关键词: 肠道菌群, 肠杆菌, 肠道细菌, 颈椎病, 相关性, 免疫炎症, 肠脑轴

Abstract: Cervical spondylosis（CS） has been regarded as a degenerative disease of the spine caused by external strain.Most of the studies focus on its structural changes，but few on its immune mechanism.The intestinal flora（IF） has been shown to be widely involved in the immune regulation of various tissues of the human body，and it is also possible to influence the occurrence and development of CS through immunoinflammatory pathways.Through literature review and analysis of the influence of IF imbalance on bone，blood vessels，nerves and muscles，it was suggested that IF imbalance may act on the main tissues of the neck by the gut-brain axis as main stem，causing neck tissue lesions.The chronic low-level immune inflammation caused by IF imbalance，which is the fundamental basis for the formation of CS，can cause damage to the neck tissues of bones，blood vessels，nerves and muscles，while stress strain is only a supplementary factor and the degeneration of neck tissues is only a process or result in this disease.CS is not only a manifestation of the cervical spine aging and disuse，but also more should be regarded as a neck injury caused by intestinal immune disorders.In the clinical treatment of CS，it should pay attention to reasonable diet for protecting intestinal function and maintaining the existing attributes of IF.

Key words: Intestinal flora, Enterobacteria, Enteric bacteria, Cervical spondylosis, Correlation, Immune inflammation, Gut-brain axis