Research Progress on the Optimal Exercise Prescription of Metabolic Syndrome and Its Mechanism

doi:10.3969/j.issn.1007-9572.2016.28.026

Abstract

Abstract: Metabolic syndrome (MS) is a group of clinical symptoms,including central obesity,high blood sugar,high blood pressure and dyslipidemia,which influenced human health seriously.Exercises can improve the expression level of adipocytokines,promote the glucose metabolism and secretion function of skeletal muscles,and improve the repairing capacity of damages in vascular endothelium,so as to effectively prevent and improve the metabolic syndrome.Based on recent studies,this paper summarized the most proper exercise prescription for MS from the form of exercise,the frequency and duration of exercises,and intensity of exercises.Future direction was further clarified to provide reference for clinical treatment and relevant scientific research for MS.

Key words: Metabolic syndrome X, Exercise therapy, Mechanism

摘要： 代谢综合征（MS）是中心型肥胖、高血糖、高血压及血脂异常聚集发病的一种临床综合征，严重影响着人类健康。运动可以改善脂肪因子的表达水平、促进骨骼肌的糖代谢和分泌功能、改善血管内皮细胞的损伤修复功能，从而有效预防和切实改善 MS。本文以近期相关研究为基础，主要从运动形式、运动频率与持续时间、运动强度 3 个方面对 MS 的最适运动处方进行综述，并明确其进一步的研究方向，以期为 MS 的临床治疗和相关科研提供参考。

关键词: 代谢综合征 X, 运动疗法, 机制

LIN Le-tao, DONG Ai-mei.. Research Progress on the Optimal Exercise Prescription of Metabolic Syndrome and Its Mechanism[J]. Chinese General Practice, 2016, 19(28): 3509-3512.

林乐涛, 董爱梅. 代谢综合征最适运动处方及其机制的研究进展[J]. 中国全科医学, 2016, 19(28): 3509-3512.

References

［1］GOLBIDI S,MESDAGHINIA A,LAHER I.Exercise in the metabolic syndrome［J］.Oxid Med Cell Longev,2012,2012（18）:349710. ［2］中华医学会糖尿病学分会.中国2型糖尿病防治指南（2013年版）［J］.中华内分泌代谢杂志，2014，30（10）：893-942. Chinese Diabetes Society.Guidelines for prevention and treatment of type 2 diabetes in China（2013）［J］.Chinese Journal of Endocrinology and Metabolism,2014,30（10）:893-942. ［3］SAITO I.Epidemiological evidence of type 2 diabetes mellitus,metabolic syndrome,and cardiovascular disease in Japan［J］.Circ J,2012,76（5）:1066-1073. ［4］吴桂贤，吴兆苏，刘静，等.11省市代谢综合征患者中心脑血管病发病率队列研究［J］.中华流行病学杂志，2003，24（7）：551-553. WU G X,WU Z S,LIU J,et al.A study on the incidence of cardiovascular disease on the metabolic syndrome in 11 provinces in China［J］.Chinese Journal of Epidemiology,2003,24（7）:551-553. ［5］顾东风，REYNOLDS K,杨文杰，等.中国成年人代谢综合征的患病率［J］.中华糖尿病杂志，2005，13（3）：181-186. GU D F,REYNOLDS K,YANG W J,et al.The prevalence of metabolic syndrome in the general adult population aged 35-74 years in China［J］.Chinese Journal of Diabetes,2005,13（3）:181-186. ［6］LACKLAND D T,VOEKS J H.Metabolic syndrome and hypertension:regular exercise as part of lifestyle management［J］.Curr Hypertens Rep,2014,16（11）:492. ［7］程芳洲，刘翔宇.量化运动对代谢综合征干预疗效观察［J］.检验医学与临床，2013，16（1）：6-8. CHENG F Z,LIU X Y.Intervention effect of exercise and diet in the metabolic syndrome［J］.Laboratory Medicine and Clinic,2013,16（1）:6-8. ［8］PATTYN N,CORNELISSEN V A,ESHGHI S R,et al.The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome:a meta-analysis of controlled trials［J］.Sports Med,2013,43（2）:121-133. ［9］STRAZNICKY N E,GRIMA M T,LAMBERT E A,et al.Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals［J］.J Hypertens,2011,29（3）:553-564. ［10］程芳洲，刘翔宇.量化运动对代谢综合征干预效果及血清脂肪细胞因子水平影响［J］.现代预防医学，2013，40（9）：1690-1692，1695. CHENG F Z,LIU X Y.Intervention effect of exercise in the metabolic syndrome and the influence on the adipocytokine［J］.Modern Preventive Medicine,2013,40（9）:1690-1692,1695. ［11］FEOLI A M,MACAGNAN F E,PIOVESAN C H,et al.Xanthine oxidase activity is associated with risk factors for cardiovascular disease and inflammatory and oxidative status markers in metabolic syndrome:effects of a single exercise session［J］.Oxid Med Cell Longev,2014:587083. ［12］STENSVOLD D,SLORDAHL S A,WISLOFF U.Effect of exercise training on inflammation status among people with metabolic syndrome［J］.Metab Syndr Relat Disord,2012,10（4）:267-272. ［13］沈玄霖，刘遂心.有氧运动对代谢综合征患者的疗效观察及其机制研究［J］.中国医师杂志，2012，14（9）：1175-1178. SHEN X L,LIU S X.Studies on the effect and mechanism of aerobic exercise on patients with metabolic syndrome［J］.Journal of Chinese Physician,2012,14（9）:1175-1178. ［14］詹晓梅，邱珍艳，陈文鹤.肥胖与2型糖尿病患者内脂素水平及运动干预效果评价［J］.中国运动医学杂志，2012，31（7）：627-635. ZHAN X M,QIU Z Y,CHEN W H.Evaluation of the exercise intervention effect on the visfatin level of the obesity and type 2 diabetes mellitus patients［J］.Chinese Journal of Sports Medicine,2012,31（7）:627-635. ［15］STASTNY J,BIENERTOVA-VASKU J,VASKU A.Visfatin and its role in obesity development［J］.Diabetes Metab Syndr,2012,6（2）:120-124. ［16］STANFORD K I,GOODYEAR L J.Exercise and type 2 diabetes:molecular mechanisms regulating glucose uptake in skeletal muscle［J］.Adv Physiol Educ,2014,38（4）:308-314. ［17］RICHTER E A,HARGREAVES M.Exercise,GLUT4,and skeletal muscle glucose uptake［J］.Physiol Rev,2013,93（3）:993-1017. ［18］NIELSEN A R,PEDERSEN B K.The biological roles of exercise-induced cytokines:IL-6,IL-8,and IL-15［J］.Appl Physiol Nutr Metab,2007,32（5）:833-839. ［19］PEAKE J M,DELLA G P,SUZUKI K,et al.Cytokine expression and secretion by skeletal muscle cells:regulatory mechanisms and exercise effects［J］.Exerc Immunol Rev,2015,21:8-25. ［20］BOSTROM P,WU J,JEDRYCHOWSKI M P,et al.A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis［J］.Nature,2012,481（7382）:463-468. ［21］田文葭.2型糖尿病患者血清irisin水平及其与胰岛素抵抗相关性的研究［D］.杭州：浙江大学，2015. ［22］HUH J Y,SIOPI A,MOUGIOS V,et al.Irisin in response to exercise in humans with and without metabolic syndrome［J］.J Clin Endocrinol Metab,2015,100（3）:453-457. ［23］艾华，谢岚.运动对鸢尾素影响研究进展［J］.中国运动医学杂志，2014，33（12）：1201-1206. AI H,XIE L.Progress in research on the effect of exercise on irisin［J］.Chinese Journal of Sports Medicine,2014,33（12）:1201-1206. ［24］鲁志炜，张家贵，吕义兰.代谢综合征患者有氧运动前后血管内皮功能的研究［J］.中华临床医师杂志：电子版，2012，6（23）：7817-7819.DOI：10.3877/cma.j.issn.1674-0785.2012.23.066 LU Z W,ZHANG J G,LYU Y L.Study on endothelial function in patients with metabolic syndrome before and after aerobic exercise［J］.Chinese Journal of Clinicians：Electronic Edition,2012,6（23）:7817-7819.DOI：10.3877/cma.j.issn.1674-0785.2012.23.066 ［25］DONLEY D A,FOURNIER S B,REGER B L,et al.Aerobic exercise training reduces arterial stiffness in metabolic syndrome［J］.J Appl Physiol,2014,116（11）:1396-1404. ［26］SONNENSCHEIN K,HORVATH T,MUELLER M,et al.Exercise training improves in vivo endothelial repair capacity of early endothelial progenitor cells in subjects with metabolic syndrome［J］.Eur J Cardiovasc Prev Rehabil,2011,18（3）:406-414. ［27］YANG Z,SCOTT C A,MAO C,et al.Resistance exercise versus aerobic exercise for type 2 diabetes:a systematic review and meta-analysis［J］.Sports Med,2014,44（4）:487-499. ［28］PARK S Y,KWAK Y S,HARVESON A,et al.Low intensity resistance exercise training with blood flow restriction:insight into cardiovascular function,and skeletal muscle hypertrophy in humans［J］.Korean J Physiol Pharmacol,2015,19（3）:191-196. ［29］ROBERTS C K,HEVENER A L,BARNARD R J.Metabolic syndrome and insulin resistance:underlying causes and modification by exercise training［J］.Compr Physiol,2013,3（1）:1-58. ［30］KIM T N,PARK M S,LIM K I,et al.Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness:the Korean Sarcopenic Obesity Study（KSOS）［J］.Diabetes Res Clin Pract,2011,93（2）:285-291. ［31］American Diabetes Association’s.Standards of medical care in diabetes——2014［J］.Diabetes Care,2014,37:S14-80. ［32］SALAS-ROMERO R,SANCHEZ-MUNOZ V,FRANCO-SANCHEZ J G,et al.Effectiveness of two aerobic exercise programs in the treatment of metabolic syndrome:a preliminary study［J］.Gac Med Mex,2014,150（6）:490-498. ［33］张忍发，李军，杨敏丽.不同运动方案对代谢综合征干预的效果比较［J］.昆明医科大学学报，2014，35（4）：87-90. ZHANG R F,LI J,YANG M L.Comparison of effects of different interventions of exercise program on metabolic syndrome［J］.Journal of Kunming Medical University,2014,35（4）:87-90. ［34］CHURCH T S,EARNEST C P,SKINNER J S,et al.Effects of different doses of physical activity on cardiorespiratory fitness among sedentary,overweight or obese postmenopausal women with elevated blood pressure:a randomized controlled trial［J］.JAMA,2007,297（19）:2081-2091. ［35］EARNEST C P,JOHANNSEN N M,SWIFT D L,et al.Dose effect of cardiorespiratory exercise on metabolic syndrome in postmenopausal women［J］.Am J Cardiol,2013,111（12）:1805-1811. ［36］高峰，崔文丽，焦广发，等.代谢综合征运动处方制定的新模式——最大脂代谢强度运动处方［J］.中国运动医学杂志，2012，31（9）：835-838. GAO F,CUI W L,JIAO G F,et al.A new model for the exercise prescription of metabolic syndrome:the exercise prescription of maximal lipid metabolism［J］.Chinese Journal of Sports Medicine,2012,31（9）:835-838. ［37］MAURIE J,BRUN J F,JEAN E,et al.Comparison of Square Wave Endurance Exercise Test（SWEET） training with endurance training targeted at the level of maximal lipid oxidation in type 2 diabetics［J］.Science & Sports,2011,26:92-96. ［38］DUTHEIL F,LAC G,LESOURD B,et al.Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome:the RESOLVE randomized trial［J］.Int J Cardiol,2013,168（4）:3634-3642. ［39］GAUDREAULT V,DESPRES J P,RHEAUME C,et al.Exercise-induced hypertension in men with metabolic syndrome:anthropometric,metabolic,and hemodynamic features［J］.Metab Syndr Relat Disord,2013,11（1）:7-14.

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