Chinese General Practice ›› 2022, Vol. 25 ›› Issue (02): 243-247.DOI: 10.12114/j.issn.1007-9572.2021.01.311

Special Issue: 睡眠研究最新文章合集 睡眠问题专题研究

• Latest Developments • Previous Articles     Next Articles

Recent Advances in the Pathogenesis of Glucolipid Metabolism Disorder in Obstructive Sleep Apnea-hypopnea Syndrome

  

  1. Yan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051China

    *Corresponding authorYANG LiChief physicianE-mail13330466619@189.cn

  • Received:2021-08-06 Revised:2021-10-09 Published:2022-01-15 Online:2021-12-29

阻塞性睡眠呼吸暂停低通气综合征与糖脂代谢紊乱的机制研究进展

  

  1. 650051 云南省昆明市,昆明医科大学附属延安医院
  • 通讯作者: 杨莉
  • 基金资助:
    云南省重大科技专项计划项目(2017ZF027);云南省科技厅-昆医联合专项重点项目(2017FE468(-008));云南省重大科技专项计划项目(2017ZF024-12)

Abstract:

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a disease marked by apnea, hypopnea, decreased oxygen saturation, and disordered sleep structure, which is a major risk for cardiovascular disease. Recent studies have found that OSAHS patients have an increased risk of hypertension, coronary atherosclerotic heart disease, insulin resistance, type 2 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, etc. And these patients have a high prevalence of obvious glucolipid metabolism disorder (GMD) , which plays an important role in cardiovascular morbidity and mortality in OSAHS. We reviewed the latest advances in the association of GMD and OSAHS, and the potential pathogenesis of OSAHS-induced GMD and insulin resistance, aiming at providing new ideas for clinical treatment of GMD in OSAHS.

Key words: Sleep apnea, obstructive, OSAHS, Glucose metabolism, Lipid metabolism, Insulin resistance, Cardiovascular diseases, Review

摘要:

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是以呼吸暂停、低通气、血氧饱和度下降及睡眠结构紊乱为特征的一种疾病,是心血管疾病的严重危险因素。近年来研究发现,OSAHS患者合并高血压、冠状动脉粥样硬化性心脏病、胰岛素抵抗、2型糖尿病、代谢综合征、非酒精性脂肪肝等疾病的发病率增加。诸多研究显示,OSAHS患者常存在明显的糖脂代谢紊乱,并在心血管疾病的发病率、死亡率中扮演着重要角色。因此,本文从OSAHS与糖脂代谢的关系入手,从病因学层面,就OSAHS引起糖脂代谢紊乱及胰岛素抵抗的机制作一综述,以期为临床治疗提供新的思路。

关键词: 睡眠呼吸暂停, 阻塞性, 阻塞性睡眠呼吸暂停低通气综合征, 糖代谢, 脂代谢, 胰岛素抵抗, 心血管疾病, 综述

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