Research Progress of Obesity-related Glomerulopathy

doi:10.12114/j.issn.1007-9572.2019.00.011

Abstract

Abstract: The increase of obesity-related glomerulopathy （ORG） parallels to the global epidemic of obesity. And the clinical feature of ORG shows different degrees of proteinuria，with some patients reaching end-stage renal failure. However，the pathogenesis，including hemodynamic abnormalities，renin-angiotensin-aldosterone system activation，insulin resistance，lipid metabolism disorder，adipose factor disorder，inflammation，is not clear. Its treatments include weight loss，blood pressure reduction，metabolic regulation and others. In this article，we reviewed the new progress in pathogenesis and therapies of ORG，including the targeted therapy.

Key words: Obesity-related glomerulopathy, Pathogenesis, Renin-angiotensin system, Insulin resistance, Lipid metabolism disorder, Inflammation, Therapy, Progress

摘要： 随着肥胖的全球流行，肥胖相关性肾病（ORG）发生率明显增高。ORG临床表现为不同程度的蛋白尿，少数患者进展至慢性肾功能不全甚至终末期肾病。ORG的发生与血流动力学异常、肾素-血管紧张素-醛固酮系统激活、胰岛素抵抗、脂代谢紊乱、脂肪细胞因子紊乱、微炎症作用等有关。其治疗方案多样，包括减轻体质量、降压、调节代谢等。本文对ORG的发病机制及治疗新进展，包括靶向治疗做一综述。

ZONG Huimin,WANG Xia,LIU Chunbei. Research Progress of Obesity-related Glomerulopathy　[J]. Chinese General Practice, 2019, 22(17): 2030-2035. DOI: 10.12114/j.issn.1007-9572.2019.00.011.
宗慧敏,王霞,刘春蓓. 肥胖相关性肾病的研究进展[J]. 中国全科医学, 2019, 22(17): 2030-2035. DOI: 10.12114/j.issn.1007-9572.2019.00.011.

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