不同糖代谢水平人群血尿酸水平与体脂分布的相关性分析

doi:10.12114/j.issn.1007-9572.2021.00.507

摘要/Abstract

摘要： 背景　作为代谢性疾病的重要表现之一，高尿酸血症是2型糖尿病、肥胖症等疾病的重要危险因素，但是目前关于不同糖代谢水平人群血尿酸水平与体脂分布的相关性研究甚少。目的　探究不同糖代谢人群血尿酸水平与体脂分布的相关性。方法　2015年选取上海市泥城镇云松社区常住居民571例为研究对象。根据世界卫生组织（WHO）1998年制定的糖尿病诊断标准，将受试者分为糖耐量正常组（NGT组）、糖耐量异常组（IGR组）、2型糖尿病组（T2DM组）。根据2010年《无症状高尿酸血症合并心血管疾病诊治建议中国专家共识》诊断高尿酸血症。比较NGT组、IGR组、T2DM组不同血尿酸水平者一般资料、生化指标和体脂指标，并分析不同糖代谢水平者血尿酸水平与各体脂指标的相关性。结果　NGT组196例，其中高尿酸血症24例（12.2%）；IGR组170例，其中高尿酸血症27例（21.8%）；T2DM组205例，其中高尿酸血症30例（14.6%）。三组高尿酸血症发生率比较，差异无统计学意义（χ2=1.042，P=0.594）。NGT组无高尿酸血症者年龄小于高尿酸血症者，体质指数（BMI）、三酰甘油（TG）、空腹胰岛素、躯干脂肪百分比/腿部脂肪百分比（TF%/LF%）、躯干脂肪质量/四肢脂肪质量（TFM/LFM）、腹臀比（A/G）低于高尿酸血症者，高密度脂蛋白胆固醇（HDL-C）高于高尿酸血症者（P<0.05）。IGR组无高尿酸血症者男性所占比例、腰臀比、TF%/LF%、TFM/LFM、A/G低于高尿酸血症者，HDL-C、上肢脂肪百分比（ULF%）、下肢脂肪百分比（LLF%）高于高尿酸血症者（P<0.05）。T2DM组无高尿酸血症者年龄小低于高尿酸血症者，女性所占比例、BMI、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、全身脂肪百分比（BF%）、躯干脂肪百分比（TF%）、ULF%、LLF%低于高尿酸血症者（P<0.05）。Pearson相关分析结果显示，不同糖代谢水平者血尿酸水平与TF%/LF%、TFM/LFM、A/G均呈正相关（P<0.05）；NGT组、IGR组血尿酸水平与腰臀比呈正相关，与BF%、TF%、ULF%、LLF%呈负相关（P<0.05）。结论　不同糖代谢水平人群血尿酸水平、体脂分布均存在差异，且血尿酸水平与体脂分布情况密切相关。

关键词: 葡萄糖代谢障碍；糖尿病；尿酸；体脂分布；因素分析, 统计学

Abstract: Background　Hyperuricemia is an important manifestation of metabolic diseases，and a significant risk factor for type 2 diabetes and obesity and so on.However，there are few studies on the correlation between serum uric acid level and body fat distribution in individuals by glucose metabolism.Objective　To investigate the relationship between serum uric acid level and body fat distribution in adult population by glucose metabolism.Methods　A total of 571 adult permanent residents were recruited from Shanghai Nicheng Town Yunsong Community in 2015.According to the 1998 WHO diagnostic criteria for diabetes，they were divided into groups of normal glucose tolerance （NGT），impaired glucose regulation （IGR），and type 2 diabetes mellitus（T2DM）.Hyperuricemia was diagnosed according to the 2010 Chinese Expert Consensus Recommendations for the Diagnosis and Treatment of Asymptomatic Hyperuricemia with Cardiovascular Diseases.Intragroup comparisons of the general demographic information，biochemical and body fat indices by hyperuricemia prevalence were performed to examine the potential association of serum uric acid level and body fat indices.Results　The hypeluricemia prevalence was 12.2%（24/196），21.8%（27/170），and 14.6%（30/205），respectively，in NGT，IGR and T2DM groups，showing no significant statistical difference（χ2=1.042，P=0.594）.In NGT group，those with hyperuricemia had greater mean age，and greater average levels of BMI，triacylglycerol，fasting insulin，trunk fat percentage to leg fat percentage （TFP/LFP） ratio，trunk fat mass to limb fat mass（TFM/LFM） ratio，abdominal fat percentage to hip fat percentage （AFP/HFP） ratio，and lower average level of high-density lipoprotein cholesterol （HDL-C） than those without（P<0.05）.In IGR group，those with hyperuricemia had higher men ratio，waist-to-hip ratio，TFP/LFP ratio，TFM/LFM ratio，and AFP/HFP ratio，and lower average levels of HDL-C，upper and lower limb fat percentages than those without （P<0.05）.In T2DM group，Those with hyperuricemia had greater average age and women ratio，and higher average levels of BMI，total cholesterol，low-density lipoprotein cholesterol，body fat percentage，trunk fat percentage，upper limb fat percentage，and lower limb fat percentage than those without （P<0.05）.Pearson correlation analysis results showed that the level of serum uric acid was positively correlated with TFP/LFP ratio，TFM/LFM ratio and AFP/HFP ratio （P<0.05）in each group；serum uric acid level was positively correlated with waist-to-hip ratio，but negatively correlated with body fat percentage，trunk fat percentage，upper limb fat percentage，and lower limb fat percentage in NGT and IGR groups（P<0.05）.Conclusion　The serum uric acid level and body fat distribution differed significantly among individuals by glucose metabolism，and the serum uric acid level may be closely related to body fat distribution.

Key words: Glucose metabolism disorders；Diabetes mellitus；Uric acid；Body fat distribution；Factor analysis, statistical

肖元元,姜智峰,蒋伏松,等. 不同糖代谢水平人群血尿酸水平与体脂分布的相关性分析[J]. 中国全科医学, 2021, 24(21): 2675-2679. DOI: 10.12114/j.issn.1007-9572.2021.00.507.
XIAO Yuanyuan,JIANG Zhifeng,JIANG Fusong, et al. Correlation of Serum Uric Acid Level and Body Fat Distribution in Individuals by Glucose Metabolism　[J]. Chinese General Practice, 2021, 24(21): 2675-2679. DOI: 10.12114/j.issn.1007-9572.2021.00.507.

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