Abstract: Background　Inappropriate polypharmacy，especially in older people，imposes substantial burden of adverse drug events，illness，disability，hospitalization and even death.Deprescribing is the process of tapering or stopping drugs，aimed at minimizing polypharmacy and improving patient outcomes.Objective　To search and analyze theoriginal researches on deprescribing from 2013 to 2018 in Web of Science，and to explore the literature distribution and research focus.Methods　The retrieval date was October 10，2018.We searched medical subject headings in Web of Science Core Collection Databases，set the date ranged from 2003 to 2018 and the search formula was as follows：subject=（"deprescribing"） OR topic=（"deprescribe"）．Firstly，the retrieved literature were screened according to the inclusion criteria.Then the included literature were analyzed by bibliometric through EndNote 8.0 and the analysis and retrieval tools in Web of Science.Results　A total of 70 original research papers were included in the study.From 2012 to 2014，two articles about deprescribing were published（accounting for 2.9%）．The number of published articles began to increase and 5 articles（accounting for 7.1%） were published in 2015.From January 2016 to October 2018，the number of published articles increased rapidly 〔a total of 63 articles（accounting for 90.0%）〕.BMJ Open and European Journal of Hospital Pharmacy Science and Practice published the largest number of papers（each with 5 papers），and seven SCI journals published three or more papers each.In addition，BMC Medicine had the highest influence factor（IF=9.08）．There were 21 highly cited papers（citation≥7）．The included literature were from 17 countries and regions，among which Canada，Australia and the United States were the three countries with the largest number of publications.The average author cooperation degree of the literature was 5.4，that is，each paper has an average of 5-6 authors.And the average institutional cooperation degree was 3.0，that is，an average of three institutions participated in the research of each paper.The analysis of the occupational distribution of the first authors showed that most of them were clinical pharmacists，public health scholars and general practitioners.And the research disciplines of the included literature were mainly pharmacy and internal medicine，followed by geriatrics.Conclusion　Although research on deprescribing is still at an early stage，it has become a research focus.The number of published literature has increased rapidly since 2016 and Canadian，Australian and American scholars have published the most number of papers.The first authors of published literature were mainly pharmacists，public health researchers and general practitioners.

Key words: 　Bibliometrics, Deprescribing, Web of Science, Aged, Multiple drug use

摘要： 背景　不合理的多重用药，特别是在老年人群中，会带来严重后果，包括药物不良反应、疾病、残疾、住院甚至死亡。处方精简通过逐渐减少或停止用药，尽量减少多药使用，最终改善患者的预后。目的　检索并分析2003—2018年Web of Science收录的关于处方精简的原始研究类文献，探讨文献分布以及研究热点。方法　2018-10-10，在Web of Sciences数据库中采用主题词检索的方式进行检索，检索式如下：主题=（“deprescribing”）OR主题=（“deprescribe”），检索年限选择2003—2018年。首先将所检索文献根据纳入标准进行筛选，然后通过EndNote 8.0及Web of Science网站中的分析检索工具对纳入文献进行文献计量学分析。结果　本研究纳入70篇原始研究类文献。2012—2014年共发表文章2篇（2.9%）；2015年发文量开始增长，全年发表5篇（7.1%）；2016年1月—2018年10月，发文量快速增长〔共计63篇（90.0%）〕。发文量最大的期刊为BMJ Open和European Journal of Hospital Pharmacy Science and Practice（各5篇），其中共有7种SCI期刊发文量≥3篇。BMC Medicine的影响因子（IF）最高（IF=9.08）。高被引（被引量≥7次）的文献有21篇。纳入的文献来自17个国家/地区，其中加拿大、澳大利亚、美国发文量最多。文献平均作者合作度为5.4，即每篇论文平均有5~6位作者；平均机构合作度为3.0，即每篇论文平均有3家机构参与研究。对文献的第一作者职业分布情况进行分析，结果显示大部分为临床药师、公共卫生领域学者和全科医生。纳入文献的研究学科主要是药剂学和内科学，其次是老年医学。结论　处方精简领域的研究虽然尚处于起步阶段，但是已经成为研究热点。2016年以后发文量快速增长，且主要集中在加拿大、澳大利亚、美国等国家。发表文献的第一作者主要为临床药师、公共卫生领域学者和全科医生。

关键词: 文献计量学, 处方精简, Web of Science, 老年人, 多重用药