Relationship between Gene-environment Interaction and Hypertension and Its Implications for Community Management

doi:10.12114/j.issn.1007-9572.2020.00.521

Abstract

Abstract: Hypertension is a complicated disease affected by both gene-gene and gene-environment interactions.Risk factors for hypertension mainly consist of environmental（lifestyle）and genetic factors.Previous genome-wide association studies have indicated the polygenic complexity of hypertension.We summarized the recent advances in gene-environmental interactions in hypertension，finding that non-drug therapy is the basic approach to hypertension.However，whether using drug therapy or not，these patients should maintain a healthy lifestyle，including a healthy diet，quitting smoking，moderate alcohol consumption，improving sleep，and exercising regularly.Although several gene mutation sites associated with hypertension have been found，further experimental studies are needed to explore the regulatory mechanisms of hypertension-related genes.

Key words: Hypertension, Gene, Disorders of environmental origin, Environmental factor, Community health services

摘要： 高血压是一种基因与基因之间以及基因与环境因素交互作用的复杂疾病，其危险因素包括环境因素（生活方式因素）和遗传因素。全基因组关联研究表明了高血压的多基因复杂性。因此，本文总结了近年来基因-环境因素相互作用在高血压中的研究进展，发现非药物治疗是降压治疗的基本措施，无论是否选择药物治疗，均要保持良好的生活方式，如合理饮食、戒烟限酒、改善睡眠、规律运动。虽然目前已经发现了许多与高血压发病相关的基因变异位点，但要进一步深入了解高血压相关基因的调控机制，仍需开展更多实验研究。

关键词: 高血压, 基因, 环境因素诱发疾病, 环境因素, 社区卫生服务

SHI Yuncong,WANG Lili,GUO Yifang. Relationship between Gene-environment Interaction and Hypertension and Its Implications for Community Management　[J]. Chinese General Practice, 2021, 24(2): 138-142. DOI: 10.12114/j.issn.1007-9572.2020.00.521.
史云聪,王立立,郭艺芳. 基因-环境因素相互作用与高血压的关系及其对社区管理的建议[J]. 中国全科医学, 2021, 24(2): 138-142. DOI: 10.12114/j.issn.1007-9572.2020.00.521.

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