There is an induced or concurrent relationship between cardiovascular disease and psychological illness, which occurred and developed into Psycho-Cardiology. It is necessary to assist the treatment of cardiovascular disease from the perspective of psychology, the resulting is the Psycho-Cardiology. This article briefly summarized the research status at home and abroad about Psycho-Cardiology. Firstly, analyzing the internal mechanism and external influencing factors to establish theoretical mechanism, and determine the high incidence risk index of the Psycho-Cardiology disease. Baseline information, including age, gender, BMI, diet, smoking, alcohol consumption, physical exercise, social status, family history, comorbidity including hypertension. Hematological indicators, including ion concentration, blood cell, inflammatory factor, hormone. Biochemical indicators, including myocardial enzyme spectrum, blood glucose, blood lipid, uric acid, cysteine. Structural and functional indicators, including resting heart rate (RHR) , heart rate variability (HRV) , left ventricular ejection fraction (LVEF) , left ventricular end diastolic diameter (LVDd) . These factors have a relevance between cardiovascular disease and psychological illness. Then, exploring two diagnosis models of this disease, including a traditional model of multi-axis, multi-grade, and multi-scale diagnosis methods, and a intelligent diagnosis section system based on the risk indexes. From the clinical practice, aiming to help clinicians achieve early psychological screening and accurate diagnosis of Psycho-Cardiology disease patients, and implement effective intervention measures.