Chinese General Practice ›› 2024, Vol. 27 ›› Issue (15): 1796-1801.DOI: 10.12114/j.issn.1007-9572.2024.0002

Special Issue: 指南/共识最新文章合集 美国预防临床服务指南工作组(USPSTF)指南解读系列

• USPSTF Recommendations Interpretation(4) • Previous Articles     Next Articles

Interpretation of Screening for Lipid Disorders in Children and Adolescents: U.S. Preventive Services Task Force Recommendation Statement

  

  1. 1. Department of Pediastrics, Peking University First Hospital, Beijing 100034, China
    2. Department of General Practice, Peking University First Hospital, Beijing 100034, China
    3. Department of Clinical Laboratory, Peking University First Hospital, Beijing 100034, China
  • Received:2023-12-11 Revised:2024-01-25 Published:2024-05-20 Online:2024-02-28
  • Contact: YAN Hui
  • About author:
    LIU Wenjun and YAO Mi are co-first authors

2023年美国预防临床服务指南工作组《儿童和青少年血脂异常筛查推荐声明》解读

  

  1. 1.100034 北京市,北京大学第一医院儿童医学中心
    2.100034 北京市,北京大学第一医院全科医学科
    3.100034 北京市,北京大学第一医院检验科
  • 通讯作者: 闫辉
  • 作者简介:
    刘文郡和姚弥为共同第一作者
    作者贡献:刘文郡负责论文的撰写和修订;姚弥负责提出文章思路、指导文章撰写、论文修订;荆冠宁、闫存玲负责提出指导意见;闫辉负责提出指导性意见,并确认论文最终版,对文章负责。
  • 基金资助:
    2022年度北京大学第一医院院内交叉临床研究专项(2022CR22)

Abstract:

Dyslipidemia due to genetic and multifactorial dyslipidemia has a predisposition to early-onset atherosclerotic cardiovascular disease (ASCVD), and consensus and guidelines regarding lipid lowering in adults are well established, but the benefits of lipid screening and treatment in childhood and adolescence for this population are not well established. The United States Preventive Medicine Task Force (USPSTF) issued the Recommendation Statement: Screening for Dyslipidemia in Children and Adolescents based on a systematic review of evidence with meta-analysis conducted in a large number of randomized controlled trials, large cohort studies in European and American countries, with the aim of assessing evidences whether initiation of lipid screening and early initiation of treatment in childhood and adolescence has long-term benefits for this population. This article provides a detailed interpretation of the guideline, which aims to provide reference to clinical healthcare workers to improve the understanding of dyslipidaemia in children and to decide whether to screen them with a view to reducing the incidence of cardiovascular disease in adulthood.

Key words: Dyslipidemias, Child, Adolescent, Screening, United States Preventive Medicine Task Force

摘要:

家族性高胆固醇血症和多因素所致血脂异常是导致儿童期血脂异常的重要原因,而儿童期血脂异常可能导致早发动脉粥样硬化性心血管疾病甚至威胁生命。已有众多指南和声明提出不同的儿童和青少年时期血脂筛查策略。2023年美国预防临床服务指南工作组(USPSTF)针对儿童家族性高胆固醇血症及多因素血脂异常筛查的利弊进行了系统综述,并发布《儿童和青少年血脂异常筛查推荐声明》,目前尚无充足的证据评估针对20岁以下儿童青少年血脂异常筛查的益处或危害,呼吁对此开展进一步深入研究,并建议临床医生根据自己的判断决定是否进行筛查。

关键词: 血脂异常, 儿童, 青少年, 筛查, 美国预防临床服务指南工作组