Effects of Long-term Blood Pressure Variability on Arteriosclerosis

doi:10.12114/j.issn.1007-9572.2021.00.060

Abstract

Abstract: Background　Long-term blood pressure variability（BPV）is an important independent risk factor for cardiovascular disease.It is unclear how long-term BPV contributes to the development of cardiovascular disease.There are no studies on the relationship between long-term BPV and arterial stiffness in China.Objective　To investigate the effect of long-term BPV on arteriosclerosis.Methods　A total of 21 420 eligible workers of Kailuan Group who attended annual staff physical examinations（2006，2008 and 2010）with complete data of examinations were recruited.Data were collected，such as body mass index（BMI），low-density lipoprotein（LDL），high-density lipoprotein（HDL），fasting blood glucose（FBG），blood pressure，brachial-ankle pulse wave velocity（baPWV），and calculated standard deviation of systolic blood pressure（SBP_SD）.The differences across tertiles groups of SBP_SD〔low SBP_SD group（n=7 188），medium SBP_SD group（n=7 102），and high SBP_SD group（n=7 130）〕 were analyzed.The relationship between SBP_SD and baPWV was analyzed by multiple linear regression.Multivariate Logistic regression analysis was used to investigate the association of SBP_SD with arteriosclerosis.Results　Compared with low SBP_SD group，medium SBP_SD group had greater average age，higher average SBP_SD，baPWV，BMI，FBG and LDL，and higher average SBP in 2006，2008 and 2010（P<0.05），and high SBP_SD group showed higher average SBP_SD，baPWV，BMI，hear rate，FBG and LDL，and higher average SBP in 2006，2008 and 2010（P<0.05）.Multiple linear regression analysis showed that SBP_SD was an influential factor of baPWV（P<0.05）.Multivariate logistic regression analysis showed that SBP_SD was an influential factor in the occurrence of arteriosclerosis（P<0.05）.SBP_SD remained an influential factor in baPWV and the development of arteriosclerosis in both non-hypertensive and hypertensive groups（P<0.05）.Conclusion　Long-term BPV may be a risk factor for arteriosclerosis，which may cause arteriosclerosis.

Key words: Arterioselerosis, Long-term blood pressure variability, Cardiovascular diseases, Cerebrovascular diseases, Standard deviation of systolic blood pressure, Root cause analysis

摘要： 背景　长时血压变异性是心脑血管疾病重要的独立危险因素，目前长时血压变异性如何导致心脑血管疾病的发生发展尚不明确，且国内尚未见有关长时血压变异性与动脉硬化关系的研究。目的　探究长时血压变异性对动脉硬化的影响。方法　选取完成2006、2008、2010年度开滦集团健康体检以及臂踝脉搏波传导速度（baPWV）测量的21 420例体检者为调查对象，收集其体质指数（BMI）、心率（HR）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、空腹血糖（FBG）、血压、baPWV，并计算收缩压标准差（SBP_SD）。将调查对象按SBP_SD情况分为第一分位组（7 188例）、第二分位组（7 102例）、第三分位组（7 130例），比较组间异质性，通过多元线性回归分析SBP_SD与baPWV的关系，采用多因素Logistic回归分析探讨不同SBP_SD水平对动脉硬化发生的影响。结果　第二分位组调查对象年龄、SBP_SD、baPWV、BMI、2006年度收缩压（SBP06）、2008年度收缩压（SBP08）、2010年度收缩压（SBP10）、FBG、LDL水平高于第一分位组，第三分位组调查对象年龄、SBP_SD、baPWV、BMI、HR、SBP06、SBP08、SBP10、FBG、LDL水平高于第一分位组和第二分位组（P<0.05）。多元线性回归分析显示，SBP_SD是baPWV的影响因素（P<0.05）。多因素Logistic回归分析显示，SBP_SD是发生动脉硬化的影响因素（P<0.05）。且在非高血压人群及高血压人群中，SBP_SD仍是baPWV及发生动脉硬化的影响因素（P<0.05）。结论　长时血压变异性可能导致动脉硬化的发生，是动脉硬化的危险因素。

关键词: 动脉硬化, 长时血压变异性, 心血管疾病, 脑血管疾病, 收缩压标准差, 影响因素分析

WU Aiping,MA Yihan,LI Xingyu, et al. Effects of Long-term Blood Pressure Variability on Arteriosclerosis　[J]. Chinese General Practice, 2021, 24(2): 148-153. DOI: 10.12114/j.issn.1007-9572.2021.00.060.
武爱萍,马一涵,李兴雨等. 长时血压变异性对动脉硬化的影响研究[J]. 中国全科医学, 2021, 24(2): 148-153. DOI: 10.12114/j.issn.1007-9572.2021.00.060.

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