Also，the experimental group had a higher proportion of residents（94.44%）recognizing the professional the pharmacist team compared to the control group（87.78%）（P<0.01）. Conclusion　Supported by healthcare alliance，the community pharmacy studio model，effectively overcame the challenges of community pharmacy development，enhanced the quality of pharmacy services，improved outcomes of patient disease management，and set new standards for the future of community pharmacy. This model provides valuable insights and practical experience for the development and innovation of community pharmacy services in China.

Key words: Pharmacy, Community pharmacy, Healthcare alliance, Optimization of service efficiency, Medication adherence, Management of chronic disease

摘要： 背景　社区药学通过遏制药物滥用、慢性病管理等展现显著效益，但药师面临工作繁杂、专业素养不足、公众认知低等问题。我国政府支持药师职能创新与拓展，医联体模式成为解决社区药学困境的理想选择。目的　本研究旨在创建一个基于医联体模式的社区药学工作室提升社区药学服务质量与慢病管理效果。方法　2023年4月—2024年3月，团队在医联体内3个社区开展了三项随机对照试验，对照组均为阴性对照。试验一：254名医药护随机均分为两组，试验组接受药学素养提升培训，比较两组培训效果。试验二：540名社区居民随机均分为两组，试验组接受社区药学工作室服务，比较两组药学素养、用药依从性、药师认可度及服务满意度。试验三：118名慢性病患者随机均分为两组，试验组接受个体化用药指导，比较两组慢病指标达标率。数据通过问卷、访谈和病历审查收集，使用SPSS 24.0软件进行分析。结果　医药护药学素养调研结果显示，试验组高药学素养的比例（86.61%，110/127），高于对照组（68.50%，87/127）（χ2=11.966，P<0.01）。社区居民药学素养及服务满意度综合评估：试验组中居民药学素养较高的比例（76.30%），高于对照组（50.37%）（P<0.001）。试验组用药依从性高的社区居民比例（81.48%）高于对照组（68.52%）（P<0.01）。试验组96.67%的受访者对药学工作室满意，高于对照组（75.19%）（P<0.001）。试验组居民对药师团队的专业知识给予认可评价比例为94.44%，高于对照组（87.78%）（P<0.01）。结论　医联体支持下的社区药学工作室模式有效解决了社区药学发展的瓶颈，提升了药学服务质量与患者疾病管理效果，为社区药学未来设立了新标准。该模式为我国社区药学服务的发展与创新提供了宝贵经验。

关键词: 药学, 社区药学, 医联体, 服务效能优化, 服药依从性, 慢性病管理