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中国全科医学 ›› 2018, Vol. 21 ›› Issue (15): 1801-1804.DOI: 10.3969/j.issn.1007-9572.2017.00.237

所属专题： 肺癌最新文章合辑

• 专题研究 • 上一篇    下一篇

血清雌激素水平和miR-365表达水平在非小细胞肺癌患者中的变化及其相关性研究

李树坡，李鹏*，余捍东，赵晶   

  1. 443001湖北省宜昌市，三峡大学附属仁和医院胸外科
    *通信作者：李鹏，主治医师；E-mail：28477239@qq.com
  • 出版日期:2018-05-20 发布日期:2018-05-20

Change and Correlation of Serum Estrogen and miR-365 Expression Levels in Non-small Cell Lung Cancer Patients　

  1. Department of Thoracic Surgery，Affiliated Renhe Hospital of China Three Gorges University，Yichang 443001，China
    *Corresponding author：LI Peng，Attending physician；E-mail：28477239@qq.com
  • Published:2018-05-20 Online:2018-05-20

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摘要： 目的　探讨血清雌激素水平和miR-365表达水平在非小细胞肺癌（NSCLC）患者中的变化及其相关性，以期为NSCLC的早期诊断和治疗提供新的思路。方法　选取2015年3月—2016年4月在三峡大学附属仁和医院接受原发性NSCLC手术切除的57例患者作为NSCLC组，选取同期本院体检中心体检健康者50例作为对照组。收集研究对象的一般资料，检测血清雌激素水平、miR-365表达水平，分析血清雌激素水平与miR-365表达水平的相关性。结果　NSCLC组血清雌激素水平高于对照组（t=2.73，P=0.01），miR-365表达水平低于对照组（t=2.65，P=0.02）。在NSCLC组中鳞状细胞癌、腺鳞癌患者miR-365表达水平高于腺癌（P<0.05），低分化患者miR-365表达水平低于高分化（P<0.05），TNM分期为Ⅰ~Ⅱ期患者miR-365表达水平高于Ⅲ~Ⅳ期（P<0.05），有淋巴结转移患者 miR-365表达水平低于无淋巴结转移（P<0.05）。NSCLC组血清雌激素水平与miR-365表达水平呈负相关（r=-0.574，P=0.02）。结论　NSCLC患者血清雌激素水平升高，miR-365表达水平下降，且两者具有相关性，可作为NSCLC患者早期诊断和发展转归的重要参考指标。

关键词: 癌, 非小细胞肺, 受体, 雌激素, 微RNAs, 早期诊断

Abstract: Objective　To investigate the change and correlation of serum estrogen and miR-365 levels in non-small cell lung cancer（NSCLC） patients，and to provide new insight for the early diagnosis and treatment monitoring of this disorder.Methods　Fifty-seven patients who underwent resection of primary NSCLC in the Affiliated Renhe Hospital of China Three Gorges University from March 2015 to April 2016 were selected as the NSCLC group；50 healthy volunteers who received physical examinations in the hospital during the same period were selected as the control group.General information of the participants was collected，and the expression levels of serum estrogen and miR-365 were determined.The correlation between serum estrogen levels and miR-365 expression levels were then analyzed.Results　The serum estrogen level in the NSCLC group was significantly higher than that in the control group（t=2.73，P=0.01），while miR-365 expression level in the NSCLC group was significantly lower than that in the control group（t=2.65，P=0.02）．In the NSCLC group，patients with squamous cell carcinoma and adenosquamous carcinoma had higher expression of miR-365 than patients with adenocarcinoma（P<0.05），patients with poor differentiation was associated with a lower expression level of miR-365 than patients with high differentiation（P<0.05）．In the NSCLC group，for the TNM stage，patients in stages Ⅰ-Ⅱ had a higher expression level of miR-365 than patients in stages Ⅲ-Ⅳ（P<0.05）．In the NSCLC group，the expression level of miR-365 in patients with lymph node metastasis was lower than those without lymph node metastasis（P<0.05）．Moreover，in the NSCLC group，the serum estrogen level showed a negative correlation with the miR-365 expression level（r=-0.574，P=0.02）．Conclusion　Serum estrogen levels increased and miR-365 expression levels decreased in patients with NSCLC.The serum estrogen level was negatively correlated with the miR-365 expression level.Both serum estrogen and miR-365 levels were important biomarkers for the early diagnoses of NSCLC and the prediction of patient outcomes.

Key words: Carcinoma, non-small-cell lung cancer；Receptors, estrogen；MicroRNAs；Early diagnosis

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