Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression

doi:10.12114/j.issn.1007-9572.2021.02.099

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (12): 1528-1532.DOI: 10.12114/j.issn.1007-9572.2021.02.099

Special Issue: 精神卫生最新文章合辑；神经系统疾病最新文章合辑；脑健康最新研究合辑

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Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression

¹Henan University of Chinese Medicine, Zhengzhou 450046, China
²Rehabilitation Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Received:2021-09-11 Revised:2021-10-24 Published:2021-10-28 Online:2022-03-21
Contact: Xiaodong FENG
About author:
DING Z M, SU K Q, GAO J, et al. Research progress on the relationship between mitochondrial dysfunction and post-stroke depression [J] . Chinese General Practice, 2022, 25 (12) : 1528-1532.

线粒体功能障碍与脑卒中后抑郁的关系研究进展

¹450046　河南省郑州市，河南中医药大学
²450000　河南省郑州市，河南中医药大学第一附属医院康复中心

通讯作者: 冯晓东
作者简介:
丁志敏，苏凯奇，高静，等.线粒体功能障碍与脑卒中后抑郁的关系研究进展[J].中国全科医学，2022，25（12）：1528-1532. [www.chinagp.net] 作者贡献：丁志敏负责论文整体构思与设计，撰写论文初稿；苏凯奇、陈婷玉、冯一璇负责文献检索及整理；高静负责对论文初稿进行修订；冯晓东负责论文最终稿的修订、论文的质量控制及审校，对论文整体负责；所有作者确认了论文的最终稿。
基金资助:
国家自然科学基金面上项目(82174473); 国家自然科学基金青年基金项目(82104973); 国家自然科学联合基金项目(U2004131)

Abstract

Abstract:

Post-stroke depression (PSD) is one of the most common emotional disorders that occurs after cerebrovascular diseases, with core symptoms mainly including low mood, loss of interest, and behavioral inhibition. A large amount of evidence indicates that mitochondrial dysfunction is one of the important pathophysiological factors in the occurrence and development of depression, so we put forward the hypothesis that mitochondrial dysfunction may be one of the pathogeneses of PSD. The article reviewed the relationship between mitochondrial dysfunction and PSD from the aspects of mitochondrial energy metabolism disorder, oxidative stress, deletions, damage or mutation of mitochondrial DNA, and apoptosis, so as to clarify the specific role of mitochondrial dysfunction in the pathogenesis of PSD and provide a new theoretical basis for the development of targeted antidepressants in the future.

Key words: Stroke, Depression, Post-stroke depression, Mitochondrial dysfunction, Oxidative stress, Energy metabolism, Apoptosis

摘要：

脑卒中后抑郁（PSD）是发生于脑血管疾病后常见的一种情绪、情感障碍，核心症状主要表现为心境低落、兴趣消退、行为抑制等。大量证据表明线粒体功能障碍是抑郁症发生、发展的重要病理生理因素之一，遂提出线粒体功能障碍有可能是PSD的发病机制之一这一假说。本文将从线粒体能量代谢障碍、氧化应激、线粒体DNA缺失、损伤或突变、细胞凋亡等方面综述线粒体功能障碍与PSD的关系，为明确线粒体功能障碍在PSD发病过程中的具体作用，为今后开发靶向抗抑郁药物提供新的理论依据。

关键词: 卒中, 抑郁, 脑卒中后抑郁, 线粒体功能障碍, 氧化应激, 能量代谢, 细胞凋亡

Zhimin DING,Kaiqi SU,Jing GAO, et al. Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression[J]. Chinese General Practice, 2022, 25(12): 1528-1532. DOI: 10.12114/j.issn.1007-9572.2021.02.099.
丁志敏,苏凯奇,高静等. 线粒体功能障碍与脑卒中后抑郁的关系研究进展[J]. 中国全科医学, 2022, 25(12): 1528-1532. DOI: 10.12114/j.issn.1007-9572.2021.02.099.

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Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression

线粒体功能障碍与脑卒中后抑郁的关系研究进展

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