关键词: 黏膜皮肤淋巴结综合征, 临床表现, 冠状动脉损害, 发热

Abstract: Objective　To summarize the clinical features and laboratory results of incomplete Kawasaki disease （IKD） in children，providing evidence for early clinical recognition，diagnosis and prognosis improvement of this disease.Methods　We enrolled 94 children with IKD who received inpatient treatment in Department of Pediatrics，Wuhan No.1 Hospital from July 2016 to July 2018 in accordance with the inclusion criteria of this study，including 53 with typical KD（typical KD group），and 41 with atypical KD（IKD group）．Through the His system of the hospital，we collected and retrospectively analyzed their clinical data，including sex，age，clinical manifestations（fever interval before diagnosis，bulbar conjunctival congestion，chapped lips，strawberry tongue，fingernail and toenail shedding，perianal desquamation，rash，cervical lymphadenopathy，redness and swelling of the BCG vaccination scar），laboratory results during the acute stage of KD 〔erythrocyte sedimentation rate，C-reactive protein （CRP），white blood cell count，hemoglobin，neutrophil percentage （N%），platelet count，serum albumin，A/G ratio，AST，ALT，CK-MB 〕，and results of etiology detection，echocardiography and electrocardiogram（ECG）．Results　Two groups had no significant differences in sex ratio （χ2 =0.106，P>0.05） and age distribution（Z=-1.760，P>0.05）．Compared with typical KD group，IKD group demonstrated longer average fever interval before diagnosis，lower rates of chapped lips，fingernail and toenail shedding，perianal desquamation，rash，and cervical lymphadenopathy，higher rate of redness and swelling of the BCG vaccination scar，and lower average levels of CRP and N% at the acute stage of KD（P<0.05）．Among the typical KD group，there were 19 cases （35.9%） with clear etiologies，including 6 cases of viral infection，5 cases of bacterial infection，5 cases of Mycoplasma infection and 3 cases of mixed bacterial and viral infection，and in IKD group，there were 22 cases （53.7%） with clear etiologies，including 9 cases of Mycoplasma infection，6 cases of bacterial infection，5 cases of viral infection，and 2 cases of mixed bacterial and viral infection，indicating there was no significant difference in the incidence of pathogenic infection between the groups （χ2 = 2.981，P>0.05）．The incidence of coronary artery dilatation in IKD group was higher than that of typical KD group （P<0.05）．Conclusion　IKD was associated with longer fever interval，higher possibilities of having redness and swelling of the BCG vaccination scar，and coronary artery dilatation，but not associated with noticeable clinical manifestations.If children are found with the above-mentioned symptoms，IKD should be suspected，and inflammatory marker test should be performed as soon as possible，in order to obtain a definite diagnosis early.

Key words: Mucocutaneous lymph node syndrome, Clinical manifestations, Coronary damage, Fever