Recent Advances in Soluble Prorenin Receptor in Multisystem Diseases

doi:10.12114/j.issn.1007-9572.2022.0503

Abstract

Abstract:

Previous studies on renin-angiotensin-aldosterone system (RAAS) mainly focus on renin, prorenin and prorenin receptor (PRR), which play an important role in cardiovascular, renal and other diseases. The physiological function of PRR has been widely studied. Soluble prorenin receptor (sPRR) is generated by cleavage of extracellular components of PRR by protease and secreted into extracellular space, therefore the change of sPRR level may reflect the change of RAAS in tissue. However, there are limited clinical researchs on sPRR. In recent years, increasing evidences show that sPRR has important biological functions in various pathophysiological processes. This article summarized the recent advances in sPRR in cardiovascular system, kidney diseases, respiratory diseases, endocrine and metabolic diseases, pregnancy complications and cancers, and considered that sPRR may be a new biomarker of multiple diseases, and has potential therapeutic effects on metabolic diseases.

Key words: Nephrosis, Renin, Renin-angiotensin system, Cardiovascular diseases, Soluble prorenin receptor, Multisystem diseases, Review

摘要：

既往关于肾素-血管紧张素-醛固酮系统（RAAS）的研究以在心血管、肾脏等疾病中发挥重要作用的肾素、肾素前体、肾素前体受体（PRR）为主，其中PRR的生理功能已被广泛研究。可溶性肾素前体受体（sPRR）是通过蛋白酶切割PRR的细胞外成分产生，并分泌到细胞外空间，因此sPRR水平的变化有可能反映组织RAAS的变化，然而临床对sPRR的相关研究有限。近年来越来越多的研究证据表明，sPRR在多种病理生理过程中具有重要的生物学功能，因此本文总结了sPRR在心血管疾病、肾脏疾病、呼吸系统疾病、内分泌和代谢性疾病、妊娠并发症、癌症等方面的最新研究进展，认为sPRR可能是多种疾病的新型生物标志物，并对代谢性疾病等具有潜在的治疗效果。

关键词: 肾病, 肾素, 肾素-血管紧张素系统, 心血管疾病, 可溶性肾素前体受体, 多系统疾病, 综述

LI Mengye,JIANG Yinong. Recent Advances in Soluble Prorenin Receptor in Multisystem Diseases[J]. Chinese General Practice, 2024, 27(18): 2295-2300. DOI: 10.12114/j.issn.1007-9572.2022.0503.
李孟野,姜一农. 可溶性肾素前体受体在多系统疾病中的研究进展[J]. 中国全科医学, 2024, 27(18): 2295-2300. DOI: 10.12114/j.issn.1007-9572.2022.0503.

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