小肠电刺激治疗2型糖尿病的机制研究进展

doi:10.12114/j.issn.1007-9572.2021.02.004

摘要/Abstract

摘要： 糖尿病的治疗方案较多，但许多原因可导致部分糖尿病患者血糖控制不佳。近年来，小肠电刺激（IES）作为一种新兴的糖尿病治疗方法引起了国内外学者的广泛关注。本文总结了IES治疗2型糖尿病（T2DM）的相关研究，发现IES可以降低空腹血糖及餐后血糖，改善胰岛素抵抗，证明IES能有效治疗T2DM。同时对IES控制血糖的机制进行了探讨，发现IES可以延缓胃排空、加速肠道转运、影响调节血糖的胃肠激素水平、调节自主神经功能等，可能为今后的研究提供新思路。

关键词: 小肠电刺激；电刺激疗法；糖尿病, 2型；血糖；胃肠动力；胃肠激素类；自主神经系统

Abstract: Although there are many therapies for diabetes，poor glycemic control can occur in some diabetes patients due to various reasons. Intestinal electrical stimulation （IES），a new treatment for diabetes，has attracted wide attention of scholars. We reviewed recent studies about IES for type 2 diabetes，and concluded that IES could reduce fasting and postprandial plasma glucose levels and insulin resistance，which has proved its therapeutic value. Furthermore，we found that the glycemic control mechanism of IES may be related to delaying gastric emptying，accelerating intestinal transit，affecting gastrointestinal hormones involved in plasma glucose regulation，and regulating autonomic nervous function. It is hoped that this study could provide new ideas for future research.

Key words: Intestinal electrical stimulation；Electric stimulation therapy；Diabetes mellitus, type 2；Blood glucose；Gastrointestinal motility；Gastrointestinal hormones；Autonomic nervous system

孟乔,谭畅,姚树坤. 小肠电刺激治疗2型糖尿病的机制研究进展[J]. 中国全科医学, 2021, 24(33): 4276-4280. DOI: 10.12114/j.issn.1007-9572.2021.02.004.
MENG Qiao,TAN Chang,YAO Shukun. Advances in the Mechanism of Intestinal Electrical Stimulation in the Treatment of Patients with Type 2 Diabetes　[J]. Chinese General Practice, 2021, 24(33): 4276-4280. DOI: 10.12114/j.issn.1007-9572.2021.02.004.

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