Abstract: Objective　To explore the clinical features of gastrointestinal malignancies with venous thromboembolism （VTE） as the initial manifestation，so as to improve the diagnosis and treatment of these diseases to enhance the patients' prognosis.Methods　The 42 participants with a definite diagnosis of gastrointestinal malignancies with VTE were enrolled from Yancheng Third People's Hospital from January 2012 to January 2017，including 25 （59.5%） who had VTE after surgery or during the hospitalization （control group） and 17 （40.5%） who sought medical care due to VTE，but were diagnosed with gastrointestinal malignancies after admission and did not receive surgical treatment（study group）．Through reviewing the medical records，we collected their clinical data，including sex，age，BMI，prevalence of underlying diseases，site of VTE，site of cancer，histological type of cancer，degree of cancer invasion，admission laboratory results and so on.Results　Compared with the control group，the proportion of males，the incidence of VTE in both lower limbs and the percent of gastric carcinoma were higher in the study group （P<0.05）．Moreover，the average levels of D-dimer，platelet count and fibrinogen were higher，but the average level of hemoglobin was lower in the study group （P<0.05）．However，both groups showed no significant differences in the distribution of age，BMI，site of VTE （except both lower limbs），tumor histological type and the degree of cancer invasion as well as the incidence of complications（P>0.05）．Conclusion　Gastrointestinal malignancy with VTE as the initial manifestation is more common in males，frequently manifested by DVT in both lower limbs，and gastric cancer is in the majority.Therefore，patients，especially males having VTE in both lower limbs due to unknown reasons，may be considered with gastric cancer possibly.

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关键词: 静脉血栓栓塞, 消化系统肿瘤, 早期表现, 预防