Research Progress on the Relationship between Depression and Coronary Microvascular Disease

doi:10.12114/j.issn.1007-9572.2019.00.188

Abstract

Abstract: The coronary microvascular system refers to arteries with an inner diameter of less than 0.5 mm，and its number of vessels accounts for 95% of the entire coronary artery tree.The viewpoint that coronary microvascular disease（CMVD）causes angina pectoris in patients has attracted more and more attention.With the continuous development of the bio-psycho-social medical model and the proposal of psycho-cardiology，the adverse effects of psychological disorders on cardiovascular diseases are gradually recognized.This article introduces the definition，epidemiology，pathogenesis and risk factors of CMVD and depression，and summarizes their common pathogenesis and risk factors.It is found that there is a correlation between depression and CMVD，and it is believed that the effective and reasonable treatment of depression can improve the condition of CMVD，and then improve patients' quality of life and prognosis.Therefore，the study of depression and CMVD should be paid more attention by clinicians.

Key words: Depression, Coronary artery disease, Thrombotic microangiopathies, Review, Psychology-cardiology medicine

摘要： 冠状动脉微血管系统指血管内径<0.5 mm的动脉，其血管数量占整个冠状动脉树的95%，冠状动脉微血管疾病（CMVD）引起患者心绞痛症状的观点受到越来越多的关注。随着生物-心理-社会医学模式的不断发展及双心医学的提出，精神心理障碍对心血管疾病的不利影响逐渐得到认可。本文介绍了CMVD和抑郁的定义、流行病学、发病机制及危险因素，总结了CMVD和抑郁共同的发病机制、危险因素。分析发现抑郁与CMVD之间存在相关性，并且认为通过有效、合理地治疗抑郁可以改善CMVD患者病情，进而改善患者生活质量及预后。所以抑郁与CMVD的相关性研究需引起临床医师更多的重视。

关键词: 抑郁, 冠状动脉疾病, 血栓性微血管病, 综述, 双心医学

ZHAO Bo,QIN Gang. Research Progress on the Relationship between Depression and Coronary Microvascular Disease　[J]. Chinese General Practice, 2019, 22(18): 2156-2160. DOI: 10.12114/j.issn.1007-9572.2019.00.188.
赵波,秦纲. 抑郁与冠状动脉微血管疾病相关性研究进展[J]. 中国全科医学, 2019, 22(18): 2156-2160. DOI: 10.12114/j.issn.1007-9572.2019.00.188.

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