Abstract: Background  There is a close relationship between binge eating disorder（BED） and type 2 diabetes mellitus（T2DM）．At present，there is a great difference in the research results of BED among patients with T2DM.Moreover，the mechanism of BED is mainly discussed from the perspectives of mental state and psychological model，and there is no analysis of clinical biochemical indicators.Objective  To study the incidence of BED in T2DM patients，T2DM patients with an increased risk of BED，and its influence on blood sugar，blood lipid，comorbidities and complications.Methods  234 T2DM patients were selected from Department of Endocrinology，Lu'an Second People's Hospital from January to June 2018.Symptoms data were collected by consultations.According to the DSM-Ⅴ diagnostic criteria for BED，they were divided into BED and non-BED groups.Comparative analyses of two groups' demographic data（sex，age，and BMI） and biochemical data 〔glycated hemoglobin（HbA1c），fasting blood glucose（FPG），serum C-peptide（C-P），total cholesterol（TC），triglyceride（TG），high-density lipoprotein cholesterol（HDL-C），and low-density lipoprotein（LDL-C）〕 and incidence of 7 chronic complications /comorbidities were performed.Results  The incidence of BED was 9.0%（21/234）．Compared with non-BED group，BED group had lower percentage of males，greater mean age，and higher BMI，HbA1c and FPG levels（P<0.05），but had similar mean T2DM duration，and mean serum C-P，TC，TG，HDL-C and LDL-C levels（P>0.05）．Moreover，two groups showed insignificant difference in the incidence of chronic complications and comorbidities（peripheral neuropathy，peripheral vascular disease，diabetic nephropathy，diabetic retinopathy，diabetic foot，coronary heart disease and cerebral infarction）（P>0.05）．Conclusion  The incidence of BED in patients with T2DM is high.In particular，those who are female or obese are more susceptible to BED.BED can have adverse effects on blood sugar control in patients with T2DM，but has little effect on blood lipid level，complications and comorbidities.

Key words: Diabetes mellitus, type 2；Binge-eating disorder；Glucose-control

摘要： 背景  暴食症（BED）与2型糖尿病（T2DM）有着紧密的联系，目前国内外针对T2DM伴BED的研究结果差异较大，且多是从精神状态和心理模型角度探讨其机制，缺乏临床上生化指标的数据分析。目的  研究T2DM患者中BED的发生率、易发人群及其对血糖、血脂、合并症及并发症的影响。方法  选取六安市第二人民医院内分泌科2018年1—6月收治住院的234例T2DM患者为研究对象。采用问诊的方式进行数据采集，依据美国精神障碍诊断统计手册第5版（DSM-Ⅴ）对BED的评判标准分为非BED组（NBED组）和BED组，比较两组性别、年龄、BMI、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、血浆C肽（C-P）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等指标及7种慢性并发症/合并症发生情况。结果  T2DM伴BED者占比为9.0%（21/234）。BED组男性占比、年龄低于NBED组，BMI、HbA1c、FPG水平高于NBED组，差异有统计学意义（P<0.05）；两组病程比较，差异无统计学意义（P>0.05）。两组C-P、TC、TG、HDL-C、LDL-C水平比较，差异无统计学意义（P>0.05）。两组慢性并发症及合并症（周围神经病变、周围血管病变、糖尿病肾病、糖尿病视网膜病变、糖尿病足、冠心病及脑梗死）发生率比较，差异无统计学意义（P>0.05）。结论  T2DM伴BED者占比较高，女性、肥胖者为易发人群，BED可对T2DM患者的血糖控制产生不利影响，而对血脂水平及合并症、并发症影响不大。

关键词: 糖尿病, 2型；暴食症；血糖控制