关键词: 支气管哮喘, 前期, 中医外治法, 中药穴位贴敷, 随机对照试验

Abstract: Purpose　To assess the efficacy and safety of acupoint application of Tianjiu Powder for the treatment of preliminary asthma，forming a traditional Chinese medicine（TCM） external therapy plan of preliminary asthma. Methods　 123 preliminary asthma patients were randomly divided into 62 in the treatment group and 61 in the control group with 24 weeks for treating and 24 weeks for following after the end of treatment. Acupoint application of Tianjiu Powder was given to the treatment group，placebo acupoint application was given to the control group. The negative rate and positive rate of bronchial provocation /dilation test，TCM syndrome score，the SF-36，lung function FEV1 and small airway function，eosinophil（EOS%） and total serum immunoglobulin E（IgE） were compared between the treatment group and the control group before and after treatment. Adverse reactions were recorded during treatment. Results　The negative rate of bronchial provocation /dilation test in the treatment group（66.1%，64.5%，58.1%） was higher than that in the control group（47.5%，44.3%，36.1%）（P < 0.05） at week 12，week 24 and week 48. The difference before and after treatment of lung function PEF in the treatment group was higher than that in the control group（P < 0.05） at week 12 and week 24 . PF and RP score which belonged to SF-36 in the treatment group were higher than them in the control group（P < 0.05） at week 48. The positive rate and doubtful positive rate of bronchial provocation /dilation test and TCM syndrome score in the treatment group were lower than them in the control group at week 12，week 24 and week 48，however，there was no significant difference between the two groups（P ＞ 0.05）. There was no significant difference of EOS% and IgE between the two groups at pre-treatment and week 24. There was no significant difference of the incidence of adverse reactions between the two groups（P ＞ 0.05）. Conclusions　Acupoint application of Tianjiu Powder can enhance the negative rate of bronchial provocation /dilation test，improve PEF and the quality of life in preliminary asthma patients. It suggested that preliminary asthma could be prevented and controlled，provided a new idea for early prevention and control of asthma.

Key words: Bronchial asthma, Preliminary, External therapy of Chinese medicine, Acupoint application of Chinese medicine, Randomised controlled trial