Vascular endothelial growth factor signaling pathway (VSP) inhibitors have gradually increased and been widely used recently, with a high incidence of inducing hypertension adverse events. VSP inhibitor induced hypertension is difficult to diagnose in a timely and the management of uncontrolled blood pressure is neglected, active blood pressure management strategies are essential. This paper summarized the status of VSP inhibitors treatment and its related hypertension, as well as the blood pressure management strategies for VSP inhibitor-related hypertension. The aim was to increase the awareness of VSP inhibitor-related hypertension among healthcare professionals and provide blood pressure management strategies for patients using VSP inhibitors to improve blood pressure control and cardiovascular health.

近年来，血管内皮生长因子信号通路抑制剂类药物逐渐增多且应用广泛，其诱发的高血压不良事件发生率较高。血管内皮生长因子信号通路抑制剂诱发高血压难以被及时诊断且未受控制的高血压疏于管理，因此，积极的血压管理策略是十分必要的。本文总结了血管内皮生长因子信号通路抑制剂治疗及其相关高血压的现状、血管内皮生长因子信号通路抑制剂相关高血压的血压管理策略，旨在提高医护人员对血管内皮生长因子信号通路抑制剂相关高血压的重视，并为应用血管内皮生长因子信号通路抑制剂患者提供血压管理策略，以改善患者的血压控制和心血管健康。