Clinical Characteristics and Diagnosis and Treatment Analysis of Monkeypox：from the Perspective of Dermatology

doi:10.12114/j.issn.1007-9572.2024.0466

Chinese General Practice

Department of Dermatology，the First Affiliated Hospitl，Zhejiang University School of Medicine，Hangzhou 31003，China

Received:2024-09-02 Accepted:2024-10-16 Published:2024-11-06 Online:2024-11-06
Contact: ZHU Weifang，Chief physician；E-mail：Wfzhu@163.com

猴痘的临床特征与诊疗分析：基于皮肤科视角

310003 浙江省杭州市，浙江大学医学院附属第一医院皮肤科

通讯作者: 朱伟芳，主任医师；E-mail：Wfzhu@163.com
基金资助:
浙江省基础公益研究项目（LGF21H90004）；国家自然科学青年基金（82103708）

Abstract

Abstract: On July 23，2022 and August 14，2024，the World Health Organization（WHO）declared the daily outbreak of Monkeypox as a Public Health Emergency of International Concern（PHEIC）twice. While gay and bisexual men constituted the majority of cases in 2022，women and children under 15 years old were the primary victims of the 2024 outbreak. This paper examines the etiology，epidemiology，clinical manifestations，diagnosis，comorbidity screening，differential diagnosis，treatment and prevent of monkeypox in light of these two PHEICs. It particularly focuses on elucidating similarities and differences between the two outbreaks. Emphasizing changes in skin rash progression from macules to papules to vesicles to pustules to scabs is introduced for differential diagnosis purposes. The discussion also highlights dermatological perspectives on diagnosing and treating monkeypox with an aim to offer new insights for clinical prevention and treatment.

Key words: Monkeypox, Dermatology, Exanthema, Diagnosis, Treatment

摘要： 2022-07-23和2024-08-14，世界卫生组织两次宣布猴痘（Monkeypox）日疫情构成国际关注的突发公共卫生事件（PHEIC）。2022 年全球暴发的猴痘疫情中，男同性恋和双性恋男性占了绝大多数，但 2024 年疫情主要受累人群是妇女和 15 岁以下儿童及青少年。本文基于两次 PHEIC，从猴痘的病原学、流行病学、临床表现、诊断、共病筛查、皮疹的鉴别诊断、治疗、预防等八个维度进行讨论，重点分析两次疫情的相同及不同点，尤其是针对皮疹变化展开叙述，从斑疹→丘疹→水疱→脓疱→结痂变化过程鉴别诊断，着重于皮肤科视角诊疗猴痘，旨在为临床防治提供新的参考。

关键词: 猴痘, 皮肤病学, 疹, 诊断治疗

CLC Number:

R-332

WU Yanyan,DENG Qiancheng,$authoret .al. Clinical Characteristics and Diagnosis and Treatment Analysis of Monkeypox：from the Perspective of Dermatology[J]. Chinese General Practice. DOI: 10.12114/j.issn.1007-9572.2024.0466.
吴延延,邓前程,罗丽敏,等. 猴痘的临床特征与诊疗分析：基于皮肤科视角[J]. 中国全科医学. DOI: 10.12114/j.issn.1007-9572.2024.0466.

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