Abstract: Objective　To analyze the difference of dialysis duration between death patients with dabetic nephropathy and death patients with non-diabetic nephropathy who underwent continuous ambulatory peritoneal dialysis （CAPD） during lifetime,and to analyze the correlated factors of dialysis duration among them.Methods　A total of 43 death patients with end stage renal disease （ESRD） who underwent CAPD during lifetime in the First Affiliated Hospital of Guangxi Medical University from 2006 to 2014 were selected as study subjects.According to the primary disease,the patients were divided into diabetic nephropathy group （10 cases） and non-diabetic nephropathy group （33 cases）.Clinical data including sex,age at the beginning of CAPD,dialysis duration,systolic blood pressure,diastolic blood pressure,pulse,height,degree of weight of lower limbs,degree of edema of lower limbs,levels of hemoglobin （Hb）,C-reactive protein （CRP）,serum albumin （Alb）,potassium,calcium,phosphorus,blood urea nitrogen （BUN）,creatinine （Cr）,intact parathyroid hormone （iPTH）,total cholesterol （TC）,three acyl glycerin （TG）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）,fasting blood glucose,ultrafiltration volume,the 4 h dialysate-to-plasma ratio （D/P） of creatinine,estimated glomerular filtration rate （eGFR）,24 h urine volume,total liquid output （24 h ultrafiltration volume +24 h urine volume）,peritoneal urea clearance （peritoneal KT/V）,and total urea clearance （total KT/V） of patients at the beginning of CAPD were analyzed.Results　There was no significant difference in sex,age,systolic blood pressure,diastolic blood pressure,pulse,height,degree of edemaof lower limbs,Hb,CRP,Alb,potassium,calcium,phosphorus,BUN,iPTH,TC,TG,HDL-C,LDL-C,ultrafiltration volume,D/P,eGFR,24 h urine volume,total content,peritoneal KT/V,and total KT/V between non-diabetic nephropathy group and diabetic nephropathy group （P>0.05）.Dialysis duration 〔（39.1±24.4） months vs.（20.7±15.8） months〕and the level of Cr in non-diabetic nephropathy group were higher than those in diabetic nephropathy group （P<0.05）.Weight and fasting blood glucose level in non-diabetic nephropathy group were lower than those in diabetic nephropathy group （P<0.05）.Dialysis duration was not linear correlated with sex,age,systolic blood pressure,diastolic blood pressure,height,weight,degree of edema of lower limbs,Hb,CRP,Alb,potassium,calcium,phosphorus,BUN,Cr,iPTH,TC,TG,LDL-C,fasting blood glucose,ultrafiltration volume,and D/P （P>0.05）.Dialysis duration was negatively correlated with pulse,and positively correlated with HDL-C,eGFR,24 h urine volume,total liquid output,peritoneal KT/V and total KT/V （P<0.05）.Conclusion　The dialysis duration of diabetic nephropathy patients receiving CAPD was shorter than that of non-diabetic nephropathy patients receiving CAPD.Pulse,HDL-C,eGFR,24 h urine volume,total liquid output,peritoneal Kt/V and total KT/V are correlated with dialysis duration.

Key words: Peritoneal dialysis, Diabetes mellitus, Death, Dialysis duration, Correlation analysis

摘要： 目的　探讨持续性非卧床腹膜透析（CAPD）死亡的糖尿病肾病与非糖尿病肾病患者透析龄的差异及其相关因素。方法　选取2006—2014年广西医科大学第一附属医院行CAPD死亡的终末期肾脏病（ESRD）患者43例为研究对象。根据原发病将患者分为糖尿病肾病组（10例）和非糖尿病肾病组（33例）。记录患者临床资料，包括性别、开始CAPD时年龄、透析龄、收缩压、舒张压、脉搏、身高、体质量、双下肢水肿程度、血红蛋白（Hb）、C反应蛋白（CRP）、清蛋白（Alb）、钾、钙、磷、血尿素氮（BUN）、肌酐（Cr）、全段甲状旁腺激素（iPTH）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖水平、超滤量、4 h透析液肌酐与血液肌酐比值（D/P）、残余肾功能〔估算肾小球滤过率（eGFR）〕、24 h尿量、总出水量（24 h超滤量+24 h尿量）、腹膜尿素清除率（KT/V）、总KT/V。结果　非糖尿病肾病组与糖尿病肾病组患者性别、年龄、收缩压、舒张压、脉搏、身高、双下肢水肿程度、Hb、CRP、Alb、钾、钙、磷、BUN、iPTH、TC、TG、HDL-C、LDL-C、超滤量、D/P、eGFR、24 h尿量、总出水量、腹膜KT/V、总KT/V比较，差异无统计学意义（P>0.05）；非糖尿肾病病组患者透析龄〔（39.1±24.4）个月与（20.7±15.8）个月〕大于糖尿病肾病组，Cr高于糖尿病肾病组，体质量小于糖尿病肾病组，空腹血糖低于糖尿病肾病组（P<0.05）。透析龄与性别、年龄、收缩压、舒张压、身高、体质量、双下肢水肿程度、Hb、CRP、Alb、钾、钙、磷、BUN、Cr、iPTH、TC、TG、LDL-C、空腹血糖、超滤量、D/P无直线相关关系（P>0.05）；透析龄与脉搏呈负相关，与HDL-C、eGFR、24 h尿量、总出水量、腹膜KT/V、总KT/V呈正相关（P<0.05）。结论　行CAPD的糖尿病肾病患者透析龄较非糖尿病肾病患者短；脉搏、HDL-C、eGFR、24 h尿量、总出水量、腹膜KT/V、总KT/V与透析龄有关。

关键词: 腹膜透析, 糖尿病, 死亡, 透析龄, 相关分析