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中国全科医学

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慢性阻塞性肺疾病合并高血压患者肺功能与血压变异性的相关研究

宋路, 王丽晔, 修春霞, 冯宝静, 冯丽萍, 高艳松, 李梦, 代妍   

  1. 开滦总医院呼吸与危重症医学科二病区, 河北 063000 中国
    开滦总医院呼吸与危重症医学科一病区, 河北 063000 中国
  • 收稿日期:2024-09-23 修回日期:2024-11-10 接受日期:2024-11-19
  • 通讯作者: 代妍

The Correlation Study of Pulmonary Function and Blood Pressure Variability in Patients with Chronic Obstructive Pulmonary Disease and Hypertension

song lu, wang ye li, xiu xia chun, feng jing bao, feng ping li, gao song yan, li meng, dai yan   

  1. , 063000, China
  • Received:2024-09-23 Revised:2024-11-10 Accepted:2024-11-19
  • Contact: dai, yan
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摘要： 【摘要】　背景　慢性阻塞性肺疾病（COPD）与心血管疾病关系密切，但是两者之间相互影响的机制仍不明确。高血压作为COPD最常见的合并症，同时也是心脑血管疾病的独立危险因素。目前研究认为血压变异性也是心血管疾病的危险因素，血压变异性比单次血压值更能体现患者血压波动的情况，那么血压变异性是否为COPD与心血管疾病之间的桥梁？目前国内无相关研究。目的　探讨COPD合并高血压患者肺功能与血压变异性的相关性。方法　纳入2020年09月至2023年09月于开滦总医院呼吸与危重症医学科门诊就诊的COPD合并高血压病患者341例。采用多因素线性回归分析肺功能指标（用力肺活量占预计值百分比：FVC%pred，第1秒用力呼气容积占预计值百分比：FEV1%pred，第1秒用力呼气容积与用力肺活量比值：FEV1/FVC）与血压变异性（收缩压标准差：SDSBP，舒张压标准差：SDDBP）的相关性。结果　（1）在341例患者中，年龄平均为63.74±3.01岁。其中，男性244例（71.55%），女性97例（28.45%）。（2）FEV1%pred与血压变异性（SDSBP、SDDBP）均呈负相关；rs值分别为-0.149、-0.114。（3）FEV1%pred与SDSBP、SDDBP均呈负线性相关，B值（95%CI）分别为-0.566（-1.078~-0.054）、-0.427（-0.761~-0.093）；FVC%pred和FEV1/FVC与SDSBP、SDDBP均无相关性。结论　FEV1%pred与SDSBP、SDDBP呈负线性相关。

关键词: 慢性阻塞性肺疾病, 高血压, 肺功能, 血压变异性, 线性回归分析, 唐山市

Abstract: 【Abstract】　Background　Chronic obstructive pulmonary disease（COPD）is closely related to cardiovascular disease， but the mechanism of their interaction is still unclear. Hypertension is the most common comorbidity of COPD，and it is also an independent risk factor for cardiovascular diseases. Current studies believe that blood pressure variability is also a risk factor for cardiovascular disease，and blood pressure variability can better reflect the patient's blood pressure fluctuation than a single blood pressure value，so is blood pressure variability a bridge between COPD and cardiovascular disease? At present，there are no relevant studies in China. Objective　To investigate the correlation study of pulmonary function and blood pressure variability in patients with chronic obstructive pulmonary disease and hypertension. Methods　341 COPD patients with hypertension who visited the Respiratory and Critical Care Medicine Outpatient Department of Kailuan General Hospital from September 2020 to September 2023. Multiple factor linear regression was used to analyze the correlation between lung function indicators（percentage of forced vital capacity to predicted value： FVC%pred； percentage of forced expiratory volume to predicted value in the first second：FEV1%pred； the ratio of forced expiratory volume in one second to forced vital capacity：FEV1/FVC）and blood pressure variability （standard deviation of systolic blood pressure：SDSBP，standard deviation of diastolic blood pressure：SDDBP）. Results　（1）Among 341 patients，the average age was 63.74±3.01 years. Among them，there were 244 males（71.55%）and 97 females（28.45%).（2）FEV1%pred is negatively correlated with blood pressure variability（SDSBP，SDDBP)；The rs values are -0.149 and -0.114，respectively.（3）FEV1%pred is negatively linearly correlated with SDSBP and SDDBP，with B values（95% CI）of -0.566（-1.078~-0.054）and -0.427（-0.761~-0.093），respectively；FVC%pred and FEV1/FVC were not correlated with SDSBP and SDDBP. Conclusion　FEV1%pred is negatively linearly correlated with SDSBP and SDDBP.

Key words: Chronic obstructive pulmonary disease, Hypertension, Pulmonary function, Blood pressure variability, Linear regression analysis, Tangshan city

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