Chinese General Practice ›› 2022, Vol. 25 ›› Issue (31): 3857-3865.DOI: 10.12114/j.issn.1007-9572.2022.0437
Special Issue: 神经退行性病变最新文章合集; 阿尔茨海默病最新文章合集
• Article·Focus on Cognitive Impairment • Previous Articles Next Articles
Received:
2022-06-22
Revised:
2022-08-06
Published:
2022-11-05
Online:
2022-09-19
Contact:
XIE Haiqun
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谢海群
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0437
组别 | 例数 | 年龄〔M(QR),岁〕 | 性别(男/女) | 身高( | 体质量( | 鞋码〔M(QR),码〕 | MMSE量表评分〔M(QR),分〕 | MoCA量表评分〔M(QR),分〕 |
---|---|---|---|---|---|---|---|---|
HC组 | 33 | 67.0(5.5) | 14/19 | 160.24±6.82 | 58.65±9.46 | 38.00(3.00) | 27(2) | 24.0(3.5) |
aMCI组 | 55 | 68.0(5.0) | 27/28 | 161.40±6.96 | 60.92±8.92 | 39.00(3.00) | 25(3) | 20.0(4.0) |
AD组 | 10 | 66.0(11.0) | 3/7 | 159.35±8.21 | 60.00±9.67 | 38.00(4.25) | 21(3) | 14.0(5.2) |
检验统计量值 | 1.390a | 1.370b | 0.515c | 0.629c | 2.743a | 33.247a | 48.238a | |
P值 | 0.499 | 0.504 | 0.599 | 0.535 | 0.254 | <0.001 | <0.001 |
Table 1 Comparison of basic information of three groups of subjects
组别 | 例数 | 年龄〔M(QR),岁〕 | 性别(男/女) | 身高( | 体质量( | 鞋码〔M(QR),码〕 | MMSE量表评分〔M(QR),分〕 | MoCA量表评分〔M(QR),分〕 |
---|---|---|---|---|---|---|---|---|
HC组 | 33 | 67.0(5.5) | 14/19 | 160.24±6.82 | 58.65±9.46 | 38.00(3.00) | 27(2) | 24.0(3.5) |
aMCI组 | 55 | 68.0(5.0) | 27/28 | 161.40±6.96 | 60.92±8.92 | 39.00(3.00) | 25(3) | 20.0(4.0) |
AD组 | 10 | 66.0(11.0) | 3/7 | 159.35±8.21 | 60.00±9.67 | 38.00(4.25) | 21(3) | 14.0(5.2) |
检验统计量值 | 1.390a | 1.370b | 0.515c | 0.629c | 2.743a | 33.247a | 48.238a | |
P值 | 0.499 | 0.504 | 0.599 | 0.535 | 0.254 | <0.001 | <0.001 |
组别 | 例数 | 步幅( | 步速( | 步频( | 支撑相〔M(QR),%〕 | 摆动相〔M(QR),%〕 | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.16±0.13 | 0.92±0.14 | 96.19±10.40 | 65.70(3.80) | 34.30(3.80) | 1.26±0.16 | 0.83±0.13 | 0.43±0.04 | 42.62±3.96 | 31.70(6.70) |
aMCI组 | 55 | 1.08±0.16b | 0.87±0.14 | 96.10±10.18 | 66.30(2.60) | 33.70(2.60) | 1.27±0.15 | 0.84±0.12 | 0.44±0.04 | 41.05±4.48 | 28.90(5.90)b |
AD组 | 10 | 1.00±0.17b | 0.75±0.17bc | 89.69±9.35 | 67.55(5.95) | 32.45(5.95) | 1.37±0.17 | 0.93±0.16 | 0.44±0.03 | 38.34±5.20b | 28.05(8.47)b |
F(H)值 | 5.265 | 4.927 | 1.800 | 2.633a | 2.633a | 2.053 | 2.719 | 0.112 | 3.872 | 12.323a | |
P值 | 0.007 | 0.009 | 0.171 | 0.236 | 0.236 | 0.134 | 0.071 | 0.894 | 0.024 | 0.002 |
Table 2 Comparison of gait parameters of three groups of subjects during the free walking test
组别 | 例数 | 步幅( | 步速( | 步频( | 支撑相〔M(QR),%〕 | 摆动相〔M(QR),%〕 | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.16±0.13 | 0.92±0.14 | 96.19±10.40 | 65.70(3.80) | 34.30(3.80) | 1.26±0.16 | 0.83±0.13 | 0.43±0.04 | 42.62±3.96 | 31.70(6.70) |
aMCI组 | 55 | 1.08±0.16b | 0.87±0.14 | 96.10±10.18 | 66.30(2.60) | 33.70(2.60) | 1.27±0.15 | 0.84±0.12 | 0.44±0.04 | 41.05±4.48 | 28.90(5.90)b |
AD组 | 10 | 1.00±0.17b | 0.75±0.17bc | 89.69±9.35 | 67.55(5.95) | 32.45(5.95) | 1.37±0.17 | 0.93±0.16 | 0.44±0.03 | 38.34±5.20b | 28.05(8.47)b |
F(H)值 | 5.265 | 4.927 | 1.800 | 2.633a | 2.633a | 2.053 | 2.719 | 0.112 | 3.872 | 12.323a | |
P值 | 0.007 | 0.009 | 0.171 | 0.236 | 0.236 | 0.134 | 0.071 | 0.894 | 0.024 | 0.002 |
组别 | 例数 | 步幅( | 步速〔M(QR),m/s 〕 | 步频( | 支撑相( | 摆动相( | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.07±0.14 | 0.77(0.14) | 87.58±8.39 | 67.11±1.66 | 32.89±1.66 | 1.39±0.15 | 0.94±0.12 | 0.46±0.04 | 40.13±3.93 | 29.40(4.90) |
aMCI组 | 55 | 1.01±0.16 | 0.72(0.21)b | 85.23±15.34 | 68.11±2.62 | 31.89±2.62 | 1.48±0.31 | 1.01±0.25 | 0.47±0.07 | 36.92±4.53b | 26.10(7.10)b |
AD组 | 10 | 0.96±0.23 | 0.54(0.25)b | 77.75±16.43 | 68.94±4.00 | 31.06±4.00 | 1.61±0.32 | 1.11±0.22b | 0.50±0.13 | 33.39±6.10bc | 24.40(10.65)b |
F(H)值 | 2.167 | 10.069a | 2.026 | 2.654 | 2.654 | 2.788 | 3.126 | 1.426 | 10.158 | 9.024a | |
P值 | 0.120 | 0.007 | 0.138 | 0.076 | 0.076 | 0.067 | 0.048 | 0.245 | <0.001 | 0.011 |
Table 3 Comparison of gait parameters of three groups of subjects during performing the dual-task of counting backwards in sevens
组别 | 例数 | 步幅( | 步速〔M(QR),m/s 〕 | 步频( | 支撑相( | 摆动相( | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.07±0.14 | 0.77(0.14) | 87.58±8.39 | 67.11±1.66 | 32.89±1.66 | 1.39±0.15 | 0.94±0.12 | 0.46±0.04 | 40.13±3.93 | 29.40(4.90) |
aMCI组 | 55 | 1.01±0.16 | 0.72(0.21)b | 85.23±15.34 | 68.11±2.62 | 31.89±2.62 | 1.48±0.31 | 1.01±0.25 | 0.47±0.07 | 36.92±4.53b | 26.10(7.10)b |
AD组 | 10 | 0.96±0.23 | 0.54(0.25)b | 77.75±16.43 | 68.94±4.00 | 31.06±4.00 | 1.61±0.32 | 1.11±0.22b | 0.50±0.13 | 33.39±6.10bc | 24.40(10.65)b |
F(H)值 | 2.167 | 10.069a | 2.026 | 2.654 | 2.654 | 2.788 | 3.126 | 1.426 | 10.158 | 9.024a | |
P值 | 0.120 | 0.007 | 0.138 | 0.076 | 0.076 | 0.067 | 0.048 | 0.245 | <0.001 | 0.011 |
组别 | 例数 | 步幅( | 步速( | 步频( | 支撑相〔M(QR),%〕 | 摆动相〔M(QR),%〕 | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.09±0.16 | 0.77±0.11 | 84.97±12.39 | 67.90(3.95) | 32.10(3.95) | 1.46±0.25 | 1.00±0.20 | 0.47±0.06 | 39.94±4.26 | 29.30(4.15) |
aMCI组 | 55 | 1.03±0.16 | 0.72±0.14 | 83.31±14.40 | 68.00(3.40) | 32.00(3.40) | 1.50±0.28 | 1.02±0.22 | 0.47±0.07 | 38.07±4.27 | 27.10(5.40)b |
AD组 | 10 | 0.96±0.19b | 0.62±0.14bc | 79.54±12.04 | 70.80(5.15) | 29.20(5.15) | 1.59±0.26 | 1.12±0.22 | 0.48±0.05 | 34.27±5.57bc | 23.05(7.15)bc |
F(H)值 | 3.230 | 4.759 | 0.629 | 4.080a | 4.080a | 0.861 | 1.165 | 0.160 | 6.531 | 13.584a | |
P值 | 0.044 | 0.011 | 0.535 | 0.130 | 0.130 | 0.426 | 0.316 | 0.852 | 0.002 | 0.001 |
Table 4 Comparison of gait parameters of three groups of subjects during performing the dual-task of counting backwards from 100
组别 | 例数 | 步幅( | 步速( | 步频( | 支撑相〔M(QR),%〕 | 摆动相〔M(QR),%〕 | 跨步时间( | 支撑时间( | 摆动时间( | 足趾离地角度( | 足跟着地角度〔M(QR),°〕 |
---|---|---|---|---|---|---|---|---|---|---|---|
HC组 | 33 | 1.09±0.16 | 0.77±0.11 | 84.97±12.39 | 67.90(3.95) | 32.10(3.95) | 1.46±0.25 | 1.00±0.20 | 0.47±0.06 | 39.94±4.26 | 29.30(4.15) |
aMCI组 | 55 | 1.03±0.16 | 0.72±0.14 | 83.31±14.40 | 68.00(3.40) | 32.00(3.40) | 1.50±0.28 | 1.02±0.22 | 0.47±0.07 | 38.07±4.27 | 27.10(5.40)b |
AD组 | 10 | 0.96±0.19b | 0.62±0.14bc | 79.54±12.04 | 70.80(5.15) | 29.20(5.15) | 1.59±0.26 | 1.12±0.22 | 0.48±0.05 | 34.27±5.57bc | 23.05(7.15)bc |
F(H)值 | 3.230 | 4.759 | 0.629 | 4.080a | 4.080a | 0.861 | 1.165 | 0.160 | 6.531 | 13.584a | |
P值 | 0.044 | 0.011 | 0.535 | 0.130 | 0.130 | 0.426 | 0.316 | 0.852 | 0.002 | 0.001 |
项目 | RF | GBDT | |||
---|---|---|---|---|---|
准确度 | AUC | 准确度 | AUC | ||
自由行走 | |||||
HC组/aMCI组 | 0.623 5 | 0.608 3 | 0.636 6 | 0.576 5 | |
HC组/AD组 | 0.811 1 | 0.888 9 | 0.816 7 | 0.888 9 | |
aMCI组/AD组 | 0.861 5 | 0.833 3 | 0.815 4 | 0.785 7 | |
倍数7测试 | |||||
HC组/aMCI组 | 0.647 7 | 0.628 6 | 0.637 3 | 0.606 8 | |
HC组/AD组 | 0.838 9 | 0.916 7 | 0.836 1 | 0.875 0 | |
aMCI组/AD组 | 0.830 8 | 0.812 5 | 0.769 2 | 0.809 5 | |
倒数100测试 | |||||
HC组/aMCI组 | 0.683 7 | 0.695 8 | 0.717 0 | 0.742 9 | |
HC组/AD组 | 0.838 9 | 0.900 0 | 0.741 7 | 0.777 8 | |
aMCI组/AD组 | 0.800 0 | 0.850 0 | 0.753 8 | 0.800 0 |
Table 5 The accuracy and AUC value of RF model and GBDT model in distinguishing healthycontrols,amnestic mild cognitive impairment and Alzheimer's disease patientsbased on 10 gait features
项目 | RF | GBDT | |||
---|---|---|---|---|---|
准确度 | AUC | 准确度 | AUC | ||
自由行走 | |||||
HC组/aMCI组 | 0.623 5 | 0.608 3 | 0.636 6 | 0.576 5 | |
HC组/AD组 | 0.811 1 | 0.888 9 | 0.816 7 | 0.888 9 | |
aMCI组/AD组 | 0.861 5 | 0.833 3 | 0.815 4 | 0.785 7 | |
倍数7测试 | |||||
HC组/aMCI组 | 0.647 7 | 0.628 6 | 0.637 3 | 0.606 8 | |
HC组/AD组 | 0.838 9 | 0.916 7 | 0.836 1 | 0.875 0 | |
aMCI组/AD组 | 0.830 8 | 0.812 5 | 0.769 2 | 0.809 5 | |
倒数100测试 | |||||
HC组/aMCI组 | 0.683 7 | 0.695 8 | 0.717 0 | 0.742 9 | |
HC组/AD组 | 0.838 9 | 0.900 0 | 0.741 7 | 0.777 8 | |
aMCI组/AD组 | 0.800 0 | 0.850 0 | 0.753 8 | 0.800 0 |
Figure 1 The importance of gait characteristics during performingdifferent walking tests in identifying healthycontrols and Alzheimer's disease patients
Figure 2 The importance of gait characteristics during performing different walking tests in identifying amnestic mild cognitive impairment and Alzheimer's disease patients
项目 | RF | GBDT | |||
---|---|---|---|---|---|
准确率 | AUC | 准确率 | AUC | ||
自由行走 | |||||
HC组/AD组 | 0.858 3 | 0.900 0 | 0.811 1 | 0.791 7 | |
aMCI组/AD组 | 0.876 9 | 0.933 3 | 0.846 1 | 0.812 5 | |
倍数7测试 | |||||
HC组/AD组 | 0.905 6 | 0.944 4 | 0.905 6 | 0.944 4 | |
aMCI组/AD组 | 0.876 9 | 0.817 3 | 0.830 8 | 0.866 7 | |
倒数100测试 | |||||
HC组/AD组 | 0.858 3 | 0.875 0 | 0.819 4 | 0.833 3 | |
aMCI组/AD组 | 0.846 2 | 0.866 7 | 0.769 2 | 0.781 3 |
Table 6 The accuracy and AUC value of RF model and GBDT model in distinguishing healthy controls,amnestic mild cognitive impairment and Alzheimer's disease patients based on important gait features
项目 | RF | GBDT | |||
---|---|---|---|---|---|
准确率 | AUC | 准确率 | AUC | ||
自由行走 | |||||
HC组/AD组 | 0.858 3 | 0.900 0 | 0.811 1 | 0.791 7 | |
aMCI组/AD组 | 0.876 9 | 0.933 3 | 0.846 1 | 0.812 5 | |
倍数7测试 | |||||
HC组/AD组 | 0.905 6 | 0.944 4 | 0.905 6 | 0.944 4 | |
aMCI组/AD组 | 0.876 9 | 0.817 3 | 0.830 8 | 0.866 7 | |
倒数100测试 | |||||
HC组/AD组 | 0.858 3 | 0.875 0 | 0.819 4 | 0.833 3 | |
aMCI组/AD组 | 0.846 2 | 0.866 7 | 0.769 2 | 0.781 3 |
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