Predictive Value of Non-high-density Lipoprotein Cholesterol，Triglyceride-glucose Index，and Ratio of Triglyceride to High-density Lipoprotein Cholesterol in Metabolic Syndrome：a Comparative Study

doi:10.12114/j.issn.1007-9572.2020.00.564

Abstract

Abstract: Background　Anthropometric indices，blood glucose，and blood lipid-related indices have been proposed by relevant studies as simple predictors for metabolic syndrome（MS） used in primary care，but predictive values of these indices are still controversial，and have been studied insufficiently in Chinese population.Objective　To compare the predictive value of non-high-density lipoprotein cholesterol （non-HDL-C），triglyceride-glucose （TyG） index and triglyceride-to-high density lipoprotein cholesterol ratio（TG/HDL-C） in MS and to determine a simple screening indicator for MS.Methods　A total of 9 375 health examinees were selected from Jiangsu Province Geriatric Hospital from April to October 2017.The demographic and anthropometric indices，and biochemical indices including serum glucose and lipids，as well as calculated non-HDL-C，TyG index and TG/HDL-C were obtained and compared by the prevalence of MS identified by the diagnostic criteria recommended by Chinese Diabetes Society，Chinese Medical Association.The receiver operating characteristic （ROC） curve was fit to estimate the predictive value of non-HDL-C，TyG index and TG/HDL-C ratio for MS.Results　Of the participants，1 792（19.1%） had MS and 7 583（80.9%） did not.MS group had higher non-HDL-C，TyG index and TG/HDL-C ratio in comparison with non-MS group （P<0.05）.Non-HDL-C，TyG index and TG/HDL-C ratio elevated linearly with the number increase of metabolic syndrome components （P<0.05）.The AUC of non-HDL-C，TyG index，and TG/HDL-C ratio for predicting MS were 0.623，0.846，and 0.800，respectively，with the optimal threshold corresponding to Youden's index of 3.71 mmol/L，1.53，and 1.27，respectively.Conclusion　The findings of this study suggest that non-HDL-C，TyG index，and TG / HDL-C ratio could be simple screening indicators for MS.

Key words: Metabolic syndrome, Non-high-density lipoprotein cholesterol, Triglyceride-glucose product index, Triglyceride-to-high density lipoprotein cholesterol ratio

摘要： 背景　目前国内外研究中将一些人体测量学指标、血糖、血脂相关指数等作为预测代谢综合征（MS）的简易指标供基层医务人员使用，但结论尚不统一，且在中国人群中相关研究有限。目的　探讨非高密度脂蛋白胆固醇（non-HDL-C）、三酰甘油葡萄糖乘积指数（TyG index）与三酰甘油高密度脂蛋白胆固醇比值（TG/HDL-C）对MS的评估作用，评估其是否可作为筛查MS的简易指标。方法　选取2017年4—10月在江苏省老年病医院健康管理中心体检者9 375例为研究对象，收集其人口学信息、体格检查指标，并进行实验室检查指标测定，计算non-HDL-C、TyG index和TG/HDL-C。根据中华医学会糖尿病学分会建议的诊断标准将研究对象分为MS组和非MS组，比较两组指标的差异。并绘制non-HDL-C、TyG index和TG/HDL-C评估MS的受试者工作特征（ROC）曲线。结果　9 375例研究对象中，MS组1 792例（19.1%），非MS组7 583例（80.9%）。MS组non-HDL-C、TyG index和TG/HDL-C均高于非MS组（P<0.05）。随着MS组分增加，non-HDL-C、TyG index与TG/HDL-C水平均呈上升趋势（P<0.05）。non-HDL-C、TyG index、TG/HDL-C评估MS的ROC曲线下面积（AUC）分别为0.623、0.846、0.800，最佳临界值分别为3.71 mmol/L、1.53、1.27。结论　non-HDL-C、TyG index、TG/HDL-C可作为评估MS风险的简易指标。

关键词: 代谢综合征, 非高密度脂蛋白胆固醇, 三酰甘油葡萄糖乘积指数, 三酰甘油高密度脂蛋白胆固醇比

ZHENG Hui,CHENG Yang,YIN Donghua, et al. Predictive Value of Non-high-density Lipoprotein Cholesterol，Triglyceride-glucose Index，and Ratio of Triglyceride to High-density Lipoprotein Cholesterol in Metabolic Syndrome：a Comparative Study　[J]. Chinese General Practice, 2021, 24(3): 322-326. DOI: 10.12114/j.issn.1007-9572.2020.00.564.
郑卉,程阳,尹冬华等. 非高密度脂蛋白胆固醇和三酰甘油葡萄糖乘积指数及三酰甘油高密度脂蛋白胆固醇比值评估代谢综合征的价值研究[J]. 中国全科医学, 2021, 24(3): 322-326. DOI: 10.12114/j.issn.1007-9572.2020.00.564.

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