Chinese General Practice ›› 2022, Vol. 25 ›› Issue (20): 2457-2461.DOI: 10.12114/j.issn.1007-9572.2022.0089
Special Issue: 内分泌代谢性疾病最新文章合集; 肥胖最新文章合集
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Received:
2021-12-23
Revised:
2022-03-01
Published:
2022-07-15
Online:
2022-03-24
Contact:
Lianxi LI
About author:
通讯作者:
李连喜
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0089
项目 | T2DM无肥胖组(n=1 609) | T2DM肥胖组(n=1 414) | 检验统计量值 | P值 |
---|---|---|---|---|
年龄(岁) | 59±13 | 58±13 | 2.110a | 0.441 |
性别(男/女) | 904/705 | 816/598 | 0.713b | 0.398 |
糖尿病病程〔M(P25,P75),月〕 | 84(16,144) | 72(24,132) | -0.600 | 0.879 |
吸烟史〔n(%)〕 | 466(29.0) | 426(30.1) | 0.491b | 0.483 |
饮酒史〔n(%)〕 | 231(14.4) | 255(18.0) | 7.542b | 0.006 |
高血压病史〔n(%)〕 | 735(45.7) | 857(60.6) | 67.274b | <0.001 |
降压药用药史〔n(%)〕 | 650(40.4) | 805(56.9) | 82.401b | <0.001 |
收缩压(mm Hg) | 130±17 | 134±17 | 6.455a | <0.001 |
舒张压(mm Hg) | 79±9 | 82±10 | 8.681a | <0.001 |
腰臀比 | 0.89±0.06 | 0.94±0.06 | 22.861a | <0.001 |
FPG〔M(P25,P75),mmol/L〕 | 7.53(6.00,9.65) | 7.91(6.51,9.89) | -4.152 | <0.001 |
2 hPG〔M(P25,P75),mmol/L〕 | 13.14(9.43,16.49) | 13.93(10.88,17.05) | -5.686 | <0.001 |
Scr〔M(P25,P75),μmol/L〕 | 65(54,78) | 68(57,82) | -4.073 | 0.007 |
HbA1c(%) | 9.25±2.52 | 9.02±2.23 | 2.641a | 0.018 |
空腹C肽〔M(P25,P75),μmol/L〕 | 1.37(0.76,2.02) | 1.98(1.33,2.83) | -16.444 | <0.001 |
餐后2 hC肽〔M(P25,P75),μmol/L〕 | 2.96(1.48,4.80) | 4.29(2.72,5.65) | -14.447 | <0.001 |
TG〔M(P25,P75),mmol/L〕 | 1.22(0.86,1.78) | 1.73(1.21,2.49) | -16.610 | <0.001 |
TC(mmol/L) | 4.63±1.15 | 4.78±1.12 | 3.622a | <0.001 |
HDL(mmol/L) | 1.18±0.33 | 1.04±0.27 | 12.658a | <0.001 |
LDL(mmol/L) | 3.04±0.98 | 3.13±0.90 | 2.617a | 0.007 |
ALT〔M(P25,P75),U/L〕 | 17(12,25) | 23(15,37) | -11.595 | <0.001 |
血尿酸〔M(P25,P75),μmol/L〕 | 291(241,348) | 337(276,397) | -12.760 | <0.001 |
Table 1 Comparison of general clinical features between T2DM patients without and with obesity
项目 | T2DM无肥胖组(n=1 609) | T2DM肥胖组(n=1 414) | 检验统计量值 | P值 |
---|---|---|---|---|
年龄(岁) | 59±13 | 58±13 | 2.110a | 0.441 |
性别(男/女) | 904/705 | 816/598 | 0.713b | 0.398 |
糖尿病病程〔M(P25,P75),月〕 | 84(16,144) | 72(24,132) | -0.600 | 0.879 |
吸烟史〔n(%)〕 | 466(29.0) | 426(30.1) | 0.491b | 0.483 |
饮酒史〔n(%)〕 | 231(14.4) | 255(18.0) | 7.542b | 0.006 |
高血压病史〔n(%)〕 | 735(45.7) | 857(60.6) | 67.274b | <0.001 |
降压药用药史〔n(%)〕 | 650(40.4) | 805(56.9) | 82.401b | <0.001 |
收缩压(mm Hg) | 130±17 | 134±17 | 6.455a | <0.001 |
舒张压(mm Hg) | 79±9 | 82±10 | 8.681a | <0.001 |
腰臀比 | 0.89±0.06 | 0.94±0.06 | 22.861a | <0.001 |
FPG〔M(P25,P75),mmol/L〕 | 7.53(6.00,9.65) | 7.91(6.51,9.89) | -4.152 | <0.001 |
2 hPG〔M(P25,P75),mmol/L〕 | 13.14(9.43,16.49) | 13.93(10.88,17.05) | -5.686 | <0.001 |
Scr〔M(P25,P75),μmol/L〕 | 65(54,78) | 68(57,82) | -4.073 | 0.007 |
HbA1c(%) | 9.25±2.52 | 9.02±2.23 | 2.641a | 0.018 |
空腹C肽〔M(P25,P75),μmol/L〕 | 1.37(0.76,2.02) | 1.98(1.33,2.83) | -16.444 | <0.001 |
餐后2 hC肽〔M(P25,P75),μmol/L〕 | 2.96(1.48,4.80) | 4.29(2.72,5.65) | -14.447 | <0.001 |
TG〔M(P25,P75),mmol/L〕 | 1.22(0.86,1.78) | 1.73(1.21,2.49) | -16.610 | <0.001 |
TC(mmol/L) | 4.63±1.15 | 4.78±1.12 | 3.622a | <0.001 |
HDL(mmol/L) | 1.18±0.33 | 1.04±0.27 | 12.658a | <0.001 |
LDL(mmol/L) | 3.04±0.98 | 3.13±0.90 | 2.617a | 0.007 |
ALT〔M(P25,P75),U/L〕 | 17(12,25) | 23(15,37) | -11.595 | <0.001 |
血尿酸〔M(P25,P75),μmol/L〕 | 291(241,348) | 337(276,397) | -12.760 | <0.001 |
项目 | 赋值 | 项目 | 赋值 |
---|---|---|---|
年龄 | 实测值 | 2 hPG | 实测值 |
性别 | 男=0,女=1 | Scr | 实测值 |
糖尿病病程 | 实测值 | HbA1c | 实测值 |
吸烟史 | 不吸烟=0,吸烟=1 | 空腹C肽 | 实测值 |
饮酒史 | 不饮酒=0,饮酒=1 | 餐后2 hC肽 | 实测值 |
高血压病史 | 无=0,有=1 | TG | 实测值 |
降压药用药史 | 无=0,有=1 | TC | 实测值 |
收缩压 | 实测值 | HDL | 实测值 |
舒张压 | 实测值 | LDL | 实测值 |
腰臀比 | 实测值 | ALT | 实测值 |
FPG | 实测值 | 血尿酸 | 实测值 |
Table 2 Assignment for variables possibly,independently associated with the correlation between obesity and albuminuria in T2DM patients assessed using binary Logistic regression analysis
项目 | 赋值 | 项目 | 赋值 |
---|---|---|---|
年龄 | 实测值 | 2 hPG | 实测值 |
性别 | 男=0,女=1 | Scr | 实测值 |
糖尿病病程 | 实测值 | HbA1c | 实测值 |
吸烟史 | 不吸烟=0,吸烟=1 | 空腹C肽 | 实测值 |
饮酒史 | 不饮酒=0,饮酒=1 | 餐后2 hC肽 | 实测值 |
高血压病史 | 无=0,有=1 | TG | 实测值 |
降压药用药史 | 无=0,有=1 | TC | 实测值 |
收缩压 | 实测值 | HDL | 实测值 |
舒张压 | 实测值 | LDL | 实测值 |
腰臀比 | 实测值 | ALT | 实测值 |
FPG | 实测值 | 血尿酸 | 实测值 |
模型 | B | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
模型1 | 0.550 | 0.086 | 1.733(1.463,2.052) | 40.578 | <0.001 |
模型2 | 0.377 | 0.090 | 1.458(1.222,1.740) | 17.555 | <0.001 |
模型3 | 0.277 | 0.097 | 1.319(1.092,1.594) | 8.238 | 0.004 |
模型4 | 0.236 | 0.114 | 1.266(1.013,1.582) | 4.299 | 0.038 |
Table 3 Binary Logistic regression analysis of the correlation between obesity and albuminuria in T2DM patients
模型 | B | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
模型1 | 0.550 | 0.086 | 1.733(1.463,2.052) | 40.578 | <0.001 |
模型2 | 0.377 | 0.090 | 1.458(1.222,1.740) | 17.555 | <0.001 |
模型3 | 0.277 | 0.097 | 1.319(1.092,1.594) | 8.238 | 0.004 |
模型4 | 0.236 | 0.114 | 1.266(1.013,1.582) | 4.299 | 0.038 |
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