Novel Advances in Estrogen Deficiency and Cognitive Impairment in Postmenopausal Women

doi:10.12114/j.issn.1007-9572.2018.00.239

Abstract

Abstract: Estrogen is the main sex hormone in women.Circulating estrogen can maintain female reproduction functions，normal sexual desire and female secondary sexual characteristics，in particular，estrogen in the brain can help maintain the steady state of the central nervous system.Epidemiological data show that the lack of estrogen in postmenopausal women can cause cognitive decline in different degrees，such as impaired concentration，memory impairment and even dementia.We analyzed the effects of estrogen deficiency on the cognitive function in this population from neurobiological mechanism of estrogen affecting cognition，morphological changes of cognitive function regulation center due to estrogen deficiency，correlation between estrogen and cognitive function and estrogen hormone therapy，in order to raise the awareness of cognitive impairment due to estrogen deficiency in elderly postmenopausal women for improving the quality of life of this population and to provide a research direction for clinical workers.

Key words: Estrogens, Cognition disorders, Menopause, Estrogen replacement therapy, Femininity, Review

摘要： 雌激素是女性体内主要的性激素，循环中的雌激素能够维持女性生殖、正常性欲及女性第二性征，大脑中的雌激素能够帮助维持中枢神经系统稳态。流行病学资料显示，绝经后女性雌激素缺乏，会在不同程度上出现认知功能减退，如注意力不集中、记忆力减退甚至痴呆的发生。本文主要从雌激素影响女性认知功能的神经生物学基础、雌激素对认知功能管理中枢形态学的影响、雌激素与女性认知功能相关性以及雌激素替代治疗对认知功能的影响多角度分析雌激素缺乏对认知功能的影响，以期引起人们对绝经后女性认知障碍的关注，从而提高老年女性的生活质量，并为临床工作者提供研究方向。

关键词: 雌激素类, 认知障碍, 绝经期, 雌激素替代疗法, 女性, 综述

YANG Yanyan,ZHAO Lei,YIN Nan, et al. Novel Advances in Estrogen Deficiency and Cognitive Impairment in Postmenopausal Women　[J]. Chinese General Practice, 2018, 21(35): 4299-4304. DOI: 10.12114/j.issn.1007-9572.2018.00.239.
杨艳艳,赵磊,尹楠等. 雌激素缺乏与女性认知障碍关系的研究进展[J]. 中国全科医学, 2018, 21(35): 4299-4304. DOI: 10.12114/j.issn.1007-9572.2018.00.239.

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