Chinese General Practice ›› 2023, Vol. 26 ›› Issue (14): 1709-1715.DOI: 10.12114/j.issn.1007-9572.2022.0750
• Original Research • Previous Articles Next Articles
Received:
2022-08-12
Revised:
2022-11-19
Published:
2023-05-15
Online:
2022-12-02
Contact:
ZHONG Qiuan
通讯作者:
钟秋安
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0750
组别 | 例数 | 性别(男/女) | 年龄(岁) | 民族〔n(%)〕 | 受教育程度〔n(%)〕 | SBP(mm Hg) | DBP(mm Hg) | 吸烟〔n(%)〕 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
汉族 | 其他 | 初中及以下 | 高中及以上 | 从不吸烟 | 曾经吸烟 | 当前吸烟 | ||||||
CIMT正常组 | 693 | 202/491 | 56.0±10.2 | 451(65.1) | 242(34.9) | 616(88.9) | 77(11.1) | 137±20 | 79±13 | 547(78.9) | 63(9.1) | 83(12.0) |
CIMT增厚组 | 45 | 22/23 | 63.5±7.6 | 20(44.4) | 25(55.6) | 41(91.1) | 4(8.9) | 159±24 | 83±15 | 27(60.0) | 7(15.6) | 11(24.4) |
检验统计量值 | 7.789a | 4.847 | 7.793a | 0.213a | 7.231 | 2.147 | 8.965a | |||||
P值 | 0.005 | <0.001 | 0.005 | 0.644 | <0.001 | 0.032 | 0.011 | |||||
组别 | 饮酒〔n(%)〕 | 颈总动脉内径(mm) | BMI(kg/m2) | LDL-C(mmol/L) | HDL-C(mmol/L) | TG〔M(P25,P75),mmol/L〕 | TC(xmmol/L) | ACR〔M(P25,P75),mg/g〕 | eGFR〔ml·min-1·(1.73 m2)-1〕 | |||
从不饮酒 | 曾经饮酒 | 当前饮酒 | ||||||||||
CIMT正常组 | 349(50.4) | 95(13.7) | 249(35.9) | 6.5±0.8 | 23.6±3.2 | 3.0±0.9 | 1.6±0.4 | 1.6(1.1,2.2) | 5.4±1.0 | 7.6(3.9,15.1) | 88.8±16.3 | |
CIMT增厚组 | 20(44.4) | 4(8.9) | 21(46.7) | 7.4±0.8 | 22.8±3.3 | 3.0±0.8 | 1.6±0.5 | 1.6(1.0,2.1) | 5.8±1.0 | 13.8(9.0,39.3) | 85.4±12.9 | |
检验统计量值 | 2.358a | 7.152 | 1.635 | 0.196 | 0.403 | 0.402b | 3.095 | 5.157b | 1.376 | |||
P值 | 0.307 | <0.001 | 0.102 | 0.844 | 0.686 | 0.687 | 0.002 | <0.001 | 0.169 | |||
组别 | LPA〔M(P25,P75),mg/L〕 | ICAM-1〔M(P25,P75),μg/L〕 | VCAM-1〔M(P25,P75),μg/L〕 | ApoA/ApoB | CRP〔M(P25,P75),mg/L〕 | ALB〔M(P25,P75),mg/L〕 | GLU(mmol/L) | 糖尿病〔n(%)〕 | ALT〔M(P25,P75),U/L〕 | AST〔M(P25,P75),U/L〕 | PHYMET〔M(P25,P75),MET-min/w〕 | |
CIMT正常组 | 135.0(64.8,282.7) | 78.1(52.8,127.0) | 225.2(170.2,299.7) | 1.7±0.6 | 0.9(0.4,1.9) | 9.1(4.7,19.3) | 5.8±1.5 | 61(8.8) | 11.8(8.9,17.0) | 24.0(20.9,29.0) | 5 593(3 564,8 319) | |
CIMT增厚组 | 229.0(117.0,284.0) | 78.1(50.4,150.5) | 298.0(216.0,352.3) | 1.5±0.7 | 1.5(0.9,2.6) | 16.1(10.5,46.0) | 6.1±1.7 | 6(13.3) | 12.0(9.8,18.0) | 26.0(22.9,33.1) | 7 479(3 885,13 146) | |
检验统计量值 | 2.461b | 0.200b | 3.341b | 1.704 | 3.213b | 4.014b | 1.183 | 1.051a | 0.807b | 1.676b | 2.451b | |
P值 | 0.013 | 0.841 | <0.001 | 0.044 | <0.001 | <0.001 | 0.237 | 0.305 | 0.420 | 0.094 | 0.014 |
Table 1 Comparison of general data and cervical color ultrasound results between the two groups
组别 | 例数 | 性别(男/女) | 年龄(岁) | 民族〔n(%)〕 | 受教育程度〔n(%)〕 | SBP(mm Hg) | DBP(mm Hg) | 吸烟〔n(%)〕 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
汉族 | 其他 | 初中及以下 | 高中及以上 | 从不吸烟 | 曾经吸烟 | 当前吸烟 | ||||||
CIMT正常组 | 693 | 202/491 | 56.0±10.2 | 451(65.1) | 242(34.9) | 616(88.9) | 77(11.1) | 137±20 | 79±13 | 547(78.9) | 63(9.1) | 83(12.0) |
CIMT增厚组 | 45 | 22/23 | 63.5±7.6 | 20(44.4) | 25(55.6) | 41(91.1) | 4(8.9) | 159±24 | 83±15 | 27(60.0) | 7(15.6) | 11(24.4) |
检验统计量值 | 7.789a | 4.847 | 7.793a | 0.213a | 7.231 | 2.147 | 8.965a | |||||
P值 | 0.005 | <0.001 | 0.005 | 0.644 | <0.001 | 0.032 | 0.011 | |||||
组别 | 饮酒〔n(%)〕 | 颈总动脉内径(mm) | BMI(kg/m2) | LDL-C(mmol/L) | HDL-C(mmol/L) | TG〔M(P25,P75),mmol/L〕 | TC(xmmol/L) | ACR〔M(P25,P75),mg/g〕 | eGFR〔ml·min-1·(1.73 m2)-1〕 | |||
从不饮酒 | 曾经饮酒 | 当前饮酒 | ||||||||||
CIMT正常组 | 349(50.4) | 95(13.7) | 249(35.9) | 6.5±0.8 | 23.6±3.2 | 3.0±0.9 | 1.6±0.4 | 1.6(1.1,2.2) | 5.4±1.0 | 7.6(3.9,15.1) | 88.8±16.3 | |
CIMT增厚组 | 20(44.4) | 4(8.9) | 21(46.7) | 7.4±0.8 | 22.8±3.3 | 3.0±0.8 | 1.6±0.5 | 1.6(1.0,2.1) | 5.8±1.0 | 13.8(9.0,39.3) | 85.4±12.9 | |
检验统计量值 | 2.358a | 7.152 | 1.635 | 0.196 | 0.403 | 0.402b | 3.095 | 5.157b | 1.376 | |||
P值 | 0.307 | <0.001 | 0.102 | 0.844 | 0.686 | 0.687 | 0.002 | <0.001 | 0.169 | |||
组别 | LPA〔M(P25,P75),mg/L〕 | ICAM-1〔M(P25,P75),μg/L〕 | VCAM-1〔M(P25,P75),μg/L〕 | ApoA/ApoB | CRP〔M(P25,P75),mg/L〕 | ALB〔M(P25,P75),mg/L〕 | GLU(mmol/L) | 糖尿病〔n(%)〕 | ALT〔M(P25,P75),U/L〕 | AST〔M(P25,P75),U/L〕 | PHYMET〔M(P25,P75),MET-min/w〕 | |
CIMT正常组 | 135.0(64.8,282.7) | 78.1(52.8,127.0) | 225.2(170.2,299.7) | 1.7±0.6 | 0.9(0.4,1.9) | 9.1(4.7,19.3) | 5.8±1.5 | 61(8.8) | 11.8(8.9,17.0) | 24.0(20.9,29.0) | 5 593(3 564,8 319) | |
CIMT增厚组 | 229.0(117.0,284.0) | 78.1(50.4,150.5) | 298.0(216.0,352.3) | 1.5±0.7 | 1.5(0.9,2.6) | 16.1(10.5,46.0) | 6.1±1.7 | 6(13.3) | 12.0(9.8,18.0) | 26.0(22.9,33.1) | 7 479(3 885,13 146) | |
检验统计量值 | 2.461b | 0.200b | 3.341b | 1.704 | 3.213b | 4.014b | 1.183 | 1.051a | 0.807b | 1.676b | 2.451b | |
P值 | 0.013 | 0.841 | <0.001 | 0.044 | <0.001 | <0.001 | 0.237 | 0.305 | 0.420 | 0.094 | 0.014 |
变量 | β | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
SBPa | 0.031 | 0.009 | 11.864 | 0.001 | 1.032(1.013,1.050) |
TCb | 0.444 | 0.202 | 4.831 | 0.028 | 1.558(1.049,2.315) |
PHYMET | 0.800 | 0.279 | 8.222 | 0.004 | 2.226(1.289,3.844) |
CRP | 0.380 | 0.172 | 4.881 | 0.027 | 1.462(1.043,2.050) |
超重肥胖 | -0.731 | 0.404 | 3.274 | 0.070 | 0.481(0.218,1.063) |
ACR | 0.279 | 0.147 | 3.602 | 0.057 | 1.321(0.991,1.761) |
LPA | 0.345 | 0.207 | 2.778 | 0.095 | 1.412(0.941,2.118) |
VCAM-1 | 0.743 | 0.481 | 2.386 | 0.122 | 2.102(0.819,5.393) |
肾功能 | -0.685 | 0.416 | 2.711 | 0.100 | 0.504(0.223,1.139) |
ApoA/ApoB | -0.634 | 0.351 | 3.263 | 0.071 | 0.531(0.267,1.055) |
Table 2 Multivariate Logistic regression analysis of influencing factors of the thickening of carotid intima-media thickness
变量 | β | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
SBPa | 0.031 | 0.009 | 11.864 | 0.001 | 1.032(1.013,1.050) |
TCb | 0.444 | 0.202 | 4.831 | 0.028 | 1.558(1.049,2.315) |
PHYMET | 0.800 | 0.279 | 8.222 | 0.004 | 2.226(1.289,3.844) |
CRP | 0.380 | 0.172 | 4.881 | 0.027 | 1.462(1.043,2.050) |
超重肥胖 | -0.731 | 0.404 | 3.274 | 0.070 | 0.481(0.218,1.063) |
ACR | 0.279 | 0.147 | 3.602 | 0.057 | 1.321(0.991,1.761) |
LPA | 0.345 | 0.207 | 2.778 | 0.095 | 1.412(0.941,2.118) |
VCAM-1 | 0.743 | 0.481 | 2.386 | 0.122 | 2.102(0.819,5.393) |
肾功能 | -0.685 | 0.416 | 2.711 | 0.100 | 0.504(0.223,1.139) |
ApoA/ApoB | -0.634 | 0.351 | 3.263 | 0.071 | 0.531(0.267,1.055) |
变量 | β(95%CI) | SE值 | t值 | P值 |
---|---|---|---|---|
SBPa | 0.017(0.009,0.025) | 0.004 | 4.166 | <0.001 |
TCb | 0.020(0.003,0.038) | 0.009 | 2.308 | 0.021 |
PHYMET | 0.022(0.002,0.041) | 0.010 | 2.119 | 0.034 |
吸烟情况 | ||||
曾经吸烟 | 0.047(-0.022,0.117) | 0.036 | 1.136 | 0.182 |
当前吸烟 | 0.076(0.011,0.141) | 0.033 | 2.305 | 0.021 |
CRP | 0.010(-0.003,0.023) | 0.007 | 1.462 | 0.144 |
ACR | 0.013(-0.001,0.023) | 0.007 | 1.771 | 0.077 |
LPA | 0.007(-0.007,0.021) | 0.007 | 1.015 | 0.311 |
ApoA/ApoB | -0.017(-0.043,0.008) | 0.013 | 1.337 | 0.182 |
饮酒情况 | ||||
曾经饮酒 | 0.028(-0.018,0.074) | 0.023 | 1.199 | 0.231 |
当前饮酒 | 0.020(-0.017,0.057) | 0.019 | 1.072 | 0.284 |
GLU | 0.057(-0.025,0.139) | 0.042 | 1.357 | 0.175 |
糖尿病一级家族史 | 0.042(-0.018,0.102) | 0.031 | 1.380 | 0.168 |
Table 3 Multiple linear regression analysis of the factors influencing carotid intima-media thickness
变量 | β(95%CI) | SE值 | t值 | P值 |
---|---|---|---|---|
SBPa | 0.017(0.009,0.025) | 0.004 | 4.166 | <0.001 |
TCb | 0.020(0.003,0.038) | 0.009 | 2.308 | 0.021 |
PHYMET | 0.022(0.002,0.041) | 0.010 | 2.119 | 0.034 |
吸烟情况 | ||||
曾经吸烟 | 0.047(-0.022,0.117) | 0.036 | 1.136 | 0.182 |
当前吸烟 | 0.076(0.011,0.141) | 0.033 | 2.305 | 0.021 |
CRP | 0.010(-0.003,0.023) | 0.007 | 1.462 | 0.144 |
ACR | 0.013(-0.001,0.023) | 0.007 | 1.771 | 0.077 |
LPA | 0.007(-0.007,0.021) | 0.007 | 1.015 | 0.311 |
ApoA/ApoB | -0.017(-0.043,0.008) | 0.013 | 1.337 | 0.182 |
饮酒情况 | ||||
曾经饮酒 | 0.028(-0.018,0.074) | 0.023 | 1.199 | 0.231 |
当前饮酒 | 0.020(-0.017,0.057) | 0.019 | 1.072 | 0.284 |
GLU | 0.057(-0.025,0.139) | 0.042 | 1.357 | 0.175 |
糖尿病一级家族史 | 0.042(-0.018,0.102) | 0.031 | 1.380 | 0.168 |
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