Abstract: Background　Functional dyspepsia （FD） is a common and frequently-occurring digestive disease in China.Previous studies paid little attention to the clinically measured peripheral blood indicators of patients.Objective　To observe and analyze the differences of peripheral blood leukocytes between FD patients and normal healthy people.Methods　We enrolled 172 cases from China-Japan Friendship Hospital from 2016 through 2018，including 87 outpatients with a definite diagnosis of FD from Department of Spleen and Stomach Diseases，and 45 normal health people（consisting of workers and physical examinees in this hospital）.We collected and compared the values and rates of abnormalities of peripheral blood leukocyte count，neutrophil count，neutrophil percentage，eosinophil count between the groups，and conducted a sex-based analysis of white blood cells between the groups.Results　The proportion of women in FD group was higher than that in control group（P<0.05）.Abnormal leukocyte counts were found in 15 FD patients and one control，which were slightly lower than the normal reference range.Abnormal neutrophil percentage was found in 16 FD patients and one control，which was also slightly lower than the normal reference range.Abnormal percentage of neutrophils was detected in four FD patients（decreased slightly in one and elevated slightly in three） and three controls（slightly decreased in two and slightly elevated in one）.Abnormal eosinophil count was found in two FD patients and one control，all elevated slightly.FD patients had higher rate of abnormalities and lower average level of white blood cell count（P<0.05）.Moreover，they also had higher rate of abnormalities and lower average level of neutrophil count（P<0.05）.The average levels of leukocyte and neutrophil counts in female FD patients were significantly lower than those of female controls（P<0.05）.Conclusion　PD patients，especially female PD patients，may be more prone to abnormalities and decline in leukocyte and neutrophil counts.

Key words: Dyspepsia, Leukocytes, Neutropenia, Inflammation, Immune activation

摘要： 背景　功能性消化不良（FD）是我国消化系统的常见病、多发病，既往研究较少关注患者的临床检验指标。目的　观察FD患者外周血白细胞情况，并分析其与健康者之间的差异。方法　选取2016—2018年就诊于中日友好医院脾胃病科门诊且确诊为FD的患者为FD组（n=87），选取同期于本院工作的健康职工及行体检的健康志愿者为对照组（n=45）。收集两组外周血白细胞计数、中性粒细胞计数、中性粒细胞分数、嗜酸粒细胞计数情况，进行异常率和具体数值的比较；并对两组不同性别的人群进行白细胞分析。结果　FD组女性所占比例高于对照组（P<0.05）。FD组白细胞计数异常者15例，均表现为偏低；对照组白细胞总数异常者1例，也表现为偏低。FD组中性粒细胞计数异常者16例，均表现为偏低；对照组中性粒细胞计数异常者1例，也表现为偏低。FD组中性粒细胞分数异常者4例，其中1例表现为偏低，3例表现为偏高；对照组中性粒细胞分数异常者3例，其中2例表现为偏低，1例表现为偏高。FD组嗜酸粒细胞计数异常者2例，均表现为偏高；健康组嗜酸粒细胞计数异常者1例，表现为偏高。FD组白细胞计数、中性粒细胞计数异常率高于对照组（P<0.05）。FD组白细胞计数、中性粒细胞计数低于对照组（P<0.05）。女性FD患者白细胞计数、中性粒细胞计数低于健康女性（P<0.05）。结论　FD患者白细胞计数及中性粒细胞计数较健康人群偏低，白细胞计数、中性粒细胞计数异常率较健康人群高，且这种现象在女性FD患者中更突出。

关键词: 消化不良, 白细胞, 中性粒细胞减少, 炎症, 免疫激活