Abstract: The incidences of gestational diabetes and thyroid disease in pregnancy are increasing，both can lead to adverse pregnancy outcomes，such as abortion，preterm labor，placental abruption，eclampsia and stillbirth.However，the pathogeneses of the two are not clear yet.Studies show that insulin resistance，certain inflammatory factors，adipocytokines and thyroid antibodies are involved.In recent years，the relationship between gestational diabetes and thyroid disease in pregnancy has achieved wide attention.The determination of the associations between the two，between thyroid autoantibodies and increased risk of gestational diabetes，and the investigation of the effects of early interventions on gestational outcome are a vital basis for early prevention and treatment of gestational diabetes and improvement of gestational outcome.We discussed the relationship between gestational diabetes and thyroid disease in pregnancy，aiming to offer a theoretical basis for reducing the adverse gestational outcome by intensifying thyroid function and thyroid autoantibody tests in the first trimester of pregnancy and timely thyroid hormone treatment if hypothyroidism is detected.

Key words: Diabetes, gestational；Thyroid diseases；Insulin；Insulin resistance；Thyroid antibodies

摘要： 妊娠期糖尿病与妊娠期甲状腺疾病的发病率均呈上升趋势，且二者均会引起流产、早产、胎盘早剥、子痫、死胎等不良妊娠结局。二者的发病机制尚未明确，研究发现胰岛素抵抗、某些炎性因子、脂肪细胞因子、甲状腺相关抗体参与其发病。近年来二者的关系备受瞩目，若能明确两者间是否存在关联、甲状腺自身抗体是否与妊娠期糖尿病的风险增加有关、早期干预对妊娠结局的影响等，将会对妊娠期糖尿病的早期防治及改善妊娠结局产生重大意义。本文旨在探讨妊娠期糖尿病与妊娠期甲状腺疾病的关系，从而在妊娠早期加强孕妇甲状腺功能及甲状腺自身抗体的检查，及时给予甲状腺激素补充治疗，减少不良妊娠结局。
糖尿病，妊娠；甲状腺疾病；胰岛素；胰岛素抵抗；甲状腺自身抗体
10.12114/j.issn.1007-9572.2018.00.217

关键词: 糖尿病, 妊娠；甲状腺疾病；胰岛素；胰岛素抵抗；甲状腺自身抗体