关键词: 高血压, 高同种半胱氨酸血症, 依那普利, 叶酸, 血栓前状态

Abstract: Objective　To investigate the impact of enalapril maleate folic acid tablets on prethrombotic state in patients with H-type hypertension.Methods　From June 2014 to September 2015,126 level-one hypertension patients who received treatment in the First Affiliated Hospital of Nanchang University were selected.According to the serum homocysteine（Hcy） levels,the included subjects were divided into simple hypertension group（Hcy<10 μmol/L,n=35） and H-type hypertension group（Hcy≥10 μmol/L,n=91）;H-type hypertension patients were divided into control group（n=46） and experiment group（n=45） by random number table method.Patients in simple hypertension group and control group were treated with enalapril maleate tablets orally,patients in experiment group were treated with enalapril maleate folic acid tablets orally,and both of them took continuously for six months.Results　The platelet a granule membrane glycoprotein（CD62p）,platelet lysosome membrane protein（CD63）,von willebrand factor（vWF）,fibrinogen（Fg）,thromboxane B2（TXB2）,plasminogen activator inhibitor-1（PAI-1） of patients in H-type hypertension group were significantly higher than those in simple hypertension group,and its tissue-type plasminogen activator（t-PA） was significantly lower（P<0.05）.The comparison of CD62p,CD63,vWF,Fg,TXB2,t-PA and PAI-1 between patients in control group and experiment group before treatment was not significantly different（P>0.05）;CD62p,CD63,vWF,Fg,TXB2,and PAI-1 of patients after treatment in experiment group were significantly lower than those in control group,while t-PA was significantly higher（P<0.05）.After treatment,CD62p,CD63,vWF,Fg,TXB2,and PAI-1 of patients in experiment group were significantly lower than those before treatment,while t-PA was significantly higher（P<0.05）;while CD62p,CD63,vWF,Fg,TXB2,t-PA,and PAI-1 of patients in control group compared with those of patients before treatment were not significantly different（P>0.05）.Conclusion　H-type hypertension patients have presented even more severe prothrombotic state,and enalapril maleate folic acid tablets can effectively reduce the blood pressure of H-type hypertension patients and improve their prethrombotic state at the same time,which helps prevent the occurrence of cardiovascular and cerebrovascular events.

Key words: Hypertension, Hyperhomocysteinemia, Enalapril, Folic acid, Prethrombotic state