Association between Dietary Vitamin C Intake and Knee Osteophytes and Joint Space Narrowing

doi:10.12114/j.issn.1007-9572.2018.00.378

Abstract

Abstract: Background　Previous studies have shown that vitamin C may affect the development of osteoarthritis, but most of the results are not completely consistent.Objective　To examine the influence of dietary vitamin C intake on the prevalence of knee osteophytes（OST） and joint space narrowing（JSN）．Methods　Totals of 5 764 participants who underwent a health checkup at the Health Management Center of Xiangya Hospital，Central South University from October 2013 to November 2014 were included in this study.The basic information of each participant was collected and dietary vitamin C intake was assessed.According to the tertiles of the dietary vitamin C intake level，the participants were divided into three groups：low vitamin C intake group（≤85.65 mg/d，n=1 902），medium vitamin C intake group （85.66-132.08 mg/d，n=1 902） and high vitamin C intake group （≥132.09 mg/d，n=1 960）．Multivariable Logistic regression analysis was used to test the effect of dietary vitamin C intake on knee OST and JSN.Results　The prevalence of knee OST was 16.46%（313/1 902），12.72% （242/1 902），and 12.45%（244/1 960），in low，medium and high vitamin C intake groups，respectively，with a significant difference（P<0.001）．Multivariate Logistic regression analysis showed that vitamin C intake level，age，gender，body mass index （BMI），diabetes，and hypertension were the influencing factors of knee OST （P<0.05）．The prevalence of knee JSN in the low，medium and high vitamin C intake groups was 29.34%（558/1 902），28.65%（545/1 902），28.88%（566/1 960），respectively，with no significant difference（P>0.05）．Multivariate Logistic regression analysis showed that age，gender and BMI were the influencing factors of knee JSN （P<0.05）．Conclusion　The low dietary vitamin C intake may be a risk factor of knee OST，but not knee JSN.

Key words: Ascorbic acid, Vitamins, Knee joint, Osteoarthritis, Osteophyte, Joint space narrowing

摘要： 背景　既往研究表明维生素C可能影响骨关节炎的发生发展，但多数研究结果并不完全一致。目的　探讨膳食维生素C摄入水平对膝关节骨赘及关节间隙狭窄的影响。方法　选取于2013年10月—2014年11月在中南大学湘雅医院健康管理中心进行健康体检者5 764例为研究对象。收集体检者基本资料，并测定其膳食维生素C摄入水平。根据膳食维生素C摄入水平，采用3分位法将体检者分为3组：低维生素C摄入水平组（维生素C摄入水平≤85.65 mg/d，n=1 902）、中维生素C摄入水平组（维生素C摄入水平85.66~132.08 mg/d，n=1 902）、高维生素C摄入水平组（维生素C摄入水平≥132.09 mg/d，n=1 960）。采用多因素Logistic回归探讨膳食维生素C摄入水平对膝关节骨赘及关节间隙狭窄的影响。结果　低、中、高维生素C摄入水平组关节骨赘患病率分别为16.46%（313/1 902）、12.72%（242
/1 902）、12.45%（244/1 960），差异有统计学意义（P<0.001）。多因素Logistic回归分析结果显示，维生素C摄入水平、年龄、性别、体质指数（BMI）、是否合并糖尿病、是否合并高血压是体检者患膝关节骨赘的影响因素（P<0.05）。低、中、高维生素C摄入水平组体检者膝关节间隙狭窄患病率分别为29.34%（558/1 902）、28.65%（545/1 902）、28.88%（566/1 960），差异无统计学意义（P>0.05）。多因素Logistic回归分析结果显示，年龄、性别、BMI是体检者患膝关节间隙狭窄的影响因素（P<0.05）。结论　膳食维生素C摄入水平低可能是患膝关节骨赘的危险因素，但膳食维生素C摄入水平不是膝关节间隙狭窄的影响因素。

关键词: 抗坏血酸, 维生素类, 膝关节, 骨关节炎, 骨赘, 关节间隙狭窄

LI Jiatian,WU Ziying,LI Xiaoxiao, et al. Association between Dietary Vitamin C Intake and Knee Osteophytes and Joint Space Narrowing　[J]. Chinese General Practice, 2019, 22(1): 54-58. DOI: 10.12114/j.issn.1007-9572.2018.00.378.
李嘉添,吴紫莺,李潇骁等. 膳食维生素C摄入水平对膝关节骨赘及关节间隙狭窄的影响研究[J]. 中国全科医学, 2019, 22(1): 54-58. DOI: 10.12114/j.issn.1007-9572.2018.00.378.

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