Allostatic load (AL) is a multi-systematic physiological indicator to measure chronic stress in the body, reflecting the cumulative physiological burden of chronic stress exposure on the body, which is of great significance for prevention and treatment of chronic diseases. In recent years, studies related to AL are gradually increasing, however, the development of domestic AL related studies is slow. Reviewing the literature related to AL and comprehensively understanding the development trends and hotspots in this field will be beneficial to prompt domestic innovative development of AL research in China.

To understand the research hotspots and frontiers in the field of AL and provide reference for future research by analyzing the relevant literature on AL published in recent years.

Science Citation Index Expanded of Web of Science Core Collection database was searched for literature on the topic of AL from inception to 2022-12-01. Microsoft Excel 2019 and CiteSpace software were applied to perform a visualization analysis of collected articles regarding the publication volume, countries, authors, institutions and keywords.

A total of 509 articles were included, with a slowly increasing trend in annual publication volume. The United States ranked first in annual publication volume (315 articles) and betweenness centrality (0.65) . The top three authors in terms of publication volume were JUSTER of Canada (23 articles) , SEEMAN of the United States (16 articles) and KARLAMANGLA of the United States (12 articles) . The top three institutions in terms of publication volume were the University of California, Los Angeles (39 articles) , the University of Montreal in Canada (21 articles) and the University of Michigan in the United States (20 articles) , respectively. High-frequency keywords included AL, stress, health, socio-economic status, cumulative biological risk. Blood pressure was the keyword with the strongest citation bursts, the strength was 5.8.

The research on AL is gradually becoming a new academic hotspot, which mainly focuses on the influencing factors of AL and its relationship with health outcomes, with rare intervention studies. The domestic development in this field still needs to be further explored. Expanding the scope of research participants, formulating AL measurement methods for different populations and forming norms, as well as performing relevant intervention research should be considered in future studies to promote human health.

非稳态负荷是衡量机体慢性应激的多系统生理指标，反映了慢性应激暴露对身体的累积生理负担，对慢性疾病的防治具有重要意义。近年来非稳态负荷相关研究逐渐增多，但国内相关研究发展较慢。回顾非稳态负荷相关研究文献，全面了解该领域发展趋势及热点，有助于促进我国非稳态负荷研究领域的创新发展。

通过分析近年来发表的非稳态负荷的相关文献，了解该领域的研究热点和前沿，为以后研究提供参考。

在Web of Science核心合集的科学引文索引扩展（SCIE）数据库中检索从建库至2022-12-01以非稳态负荷为主题的文献，应用Microsoft Excel 2019和CiteSpace软件对文献进行发文量、国家、作者、机构和关键词的可视化分析。

共纳入509篇文献，年发文量呈缓慢增长趋势，美国是发文量（315篇）和中介中心性（0.65）均位居第一的国家。发文量排名前3位的作者是加拿大的JUSTER（23篇）、美国的SEEMAN（16篇）和美国的KARLAMANGLA（12篇）。发文量排名前3位的机构分别是位于美国的加利福尼亚大学洛杉矶分校（39篇）、加拿大的蒙特利尔大学（21篇）和美国的密歇根大学（20篇）。高频关键词包括非稳态负荷、应激、健康、社会经济地位、累积生物风险，关键词突现分析中突现程度最高的关键词是血压（突现强度为5.8）。

非稳态负荷的研究正逐渐成为新的学术热点，研究热点主要聚焦于非稳态负荷的影响因素及其与健康结局的关联，干预研究极少。我国在该领域仍需进一步探索，未来研究可考虑扩大研究对象的范围，制定针对不同人群的非稳态负荷测量方法并形成规范以及开展相关干预性研究，促进人类健康。