Moxibustion on Governor Vessel Acupoints Improves the Cognitive Function and TCM Symptoms in Patients with Post-stroke Mild Cognitive Impairment Due to Deficiency of Kidney Essence

doi:10.12114/j.issn.1007-9572.2021.02.113

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (12): 1487-1492,F01.DOI: 10.12114/j.issn.1007-9572.2021.02.113

Special Issue: 泌尿系统疾病最新文章合辑；神经退行性病变最新文章合辑；阿尔茨海默病最新文章合辑；神经系统疾病最新文章合辑；中医最新文章合辑；脑健康最新研究合辑

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Moxibustion on Governor Vessel Acupoints Improves the Cognitive Function and TCM Symptoms in Patients with Post-stroke Mild Cognitive Impairment Due to Deficiency of Kidney Essence

¹School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
²Rehabilitation Center, the First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China

Received:2021-09-30 Revised:2021-11-13 Published:2021-11-18 Online:2022-03-21
Contact: Yanjie BAI
About author:
WANG Y, BAI Y J, ZHANG M, et al. Moxibustion on Governor vessel acupoints improves the cognitive function and TCM symptoms in patients with post-stroke mild cognitive impairment due to deficiency of kidney essence [J] . Chinese General Practice, 2022, 25 (12) : 1487-1492.

艾灸督脉对肾精亏虚型卒中后轻度认知障碍患者认知功能和中医症状的临床疗效研究

¹450046　河南省郑州市，河南中医药大学康复医学院
²450000　河南省郑州市，河南中医药大学第一附属医院康复中心

通讯作者: 白艳杰
作者简介:
王岩，白艳杰，张铭，等.艾灸督脉对肾精亏虚型卒中后轻度认知障碍患者认知功能和中医症状的临床疗效研究[J].中国全科医学，2022，25（12）：1487-1492. [www.chinagp.net] 作者贡献：王岩提出研究选题方向，负责设计研究方案及确定研究方法，同时负责数据分析与统计学处理及对统计结果进行解释，撰写论文初稿；李晓晓、张雍负责研究方案实施，收集、整理临床资料，提供数据；白艳杰负责论文最终稿的修订、论文的质量控制及审校，对论文整体负责，监督管理；所有作者确认了论文的最终稿。
基金资助:
国家重点研发计划项目(2018YFC1706004); 河南省中医药科学研究专项重点课题(20-21ZY1009); 河南省中医药拔尖人才培养项目(CZ0237-08)

Abstract

Abstract:

Background

Post-stroke mild cognitive impairment (PSMCI) is a common complication after stroke, which negatively affects patients' full recovery from stroke and imposes financial and emotional pressure on their families.

Objective

To observe the clinical efficacy of moxibustion on Governor vessel on the cognitive function and TCM syndromes in PSMCI due to deficiency of kidney essence.

Methods

Eligible patients with PSMCI (n=60) who were treated in Rehabilitation Center, the First Affiliated Hospital of Henan University of CM from July 2020 to July 2021 were selected, and evenly randomized to a control group (routine basic treatment plus routine cognitive rehabilitation training) and a moxibustion group 〔routine basic treatment plus routine cognitive rehabilitation training and moxibustion on the Governor vessel acupoints (once daily, five times per week) 〕, received four consecutive weeks of treatment. The Mini-Mental State Examination (MMSE) , and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive function. Symptoms of kidney essence deficiency was assessed by the Scale for the Differentiation of Syndromes of Vascular Dementia (SDSVD) . And quality of life was measured by the Specifications for Stroke-Quality of Life (SS-QOL) . The overall clinical efficacy and safety of the two treatments were evaluated.

Results

Pre- and post-treatment comparisons of scores of MMSE and MoCA, SDSVD, and SS-QOL revealed that moxibustion group patients group had greater improvements in cognitive function, symptoms of kidney essence deficiency, and quality of life than control group patients (P<0.05) . Moreover, moxibustion group patients had better clinical outcomes (P<0.05) . The safety of treatment showed no significant intergroup differences (P>0.05) .

Conclusion

Moxibustion of the Governor vessel helps to better improve the cognitive function and TCM symptoms of PSMCI patients due to deficiency of kidney essence with good clinical efficacy and safety.

Key words: Stroke, Cognitive dysfunction, Moxa stick moxibustion, Points, Governor vessel, Kidney-essence deficiency, Cognition, TCM therapy, Treatment outcome

摘要：

背景

卒中后轻度认知障碍（PSMCI）是卒中后患者常见并发症，影响患者全面康复的同时也给其家庭带来了经济和精神方面的压力。

目的

观察艾灸督脉对肾精亏虚型PSMCI患者认知功能及中医症状的临床疗效。

方法

选取2020年7月至2021年7月河南中医药大学第一附属医院康复中心收治的符合纳入标准的PSMCI患者60例为研究对象，采用随机数字表法将其分为艾灸组和对照组，每组30例。对照组患者给予常规基础治疗及常规认知功能康复训练，艾灸组患者在对照组基础上进行艾灸督脉治疗，1次/d，5次/周，持续4周。比较治疗前后两组患者简易智能精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）、血管性痴呆中医辨证量表（SDSVD）中肾精亏虚型和脑卒中专用生活质量量表（SS-QOL）评分，并评定两组治疗的临床疗效和安全性。

结果

艾灸组患者治疗前后MMSE、MoCA、SDSVD、SS-QOL评分差值大于对照组（P<0.05）。艾灸组患者治疗后临床疗效优于对照组（P<0.05）。两组患者治疗安全性比较，差异无统计学意义（P>0.05）。

结论

艾灸督脉可以改善PSMCI患者的认知功能和中医症状，临床疗效佳，且安全性较好。

关键词: 卒中, 认知功能障碍, 艾条灸, 穴位，督脉, 肾精不足, 认知, 中医疗法, 治疗结果

Yan WANG,Yanjie BAI,Ming ZHANG, et al. Moxibustion on Governor Vessel Acupoints Improves the Cognitive Function and TCM Symptoms in Patients with Post-stroke Mild Cognitive Impairment Due to Deficiency of Kidney Essence[J]. Chinese General Practice, 2022, 25(12): 1487-1492,F01. DOI: 10.12114/j.issn.1007-9572.2021.02.113.
王岩,白艳杰,张铭等. 艾灸督脉对肾精亏虚型卒中后轻度认知障碍患者认知功能和中医症状的临床疗效研究[J]. 中国全科医学, 2022, 25(12): 1487-1492,F01. DOI: 10.12114/j.issn.1007-9572.2021.02.113.

Figures/Tables 7

References 29

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组别	例数	年龄（±s，岁）	性别（男/女）	病程（±s，d）	卒中类型（出血性/缺血性）	受教育时间（±s，年）
对照组	30	63.8±3.0	19/11	68.6±14.8	20/10	15.7±1.7
艾灸组	30	64.3±2.9	22/8	68.5±8.6	13/17	15.6±1.3
χ²（t）值		-0.612^a	0.693	0.043^a	3.300	0.429^a
P值		0.543	0.405	0.966	0.069	0.669

组别	例数	年龄（±s，岁）	性别（男/女）	病程（±s，d）	卒中类型（出血性/缺血性）	受教育时间（±s，年）
对照组	30	63.8±3.0	19/11	68.6±14.8	20/10	15.7±1.7
艾灸组	30	64.3±2.9	22/8	68.5±8.6	13/17	15.6±1.3
χ²（t）值		-0.612^a	0.693	0.043^a	3.300	0.429^a
P值		0.543	0.405	0.966	0.069	0.669

组别	例数	显效	有效	无效
对照组	30	0	17（56.7）	13（43.3）
艾灸组	30	13（43.3）	16（53.3）	1（3.4）
Z值		4.769
P值		<0.001

组别	例数	显效	有效	无效
对照组	30	0	17（56.7）	13（43.3）
艾灸组	30	13（43.3）	16（53.3）	1（3.4）
Z值		4.769
P值		<0.001

组别	例数	1级	2级	3级	4级
对照组	30	26（86.7）	4（13.3）	0	0
艾灸组	30	23（76.7）	7（23.3）	0	0
Z值		-0.993
P值		-0.321

Moxibustion on Governor Vessel Acupoints Improves the Cognitive Function and TCM Symptoms in Patients with Post-stroke Mild Cognitive Impairment Due to Deficiency of Kidney Essence

艾灸督脉对肾精亏虚型卒中后轻度认知障碍患者认知功能和中医症状的临床疗效研究

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组别	例数	治疗前	治疗后
对照组	30	23.0（23.0，24.0）	26.0（25.0，26.0）
艾灸组	30	23.0（22.8，23.0）	27.0（27.0，28.0）

组别	例数	治疗前	治疗后
对照组	30	21.0（21.0，22.0）	24.00（23.0，25.0）
艾灸组	30	21.0（20.0，22.0）	26.00（25.0，27.0）

组别	例数	治疗前	治疗后
对照组	30	11.5（9.8，13.0）	9.5（8.8，10.2）
艾灸组	30	10.0（9.8，11.0）	8.0（7.0，8.0）

组别	例数	治疗前	治疗后
对照组	30	132.5（127.0，138.5）	166.0（161.8，174.2）
艾灸组	30	135.0（124.8，143.2）	201.0（192.8，205.2）

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