Chinese General Practice ›› 2024, Vol. 27 ›› Issue (21): 2572-2577.DOI: 10.12114/j.issn.1007-9572.2023.0769
• Original Research • Previous Articles Next Articles
Received:
2023-09-25
Revised:
2024-02-10
Published:
2024-07-20
Online:
2024-04-18
Contact:
LI Huiqin
通讯作者:
李惠琴
作者简介:
作者贡献:
周潇提出研究思路,设计研究方案,进行统计学分析,起草论文;周云婷、孔小岑、刘晓梅及袁璐负责开展研究,收集数据;荆亭、王蔚萍负责动态血糖监测安装;李惠琴指导研究开展,并进行论文质量控制及修订。
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0769
项目 | 数值 |
---|---|
性别(男/女) | 60/28 |
年龄[M(P25,P75),岁] | 61.0(51.3,67.8) |
病程[M(P25,P75),年] | 5(2,10) |
Hb(g/L) | 146.61±27.19 |
BUN(mmol/L) | 5.19±1.14 |
Scr(μmol/L) | 66.47±13.60 |
ALT(U/L) | 25.14±9.87 |
AST(U/L) | 24.18±8.17 |
Alb(g/L) | 43.90±3.31 |
TP(g/L) | 71.28±4.06 |
UA(μmol/L) | 332.02±81.69 |
TC(mmol/L) | 4.76±1.54 |
TG[M(P25,P75),mmol/L] | 1.66(0.97,2.35) |
HDL(mmol/L) | 1.19±0.27 |
LDL(mmol/L) | 2.56±0.98 |
HbA1c(%) | 6.85±0.97 |
Table 1 Baseline clinical characteristics
项目 | 数值 |
---|---|
性别(男/女) | 60/28 |
年龄[M(P25,P75),岁] | 61.0(51.3,67.8) |
病程[M(P25,P75),年] | 5(2,10) |
Hb(g/L) | 146.61±27.19 |
BUN(mmol/L) | 5.19±1.14 |
Scr(μmol/L) | 66.47±13.60 |
ALT(U/L) | 25.14±9.87 |
AST(U/L) | 24.18±8.17 |
Alb(g/L) | 43.90±3.31 |
TP(g/L) | 71.28±4.06 |
UA(μmol/L) | 332.02±81.69 |
TC(mmol/L) | 4.76±1.54 |
TG[M(P25,P75),mmol/L] | 1.66(0.97,2.35) |
HDL(mmol/L) | 1.19±0.27 |
LDL(mmol/L) | 2.56±0.98 |
HbA1c(%) | 6.85±0.97 |
时间 | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h | 7 h | 8 h | 9 h | 10 h | 11 h | 12 h |
---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天血糖 | 7.41±2.28 | 7.01±2.14 | 6.87±2.00 | 6.84±1.91 | 6.87±1.91 | 7.02±1.90 | 7.42±2.00 | 8.19±2.20 | 9.29±2.31 | 9.79±2.75 | 9.32±2.99 | 8.85±3.23 |
第5天血糖 | 6.94±1.66 | 6.68±1.51 | 6.55±1.46 | 6.48±1.54 | 6.59±1.57 | 6.76±1.60 | 7.02±1.63 | 7.63±1.84 | 8.90±2.43 | 9.19±2.82 | 8.40±2.72 | 7.67±2.40 |
t配对值 | 2.37 | 1.87 | 1.75 | 1.93 | 1.74 | 1.85 | 3.05 | 3.04 | 1.62 | 2.23 | 3.49 | 3.88 |
P值 | 0.020 | 0.065 | 0.084 | 0.057 | 0.086 | 0.068 | 0.003 | 0.003 | 0.110 | 0.028 | 0.001 | <0.001 |
时间 | 13 h | 14 h | 15 h | 16 h | 17 h | 18 h | 19 h | 20 h | 21 h | 22 h | 23 h | 24 h |
第2天血糖 | 8.87±3.17 | 9.52±2.89 | 9.39±2.83 | 8.98±2.76 | 8.63±2.53 | 8.32±2.61 | 8.52±2.57 | 8.96±2.67 | 9.22±3.00 | 8.83±3.03 | 8.33±2.77 | 7.72±2.43 |
第5天血糖 | 7.83±2.33 | 8.66±2.57 | 8.83±2.70 | 8.72±2.78 | 8.36±2.76 | 7.95±2.57 | 7.89±2.37 | 8.37±2.18 | 8.75±2.18 | 8.51±2.31 | 8.12±2.37 | 7.66±2.10 |
t配对值 | 3.72 | 3.11 | 2.00 | 1.02 | 1.11 | 1.49 | 2.94 | 2.72 | 1.73 | 1.20 | 0.85 | 0.28 |
P值 | <0.001 | 0.003 | 0.049 | 0.311 | 0.270 | 0.140 | 0.004 | 0.008 | 0.086 | 0.233 | 0.397 | 0.778 |
Table 2 Comparison of glycemic profile before and after intervention
时间 | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h | 7 h | 8 h | 9 h | 10 h | 11 h | 12 h |
---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天血糖 | 7.41±2.28 | 7.01±2.14 | 6.87±2.00 | 6.84±1.91 | 6.87±1.91 | 7.02±1.90 | 7.42±2.00 | 8.19±2.20 | 9.29±2.31 | 9.79±2.75 | 9.32±2.99 | 8.85±3.23 |
第5天血糖 | 6.94±1.66 | 6.68±1.51 | 6.55±1.46 | 6.48±1.54 | 6.59±1.57 | 6.76±1.60 | 7.02±1.63 | 7.63±1.84 | 8.90±2.43 | 9.19±2.82 | 8.40±2.72 | 7.67±2.40 |
t配对值 | 2.37 | 1.87 | 1.75 | 1.93 | 1.74 | 1.85 | 3.05 | 3.04 | 1.62 | 2.23 | 3.49 | 3.88 |
P值 | 0.020 | 0.065 | 0.084 | 0.057 | 0.086 | 0.068 | 0.003 | 0.003 | 0.110 | 0.028 | 0.001 | <0.001 |
时间 | 13 h | 14 h | 15 h | 16 h | 17 h | 18 h | 19 h | 20 h | 21 h | 22 h | 23 h | 24 h |
第2天血糖 | 8.87±3.17 | 9.52±2.89 | 9.39±2.83 | 8.98±2.76 | 8.63±2.53 | 8.32±2.61 | 8.52±2.57 | 8.96±2.67 | 9.22±3.00 | 8.83±3.03 | 8.33±2.77 | 7.72±2.43 |
第5天血糖 | 7.83±2.33 | 8.66±2.57 | 8.83±2.70 | 8.72±2.78 | 8.36±2.76 | 7.95±2.57 | 7.89±2.37 | 8.37±2.18 | 8.75±2.18 | 8.51±2.31 | 8.12±2.37 | 7.66±2.10 |
t配对值 | 3.72 | 3.11 | 2.00 | 1.02 | 1.11 | 1.49 | 2.94 | 2.72 | 1.73 | 1.20 | 0.85 | 0.28 |
P值 | <0.001 | 0.003 | 0.049 | 0.311 | 0.270 | 0.140 | 0.004 | 0.008 | 0.086 | 0.233 | 0.397 | 0.778 |
项目 | MBG(mmol/L) | SD(mmol/L) | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] |
---|---|---|---|---|---|---|
第2天 | 8.34±1.97 | 1.80±0.80 | 4.53±2.25 | 78.21±24.64 | 9.90(3.82,31.86) | 0(0,0) |
第5天 | 7.85±1.65 | 1.62±0.74 | 3.80±1.80 | 84.28±21.87 | 5.38 (0,22.83) | 0(0,0) |
t配对(Z配对)值 | 4.07 | 2.79 | 3.24 | 3.41 | -3.83a | -0.73a |
P值 | <0.001 | 0.006 | 0.002 | 0.001 | <0.001 | 0.463 |
Table 3 Comparison of CGM parameters before and after intervention
项目 | MBG(mmol/L) | SD(mmol/L) | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] |
---|---|---|---|---|---|---|
第2天 | 8.34±1.97 | 1.80±0.80 | 4.53±2.25 | 78.21±24.64 | 9.90(3.82,31.86) | 0(0,0) |
第5天 | 7.85±1.65 | 1.62±0.74 | 3.80±1.80 | 84.28±21.87 | 5.38 (0,22.83) | 0(0,0) |
t配对(Z配对)值 | 4.07 | 2.79 | 3.24 | 3.41 | -3.83a | -0.73a |
P值 | <0.001 | 0.006 | 0.002 | 0.001 | <0.001 | 0.463 |
时间 | 早餐前1 h | 早餐后2 h | 午餐前1 h | 午餐后2 h | 晚餐前1 h | 晚餐后2 h |
---|---|---|---|---|---|---|
第2天 | 7.42±2.00 | 8.74±2.13 | 9.32±2.99 | 8.86±3.10 | 8.63±2.53 | 8.74±2.50 |
第5天 | 7.02±1.63 | 8.27±2.01 | 8.40±2.72 | 7.75±2.24 | 8.36±2.76 | 7.92±2.37 |
t配对值 | 3.05 | 2.44 | 3.49 | 4.02 | 1.11 | 3.86 |
P值 | 0.003 | 0.017 | 0.001 | <0.001 | 0.270 | <0.001 |
Table 4 Comparison of blood glucose levels before and after intervention
时间 | 早餐前1 h | 早餐后2 h | 午餐前1 h | 午餐后2 h | 晚餐前1 h | 晚餐后2 h |
---|---|---|---|---|---|---|
第2天 | 7.42±2.00 | 8.74±2.13 | 9.32±2.99 | 8.86±3.10 | 8.63±2.53 | 8.74±2.50 |
第5天 | 7.02±1.63 | 8.27±2.01 | 8.40±2.72 | 7.75±2.24 | 8.36±2.76 | 7.92±2.37 |
t配对值 | 3.05 | 2.44 | 3.49 | 4.02 | 1.11 | 3.86 |
P值 | 0.003 | 0.017 | 0.001 | <0.001 | 0.270 | <0.001 |
组别 | 例数 | MBG(mmol/L) | SD | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | ||
病程<10年组 | 62 | 8.27±2.11 | 7.82±1.89a | 1.78±0.81 | 1.58±0.77a | 4.47±2.01 | 3.75±1.79a | 77.88±25.71 | 83.81±24.69a | 9.38(2.26,37.07) | 4.69(0,14.67) a | 0(0,0) | 0(0,0) |
病程≥10年组 | 26 | 8.51±1.60 | 7.95±0.90a | 1.84±0.79 | 1.72±0.66 | 4.67±2.79 | 3.92±1.83 | 78.99±22.35 | 85.38±13.26 | 14.76(5.99,29.25) | 12.50(0,23.87) | 0(0,0) | 0(0,0) |
t(Z)值 | -0.53 | -0.44 | -0.32 | -0.83 | -0.37 | -0.41 | -0.19 | -0.39 | 0.07b | 0.44b | 1.63b | -0.54b | |
P值 | 0.600 | 0.662 | 0.751 | 0.408 | 0.711 | 0.685 | 0.849 | 0.699 | 0.944 | 0.658 | 0.108 | 0.592 |
Table 5 Comparison of CGM parameters before and after treatment in diabetes of different course groups
组别 | 例数 | MBG(mmol/L) | SD | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | ||
病程<10年组 | 62 | 8.27±2.11 | 7.82±1.89a | 1.78±0.81 | 1.58±0.77a | 4.47±2.01 | 3.75±1.79a | 77.88±25.71 | 83.81±24.69a | 9.38(2.26,37.07) | 4.69(0,14.67) a | 0(0,0) | 0(0,0) |
病程≥10年组 | 26 | 8.51±1.60 | 7.95±0.90a | 1.84±0.79 | 1.72±0.66 | 4.67±2.79 | 3.92±1.83 | 78.99±22.35 | 85.38±13.26 | 14.76(5.99,29.25) | 12.50(0,23.87) | 0(0,0) | 0(0,0) |
t(Z)值 | -0.53 | -0.44 | -0.32 | -0.83 | -0.37 | -0.41 | -0.19 | -0.39 | 0.07b | 0.44b | 1.63b | -0.54b | |
P值 | 0.600 | 0.662 | 0.751 | 0.408 | 0.711 | 0.685 | 0.849 | 0.699 | 0.944 | 0.658 | 0.108 | 0.592 |
组别 | 例数 | MBG(mmol/L) | SD | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | ||
年龄<65岁组 | 55 | 8.42±2.10 | 7.94±1.87a | 1.78±0.82 | 1.55±0.62a | 4.54±2.22 | 3.78±1.87a | 77.40±26.92 | 83.06±24.56a | 9.38(2.43,38.89) | 5.56(0,22.92)a | 0(0,0) | 0(0,0) |
年龄<65岁组 | 33 | 8.20±1.76 | 7.72±1.21a | 1.83±0.78 | 1.74±0.90 | 4.52±2.34 | 3.85±1.70 | 79.57±20.60 | 86.30±16.62a | 10.76(5.56,30.90) | 5.21(0,24.65)a | 0(0,0) | 0(0,0) |
t(Z)值 | 0.51 | 0.60 | -0.27 | -1.21 | 0.05 | -0.17 | -0.40 | -0.67 | 0.55b | 0.64b | -1.30b | 0.10b | |
P值 | 0.615 | 0.548 | 0.788 | 0.231 | 0.961 | 0.866 | 0.692 | 0.504 | 0.587 | 0.526 | 0.204 | 0.919 |
Table 6 Comparison of CGM parameters before and after treatment in patients of different age groups
组别 | 例数 | MBG(mmol/L) | SD | MAGE(mmol/L) | TIR(%) | TAR[M(P25,P75),%] | TBR[M(P25,P75),%] | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | 第2天 | 第5天 | ||
年龄<65岁组 | 55 | 8.42±2.10 | 7.94±1.87a | 1.78±0.82 | 1.55±0.62a | 4.54±2.22 | 3.78±1.87a | 77.40±26.92 | 83.06±24.56a | 9.38(2.43,38.89) | 5.56(0,22.92)a | 0(0,0) | 0(0,0) |
年龄<65岁组 | 33 | 8.20±1.76 | 7.72±1.21a | 1.83±0.78 | 1.74±0.90 | 4.52±2.34 | 3.85±1.70 | 79.57±20.60 | 86.30±16.62a | 10.76(5.56,30.90) | 5.21(0,24.65)a | 0(0,0) | 0(0,0) |
t(Z)值 | 0.51 | 0.60 | -0.27 | -1.21 | 0.05 | -0.17 | -0.40 | -0.67 | 0.55b | 0.64b | -1.30b | 0.10b | |
P值 | 0.615 | 0.548 | 0.788 | 0.231 | 0.961 | 0.866 | 0.692 | 0.504 | 0.587 | 0.526 | 0.204 | 0.919 |
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