Overweight and obesity constitute a significant global public health challenge, impacting individuals across diverse age groups and socioeconomic strata. In 2025, the UK National Institute for Health and Care Excellence (NICE) issued the guideline Overweight and Obesity Management (NG246), which aims to establish an evidence-based therapeutic framework for healthcare practitioners. The NICE guideline underscores the critical role of lifestyle interventions, encompassing behavioral, dietary, and physical activity modalities, and advocates for individualized treatment plans to address the heterogeneous needs of the population. The key updates in this guideline are: (1) Simplifying and optimizing diagnostic tools by recommending differentiated body mass index thresholds for various ethnic groups and strongly endorsing the waist-to-height ratio as the principal assessment tool for central obesity; (2) Elevating the priority of behavioral interventions in weight management, recommending them as the first-line core strategy; (3) Providing more precise, evidence-based recommendations for dietary and physical activity interventions and broadening the implementation settings for weight management. This article aims to interpret the lifestyle intervention component of the NICE guideline and integrate its core principles with the specific context of China, exploring how to effectively apply these updated intervention strategies in the management of overweight and obesity in conjunction with China's domestic guidelines, thereby enhancing the management system and improving the quality of life and health outcomes of affected individuals.

超重和肥胖已成为全球公共卫生问题，影响着不同年龄段和社会背景的人群。2025年，英国国家健康与临床卓越研究所（NICE）发布《超重和肥胖的管理（NG246）》，旨在为医疗、保健人员提供循证治疗框架。该指南强调行为方式、饮食和运动干预等生活方式干预措施的重要性，并提出个性化诊疗方案，以应对不同人群的需求。本次指南的更新亮点在于：（1）简化并优化诊断工具，根据不同族裔人群的差异化BMI界值，强力推荐腰高比（WHtR）作为中心性肥胖的核心评估工具；（2）提升行为干预在体重管理中的优先级，推荐其为一线推荐的核心策略；（3）对饮食和运动干预给出更精准、基于证据的细化推荐，并拓宽体重管理的实施场景。本文旨在通过对NICE指南生活方式干预措施部分的解读，将其核心理念与我国实际情况相结合，探讨如何依据我国指南在体重管理领域有效实施更新的干预策略，完善超重和肥胖管理体系，提高其生活质量和健康水平。