Drinking sugary drinks are common in China, but inadequate intake of which can induce a variety of diseases. Many studies have reported the relationship between intake of sugary drinks and the risk of hypertension, however, there are still disputes over the specific dose-response relationship between them.

To assess the dose-response relationship between the intake of sugary drinks and the risk of hypertension.

We searched for cross-sectional and prospective studies about the intake of sugary drinks and risk of hypertension in databases of CNKI, CQVIP, SinoMed, Wanfang Data, PubMed, EMBase, Cochrane Library, and Web of Science from inception to November 2021. Two reviewers independently extracted data, and evaluated the quality of included studies. Stata 16.0 was used for meta-analysis.

Sixteen studies with 316 205 subjects were included. Meta-analysis results showed that the intake of sugary drinks increased the risk of hypertension〔OR=1.12, 95%CI (1.10, 1.15) , P<0.05 〕. Subgroup analyses revealed that by the intake of sugary drinks, the risk of hypertension increased by 34% in Asian population〔OR=1.34, 95%CI (1.20, 1.51) , P<0.05〕, and increased by 11% in North American population〔OR=1.11, 95%CI (1.09, 1.14) , P<0.05〕, and rose by 82% in Oceanian population〔OR=1.82, 95%CI (1.04, 3.21) , P<0.05〕, and grew by 18% in European population〔OR=1.18, 95%CI (1.02, 1.36) , P<0.05〕. Furthermore, the intake of sugary drinks was associated with a 43% higher risk of hypertension in minors〔OR=1.43, 95%CI (1.21, 1.69) , P<0.05〕, and a 12% higher risk of hypertension in adults〔OR=1.12, 95%CI (1.09, 1.15) , P<0.05〕 . In addition, the intake of sugary drinks was associated with a 12% higher risk of hypertension in people with normal BMI〔OR=1.12, 95%CI (1.09, 1.15) , P<0.05〕, a 17% higher risk of hypertension in overweight people〔OR=1.17, 95%CI (1.00, 1.38) , P<0.05〕, and a 19% higher risk of hypertension in obese people〔OR=1.19, 95%CI (1.06, 1.34) , P<0.05〕. Dose-response analysis results showed that for every additional sugary drink (i.e. 12 ounces, about 340 g or 355 ml) per day, the risk of hypertension increases by 16%〔OR=1.16, 95%CI (1.13, 1.18) , P<0.05〕. The basically symmetrical funnel plot and the Begg's test (Z=0.23, P>0.05) and Egger's test (t=1.46, P>0.05) showed no published bias.

The intake of sugary drinks may be associated with increased risk of hypertension, and for every increased intake of a sugary drink (i.e. 12 ounces, about 340 g or 355 ml) per day, the risk of hypertension increased by 16%. So controlling the intake of sugar is important for preventing hypertension.

饮用含糖饮料现象在我国普遍存在，摄入过多可诱发多种疾病的发生。国内外多项研究报道了摄入含糖饮料与高血压发病风险的关系，但在具体摄入剂量与发病风险方面仍存在争议。

分析含糖饮料摄入与高血压发病风险的剂量反应关系。

计算机检索中国知网、维普网、中国生物医学文献服务系统、万方数据知识服务平台、PubMed、EMBase、Cochrane Library、Web of Science中有关含糖饮料摄入与高血压发病风险的横断面研究和前瞻性研究，检索时限自建库至2021年11月。由2位研究者分别单独对文献数据独立提取，并进行文献质量评价，采用Stata 16.0软件进行Meta分析。

共纳入16篇文献，316 205例研究对象。Meta分析结果显示，含糖饮料摄入增加高血压的发病风险〔OR=1.12，95%CI（1.10，1.15），P<0.05〕。亚组分析结果显示，亚洲人群含糖饮料摄入增加34%的高血压发病风险〔OR=1.34，95%CI（1.20，1.51），P<0.05〕，北美洲人群含糖饮料摄入增加11%的高血压发病风险〔OR=1.11，95%CI（1.09，1.14），P<0.05〕，大洋洲人群含糖饮料摄入增加82%的高血压发病风险〔OR=1.82，95%CI（1.04，3.21），P<0.05〕，欧洲人群含糖饮料摄入增加18%的高血压发病风险〔OR=1.18，95%CI（1.02，1.36），P<0.05〕；未成年人含糖饮料摄入增加43%的高血压发病风险〔OR=1.43，95%CI（1.21，1.69），P<0.05〕，成年人含糖饮料摄入增加12%的高血压发病风险〔OR=1.12，95%CI（1.09，1.15），P<0.05〕；体质指数（BMI）正常者含糖饮料摄入增加12%的高血压发病风险〔OR=1.12，95%CI（1.09，1.15），P<0.05〕，超重者含糖饮料摄入增加17%的高血压发病风险〔OR=1.17，95%CI（1.00，1.38），P<0.05〕，肥胖者含糖饮料摄入增加19%的高血压发病风险〔OR=1.19，95%CI（1.06，1.34），P<0.05〕。剂量反应分析结果显示，每天每增加1份含糖饮料（即12盎司，约为340 g或355 ml）的摄入，高血压发病风险增加16%〔OR=1.16，95%CI（1.13，1.18），P<0.05〕。文献的漏斗图显示基本对称，Begg's检验（Z=0.23，P>0.05）和Egger's检验（t=1.46，P>0.05）显示无发表偏倚。

含糖饮料摄入会增加高血压的发病风险，且每天每增加1份含糖饮料（即12盎司，约为340 g或355 ml）的摄入，高血压发病风险增加16%，控制含糖量对预防高血压有重要意义。