Abstract: We retrospectively analyzed the clinical data from 9 children with Williams-Beuren syndrome who were admitted to the Children's Hospital of Chongqing Medical University from March 2016 to February 2017.The risk factors for pediatric Williams-Beuren syndrome included cold in pregnancy，amniotic fluid abnormalities，MLBW infants，long pregnancy，cesarean section，placentaprevia.All 9 patients had a special appearance，and the growth and development of intelligence andmotor and language abilities were slow.There were 4 cases with dystonia，4 with epilepsy and 3 with hypercalcemia.Seven cases were complicated with congenital heart disease.Two cases had abnormal head magnetic resonance imaging（MRI） findings，and abnormal lumbosacral MRI occurred in 1 case.Moreover，1 case had digestive system abnormality，cranial suture early closure was found in 8 cases，and 6 cases showed abnormal behavior.Therefore，pediatric Williams-Beuren syndrome is associated with multiple risk factors，and patients exhibit diverse clinical features.The disease should be given adequate attention.

Key words: Williams syndrome, Child, Developmental disabilities, Muscle tonus

摘要： 本文选取2016年3月—2017年2月重庆医科大学附属儿童医院收治的9例Williams-Beuren综合征患儿为研究对象，对其临床资料进行回顾性分析，发现儿童Williams-Beuren综合征的高危因素包括母亲孕期感冒、羊水异常、足月小样儿、孕期过长、剖宫产、前置胎盘及宫内发育迟缓。患儿均有特殊面容，且生长、智力、运动及语言均发育迟缓。肌张力异常4例，癫痫4例，高血钙症状3例；合并先天性心脏病7例。颅脑MRI检查结果异常2例，腰骶部MRI检查结果异常1例，消化系统异常1例，颅缝早闭8例，行为异常6例。综上，儿童Williams-Beuren综合征高危因素较多，且患儿临床特点较为多样，应引起重视。

关键词: 威廉斯综合征, 儿童, 发育障碍, 肌张力