Lifestyle interventions can effectively lower blood glucose levels, promote weight control, improve quality of life, and reduce cardiovascular risk, and constitute a fundamental strategy for the prevention and management of diabetes and other chronic non-communicable diseases. In this context, the American College of Lifestyle Medicine released the Clinical Practice Guideline on Lifestyle Interventions for the Treatment and Remission of Type 2 Diabetes and Prediabetes in Adults, representing the first multidisciplinary clinical practice guideline to position lifestyle intervention as the core therapeutic strategy. Based on available evidence from randomized controlled trials, systematic reviews, and observational studies, the guideline systematically integrates key lifestyle domains, including dietary optimization, promotion of physical activity, sleep management, stress reduction, avoidance of unhealthy substance use, and social support, and establishes a comprehensive management framework encompassing assessment, intervention, follow-up, and dynamic adjustment. The guideline emphasizes patient-centered care and multidisciplinary collaboration, highlights the potential for achieving diabetes remission in selected individuals through intensive lifestyle intervention, and provides principle-based recommendations on medication adjustment and long-term safety monitoring. In addition, practical assessment tools, intervention prescription templates, and follow-up strategies are provided to enhance clinical feasibility. This article interprets the core recommendations of the guideline, focusing on its evidence base, clinical implications, and implementation considerations, with the aim of informing the standardized application of lifestyle interventions in the management of prediabetes and type 2 diabetes in adults.

生活方式干预可有效降低血糖水平、控制体质量、改善生活质量，并降低心血管疾病发生风险，是糖尿病等慢性非传染性疾病防控的重要基础。在此背景下，美国生活方式医学会（ACLM）发布了《成人2型糖尿病及糖尿病前期治疗与缓解的生活方式干预指南》，这是首个以生活方式干预作为核心治疗策略的多学科临床实践指南。该指南基于现有循证医学证据，系统整合饮食结构优化、体力活动促进、睡眠管理、压力干预、避免不良物质使用、社会支持六大关键生活方式要素，构建了覆盖评估、干预、随访与动态调整的整体管理框架。指南强调"以患者为中心"和多学科协作，提出在部分患者中通过强化生活方式干预实现糖尿病缓解的可能性，并对药物调整及长期用药安全性监测提出原则性建议。同时，指南配套提供评估工具、干预处方模板及随访策略，增强了临床实践的可操作性。本文结合指南核心推荐，对其循证基础、临床意义及实施要点进行解读，并立足我国人群特征与糖尿病管理现状提出本土化建议，以期为生活方式干预在糖代谢异常及2型糖尿病管理中的规范化应用提供参考。