A Review on the Significance of Elevated 1-hour Post-load Plasma Glucose during the Oral Glucose Tolerance Test

doi:10.12114/j.issn.1007-9572.2022.0311

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (35): 4468-4472.DOI: 10.12114/j.issn.1007-9572.2022.0311

• Review & Perspectives • Previous Articles Next Articles

A Review on the Significance of Elevated 1-hour Post-load Plasma Glucose during the Oral Glucose Tolerance Test

¹Department of General Practice, Peking University First Hospital, Beijing 100034, China
²School of General Practice, Peking University Health Science Center, Beijing 100034, China
³Department of Endocrinology, Peking University First Hospital, Beijing 100034, China

Received:2022-03-13 Revised:2022-05-10 Published:2022-12-15 Online:2022-06-16
Contact: DONG Aimei
About author:
HUANG Y C, DONG A M, HUANG Y Y, et al. A review on the significance of elevated 1-hour post-load plasma glucose during the oral glucose tolerance test[J]. Chinese General Practice, 2022, 25 (35) : 4468-4472.

口服葡萄糖耐量试验中1小时血糖升高的意义研究进展

¹100034　北京市，北京大学第一医院全科医学科
²100034　北京市，北京大学医学部全科医学学系
³100034　北京市，北京大学第一医院内分泌科

通讯作者: 董爱梅
作者简介:
黄雨澄，董爱梅，黄有媛，等.口服葡萄糖耐量试验中1小时血糖升高的意义研究进展[J].中国全科医学，2022，25（35）：4468-4472. [www.chinagp.net] 作者贡献：黄雨澄、董爱梅提出综述撰写思路；黄雨澄负责文献搜索、文献阅读，论文起草、撰写；董爱梅、黄有媛、费秀文负责文章修改；董爱梅负责最终版本修订，对论文负责。
基金资助:
2020年度北京大学临床医学+X青年专项资助项目--探索胰岛β细胞数量及功能在体无创评价方法(PKU2020LCXQ026)

Abstract

Abstract:

Elevated 1-hour post-load plasma glucose (1 hPG) concentration during the oral glucose tolerance test (OGTT) may be associated with insulin resistance and pancreatic β-cell dysfunction, and higher risks of diabetes and cardiovascular disease. We reviewed the studies related to the significance of 1 hPG during the OGTT, in which 1 hPG during the OGTT has been reported to be prevalent in 10% to 40% of people with normal glucose tolerance, and the prevalence is higher in those with impaired glucose tolerance or impaired fasting glucose. Attention should be paid to the cutoff point of 1 hPG during the OGTT for the diagnosis of diabetes and pre-diabetes in Chinese population, which may be beneficial to early diagnosis and intervention of diabetes and pr-diabetes.

Key words: Diabetes mellitus, type 2, Glucose tolerance test, Glucose intolerance, 1-hour post-load plasma glucose, Prediabetic state

摘要：

口服葡萄糖耐量试验（OGTT）1 h血糖升高可能伴随胰岛素抵抗与胰岛β细胞功能障碍，与糖尿病及心血管疾病发生风险有关。本文综述了OGTT 1 h血糖升高的意义，相关研究显示10%~40%的糖耐量正常人群出现1 h血糖升高，在糖耐量受损（IGT）或空腹血糖受损（IFG）人群中比例更高。因此，临床应关注OGTT 1 h血糖，并在中国人群中明确用于糖尿病和糖尿病前期诊断的可能切点，将有助于早期诊断与干预。

关键词: 糖尿病，2型, 葡糖耐量试验, 葡糖耐受不良, 餐后1小时血糖, 糖尿病前期

HUANG Yucheng,DONG Aimei,HUANG Youyuan, et al. A Review on the Significance of Elevated 1-hour Post-load Plasma Glucose during the Oral Glucose Tolerance Test[J]. Chinese General Practice, 2022, 25(35): 4468-4472. DOI: 10.12114/j.issn.1007-9572.2022.0311.
黄雨澄,董爱梅,黄有媛等. 口服葡萄糖耐量试验中1小时血糖升高的意义研究进展[J]. 中国全科医学, 2022, 25(35): 4468-4472. DOI: 10.12114/j.issn.1007-9572.2022.0311.

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A Review on the Significance of Elevated 1-hour Post-load Plasma Glucose during the Oral Glucose Tolerance Test

口服葡萄糖耐量试验中1小时血糖升高的意义研究进展

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