关键词: 高血压, 肺性, 苓桂术甘汤, 治疗结果

Abstract: Objective　To investigate the clinical effects of Lingguizhugan decoction in the treatment of hypoxic pulmonary hypertension（HPH）.Methods　96 HPH patients who received treatment in Lanzhou University Second Hospital from May 2013 to August 2015 were selected and divided into control group（n=44） and experimental group（n=52） by using random number table method.The control group was treated with conventional therapy,based on which the experimental group took Lingguizhugan decoction.The average time of therapy of patients in two groups was（12±2） d.Serum N-terminal pro brain natriuretic peptide（NT-proBNP） level,hearts and lungs function indices,blood gas analysis,TCM symptom scores,and efficacy of TCM syndrome and occurrence of adverse reactions among patients in two groups before and after treatment were compared.Results　Serum NT-proBNP levels of patients in two groups before treatment were not significantly different（P>0.05）;after treatment,serum NT-proBNP level of patients in experimental group was significantly lower than that in control group（P<0.05）;serum NT-proBNP levels of patients in two groups after treatment were significantly lower than those before treatment（P<0.05）.There was no significant difference in cardiac output（CO）,left ventricular ejection fraction（LVEF） and pulmonary artery pressure of patients in two groups before treatment（P>0.05）;after treatment,CO and LVEF of patients in experimental group were significantly higher than those in control group,while pulmonary artery pressure in experimental group was lower than that in control group（P<0.05）;both CO and LVEF of patients in two groups after treatment were significantly lower than those before treatment,while pulmonary artery pressure after treatment was lower than that before treatment（P<0.05）.pH,partial pressure of blood oxygen（PaO2） and arterial partial pressure of carbon dioxide（PaCO2） of patients in two groups before treatment were not significantly different（P>0.05）.pH of patients in two groups was not significantly different（P>0.05）;PaO2 of patients in experimental group was significantly higher than that in control group,while PaCO2 was lower than that in control group（P<0.05）.pH of patients in two groups after treatment and before treatment was not significantly different（P>0.05）;PaO2 in two groups was significantly higher than that before treatment,PaCO2 was significantly lower than that before treatment（P<0.05）.There was no significant difference in TCM symptom scores of patients in two groups before treatment（P>0.05）;after treatment,TCM symptom scores of patients in experiment group were significantly lower than those in control group（P<0.05）;TCM symptom scores of patients in two groups after treatment were significantly lower than those before treatment（P<0.05）.Efficacy of TCM syndrome of patients in experiment group was better than that in control group（P<0.05）.Patients in two groups had no obvious adverse reaction.Conclusion　Conclusion Lingguizhugan decoction has precise clinical effects on the treatment of HPH,and can remit patients’ hypoxic condition.It benefits prognosis of patients.

Key words: Hypertension,pulmonary, Lingguizhugan decoction, Treatment outcome