Chinese General Practice ›› 2022, Vol. 25 ›› Issue (25): 3107-3113.DOI: 10.12114/j.issn.1007-9572.2022.0109
Special Issue: 神经退行性病变最新文章合集; 阿尔茨海默病最新文章合集; 衰弱最新文章合集
• Original Research·Geriatric Problems • Previous Articles Next Articles
Received:
2022-03-02
Revised:
2022-06-20
Published:
2022-09-05
Online:
2022-07-21
Contact:
Lina WANG
About author:
通讯作者:
王丽娜
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0109
衰弱 | 例数 | 性别〔n(%)〕 | 年龄〔n(%)〕 | 受教育程度〔n(%)〕 | 婚姻状况〔n(%)〕 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
男 | 女 | 60~69岁 | 70~79岁 | ≥80岁 | 文盲 | 小学/初中 | 高中/中专 | 大专及以上 | 已婚 | 离异/丧偶 | |||
否 | 94 | 40(42.6) | 54(57.4) | 53(56.4) | 35(37.2) | 6(6.4) | 29(30.9) | 43(45.7) | 17(18.1) | 5(5.3) | 85(90.4) | 9(9.6) | |
是 | 136 | 64(47.1) | 72(52.9) | 47(34.6) | 51(37.5) | 38(27.9) | 46(33.8) | 58(42.6) | 25(18.4) | 7(5.1) | 100(73.5) | 36(26.5) | |
χ2(Z)值 | 0.456 | 19.593 | 0.278 | 10.083 | |||||||||
P值 | 0.500 | <0.001 | 0.964 | 0.001 | |||||||||
衰弱 | 居住情况〔n(%)〕 | 经济来源〔n(%)〕 | 吸烟〔n( %)〕 | 饮酒〔n( %)〕 | BMI〔M(QR),kg/m2〕 | 握力〔M(QR),kg〕 | |||||||
独居 | 与家人居住 | 与其他照顾者居住 | 退休金 | 个人储蓄 | 家人给予 | 抚恤金 | |||||||
否 | 9(9.6) | 84(89.4) | 1(1.1) | 41(43.6) | 50(53.2) | 2(2.1) | 1(1.1) | 15(16.0) | 15(16.0) | 23.59(3.84) | 20.12(6.42) | ||
是 | 12(8.8) | 114(83.8) | 10(7.4) | 69(50.7) | 47(34.6) | 13(9.6) | 7(5.1) | 10(7.4) | 14(10.3) | 22.69(4.42) | 16.22(9.05) | ||
χ2(Z)值 | 4.829 | 12.535 | 4.248 | 1.618 | -1.479a | -4.191a | |||||||
P值 | 0.089 | 0.006 | 0.039 | 0.203 | 0.139 | <0.001 | |||||||
衰弱 | SPPB评估结果〔n(%)〕 | CCI〔M(QR)〕 | 视力状况〔n(%)〕 | 听力状况〔n(%)〕 | |||||||||
良好 | 中等 | 差 | 无损伤 | 轻度损伤 | 中度损伤 | 重度损伤 | 无困难 | 有些困难 | 极度困难 | ||||
否 | 49(52.1) | 37(39.4) | 8(8.5) | 3(2) | 41(43.6) | 48(51.1) | 4(4.3) | 1(1.1) | 81(86.2) | 11(11.7) | 2(2.1) | ||
是 | 27(19.9) | 49(36.0) | 60(44.1) | 5(3) | 41(30.1) | 77(56.6) | 15(11.0) | 3(2.2) | 89(65.4) | 34(25.0) | 13(9.6) | ||
χ2(Z)值 | 41.523 | -7.525a | 6.649 | 12.961 | |||||||||
P值 | <0.001 | <0.001 | 0.084 | 0.002 | |||||||||
衰弱 | 咀嚼功能〔n(%)〕 | MoCA-B得分〔M(QR),分〕 | BI〔M(QR)〕 | PIM〔n( %)〕 | PIM涉及药物数量〔n(%)〕 | 神经系统类PIM〔n( %)〕 | 心血管系统类PIM〔n( %)〕 | 血液系统类PIM〔n( %)〕 | 泌尿系统类PIM〔n( %)〕 | ||||
无困难 | 有些困难 | 极度困难 | 0种 | 1种 | ≥2种 | ||||||||
否 | 71(75.5) | 16(17.0) | 7(7.4) | 15(5) | 100(0) | 26(27.7) | 68(72.3) | 20(21.3) | 6(6.4) | 2(2.1) | 11(11.7) | 14(14.9) | 4(4.3) |
是 | 59(43.4) | 44(32.4) | 33(24.3) | 14(6) | 95(15) | 110(80.9) | 26(19.1) | 43(31.6) | 67(49.3) | 29(21.3) | 54(39.7) | 59(43.4) | 27(19.9) |
χ2(Z)值 | 24.212 | -3.216a | -8.480a | 62.780 | 72.897 | 17.563 | 21.500 | 20.822 | 11.596 | ||||
P值 | <0.001 | 0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.001 |
Table 1 Comparison of general data and PIM between frail and non-frail older adults with MCI in the community
衰弱 | 例数 | 性别〔n(%)〕 | 年龄〔n(%)〕 | 受教育程度〔n(%)〕 | 婚姻状况〔n(%)〕 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
男 | 女 | 60~69岁 | 70~79岁 | ≥80岁 | 文盲 | 小学/初中 | 高中/中专 | 大专及以上 | 已婚 | 离异/丧偶 | |||
否 | 94 | 40(42.6) | 54(57.4) | 53(56.4) | 35(37.2) | 6(6.4) | 29(30.9) | 43(45.7) | 17(18.1) | 5(5.3) | 85(90.4) | 9(9.6) | |
是 | 136 | 64(47.1) | 72(52.9) | 47(34.6) | 51(37.5) | 38(27.9) | 46(33.8) | 58(42.6) | 25(18.4) | 7(5.1) | 100(73.5) | 36(26.5) | |
χ2(Z)值 | 0.456 | 19.593 | 0.278 | 10.083 | |||||||||
P值 | 0.500 | <0.001 | 0.964 | 0.001 | |||||||||
衰弱 | 居住情况〔n(%)〕 | 经济来源〔n(%)〕 | 吸烟〔n( %)〕 | 饮酒〔n( %)〕 | BMI〔M(QR),kg/m2〕 | 握力〔M(QR),kg〕 | |||||||
独居 | 与家人居住 | 与其他照顾者居住 | 退休金 | 个人储蓄 | 家人给予 | 抚恤金 | |||||||
否 | 9(9.6) | 84(89.4) | 1(1.1) | 41(43.6) | 50(53.2) | 2(2.1) | 1(1.1) | 15(16.0) | 15(16.0) | 23.59(3.84) | 20.12(6.42) | ||
是 | 12(8.8) | 114(83.8) | 10(7.4) | 69(50.7) | 47(34.6) | 13(9.6) | 7(5.1) | 10(7.4) | 14(10.3) | 22.69(4.42) | 16.22(9.05) | ||
χ2(Z)值 | 4.829 | 12.535 | 4.248 | 1.618 | -1.479a | -4.191a | |||||||
P值 | 0.089 | 0.006 | 0.039 | 0.203 | 0.139 | <0.001 | |||||||
衰弱 | SPPB评估结果〔n(%)〕 | CCI〔M(QR)〕 | 视力状况〔n(%)〕 | 听力状况〔n(%)〕 | |||||||||
良好 | 中等 | 差 | 无损伤 | 轻度损伤 | 中度损伤 | 重度损伤 | 无困难 | 有些困难 | 极度困难 | ||||
否 | 49(52.1) | 37(39.4) | 8(8.5) | 3(2) | 41(43.6) | 48(51.1) | 4(4.3) | 1(1.1) | 81(86.2) | 11(11.7) | 2(2.1) | ||
是 | 27(19.9) | 49(36.0) | 60(44.1) | 5(3) | 41(30.1) | 77(56.6) | 15(11.0) | 3(2.2) | 89(65.4) | 34(25.0) | 13(9.6) | ||
χ2(Z)值 | 41.523 | -7.525a | 6.649 | 12.961 | |||||||||
P值 | <0.001 | <0.001 | 0.084 | 0.002 | |||||||||
衰弱 | 咀嚼功能〔n(%)〕 | MoCA-B得分〔M(QR),分〕 | BI〔M(QR)〕 | PIM〔n( %)〕 | PIM涉及药物数量〔n(%)〕 | 神经系统类PIM〔n( %)〕 | 心血管系统类PIM〔n( %)〕 | 血液系统类PIM〔n( %)〕 | 泌尿系统类PIM〔n( %)〕 | ||||
无困难 | 有些困难 | 极度困难 | 0种 | 1种 | ≥2种 | ||||||||
否 | 71(75.5) | 16(17.0) | 7(7.4) | 15(5) | 100(0) | 26(27.7) | 68(72.3) | 20(21.3) | 6(6.4) | 2(2.1) | 11(11.7) | 14(14.9) | 4(4.3) |
是 | 59(43.4) | 44(32.4) | 33(24.3) | 14(6) | 95(15) | 110(80.9) | 26(19.1) | 43(31.6) | 67(49.3) | 29(21.3) | 54(39.7) | 59(43.4) | 27(19.9) |
χ2(Z)值 | 24.212 | -3.216a | -8.480a | 62.780 | 72.897 | 17.563 | 21.500 | 20.822 | 11.596 | ||||
P值 | <0.001 | 0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.001 |
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
年龄(岁,以60~69为参照) | 4.646 | 0.098 | ||||
70~79 | -1.132 | 0.527 | 4.611 | 0.322(0.115,0.906) | 0.032 | |
≥80 | -1.229 | 0.933 | 1.735 | 0.293(0.047,1.821) | 0.188 | |
婚姻状况(以已婚为参照) | ||||||
离异/丧偶 | 0.869 | 0.645 | 1.814 | 2.386(0.673,8.454) | 0.178 | |
经济来源(以退休金为参照) | 8.860 | 0.031 | ||||
个人储蓄 | -0.620 | 0.434 | 2.045 | 0.538(0.230,1.259) | 0.153 | |
家人给予 | 1.849 | 0.928 | 3.965 | 6.352(1.030,39.187) | 0.046 | |
抚恤金 | 1.493 | 1.605 | 0.866 | 4.452(0.192,103.452) | 0.352 | |
吸烟情况(以不吸烟为参照) | ||||||
吸烟 | -0.931 | 0.642 | 2.102 | 0.394(0.112,1.388) | 0.147 | |
握力(以实际值纳入) | -0.003 | 0.032 | 0.009 | 0.997(0.936,1.062) | 0.925 | |
SPPB评估结果(以良好为参照) | 0.838 | 0.658 | ||||
中等 | 0.348 | 0.444 | 0.615 | 1.416(0.593,3.381) | 0.433 | |
差 | 0.599 | 0.763 | 0.617 | 1.820(0.408,8.119) | 0.432 | |
CCI(以实际值纳入) | 0.268 | 0.146 | 3.382 | 1.307(0.983,1.739) | 0.066 | |
听力状况(以无困难为参照) | 1.446 | 0.485 | ||||
有些困难 | 0.677 | 0.565 | 1.440 | 1.969(0.651,5.952) | 0.230 | |
极度困难 | 0.054 | 1.527 | 0.001 | 1.055(0.053,21.050) | 0.972 | |
咀嚼功能(以无困难为参照) | 1.698 | 0.428 | ||||
有些困难 | 0.513 | 0.491 | 1.090 | 1.670(0.638,4.376) | 0.296 | |
极度困难 | 0.736 | 0.703 | 1.096 | 2.087(0.526,8.271) | 0.295 | |
MoCA-B得分(以实际值纳入) | 0.045 | 0.063 | 0.496 | 1.046(0.923,1.184) | 0.481 | |
BI(以实际值纳入) | -0.098 | 0.040 | 5.818 | 0.907(0.838,0.982) | 0.016 | |
PIM涉及药物数量(种,以0为参照) | 17.146 | <0.001 | ||||
1 | 1.524 | 0.449 | 11.503 | 4.591(1.903,11.076) | 0.001 | |
≥2 | 2.181 | 0.628 | 12.077 | 8.859(2.589,30.321) | 0.001 |
Table 2 Logistic regression analysis of the association of the number of PIM with frailty in older adults with MCI in the community
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
年龄(岁,以60~69为参照) | 4.646 | 0.098 | ||||
70~79 | -1.132 | 0.527 | 4.611 | 0.322(0.115,0.906) | 0.032 | |
≥80 | -1.229 | 0.933 | 1.735 | 0.293(0.047,1.821) | 0.188 | |
婚姻状况(以已婚为参照) | ||||||
离异/丧偶 | 0.869 | 0.645 | 1.814 | 2.386(0.673,8.454) | 0.178 | |
经济来源(以退休金为参照) | 8.860 | 0.031 | ||||
个人储蓄 | -0.620 | 0.434 | 2.045 | 0.538(0.230,1.259) | 0.153 | |
家人给予 | 1.849 | 0.928 | 3.965 | 6.352(1.030,39.187) | 0.046 | |
抚恤金 | 1.493 | 1.605 | 0.866 | 4.452(0.192,103.452) | 0.352 | |
吸烟情况(以不吸烟为参照) | ||||||
吸烟 | -0.931 | 0.642 | 2.102 | 0.394(0.112,1.388) | 0.147 | |
握力(以实际值纳入) | -0.003 | 0.032 | 0.009 | 0.997(0.936,1.062) | 0.925 | |
SPPB评估结果(以良好为参照) | 0.838 | 0.658 | ||||
中等 | 0.348 | 0.444 | 0.615 | 1.416(0.593,3.381) | 0.433 | |
差 | 0.599 | 0.763 | 0.617 | 1.820(0.408,8.119) | 0.432 | |
CCI(以实际值纳入) | 0.268 | 0.146 | 3.382 | 1.307(0.983,1.739) | 0.066 | |
听力状况(以无困难为参照) | 1.446 | 0.485 | ||||
有些困难 | 0.677 | 0.565 | 1.440 | 1.969(0.651,5.952) | 0.230 | |
极度困难 | 0.054 | 1.527 | 0.001 | 1.055(0.053,21.050) | 0.972 | |
咀嚼功能(以无困难为参照) | 1.698 | 0.428 | ||||
有些困难 | 0.513 | 0.491 | 1.090 | 1.670(0.638,4.376) | 0.296 | |
极度困难 | 0.736 | 0.703 | 1.096 | 2.087(0.526,8.271) | 0.295 | |
MoCA-B得分(以实际值纳入) | 0.045 | 0.063 | 0.496 | 1.046(0.923,1.184) | 0.481 | |
BI(以实际值纳入) | -0.098 | 0.040 | 5.818 | 0.907(0.838,0.982) | 0.016 | |
PIM涉及药物数量(种,以0为参照) | 17.146 | <0.001 | ||||
1 | 1.524 | 0.449 | 11.503 | 4.591(1.903,11.076) | 0.001 | |
≥2 | 2.181 | 0.628 | 12.077 | 8.859(2.589,30.321) | 0.001 |
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
年龄(岁,以60~69为参照) | 4.495 | 0.106 | ||||
70~79 | -1.073 | 0.524 | 4.185 | 0.342(0.122,0.956) | 0.041 | |
≥80 | -1.444 | 0.943 | 2.341 | 0.236(0.037,1.500) | 0.126 | |
婚姻状况(以已婚为参照) | ||||||
离异/丧偶 | 0.799 | 0.631 | 1.606 | 2.223(0.646,7.653) | 0.205 | |
经济来源(以退休金为参照) | 7.871 | 0.049 | ||||
个人储蓄 | -0.628 | 0.445 | 1.989 | 0.534(0.223,1.277) | 0.158 | |
家人给予 | 1.771 | 0.943 | 3.527 | 5.879(0.926,37.338) | 0.060 | |
抚恤金 | 1.180 | 1.531 | 0.594 | 3.255(0.162,65.482) | 0.441 | |
吸烟情况(以不吸烟为参照) | ||||||
吸烟 | -0.685 | 0.625 | 1.201 | 0.504(0.148,1.716) | 0.273 | |
握力(以实际值纳入) | 0.013 | 0.034 | 0.148 | 1.013(0.949,1.082) | 0.700 | |
SPPB评估结果(以良好为参照) | 1.217 | 0.544 | ||||
中等 | 0.303 | 0.448 | 0.457 | 1.354(0.563,3.257) | 0.499 | |
差 | 0.844 | 0.780 | 1.170 | 2.325(0.504,10.727) | 0.279 | |
CCI(以实际值纳入) | 0.299 | 0.139 | 4.615 | 1.348(1.027,1.771) | 0.032 | |
听力状况(以无困难为参照) | 0.765 | 0.682 | ||||
有些困难 | 0.487 | 0.576 | 0.716 | 1.628(0.527,5.030) | 0.398 | |
极度困难 | 0.488 | 1.490 | 0.107 | 1.629(0.088,30.220) | 0.743 | |
咀嚼功能(以无困难为参照) | 3.302 | 0.192 | ||||
有些困难 | 0.801 | 0.494 | 2.630 | 2.227(0.846,5.861) | 0.105 | |
极度困难 | 0.889 | 0.728 | 1.490 | 2.432(0.584,10.135) | 0.222 | |
MoCA-B得分(以实际值纳入) | 0.027 | 0.066 | 0.170 | 1.028(0.903,1.169) | 0.680 | |
BI(以实际值纳入) | -0.092 | 0.041 | 5.087 | 0.913(0.843,0.988) | 0.024 | |
神经系统类PIM(以无为参照) | ||||||
有 | 1.670 | 0.846 | 3.894 | 5.310(1.011,27.877) | 0.048 | |
心血管系统类PIM(以无为参照) | ||||||
有 | 1.134 | 0.497 | 5.199 | 3.108(1.173,8.241) | 0.023 | |
血液系统类PIM(以无为参照) | ||||||
有 | 0.799 | 0.469 | 2.906 | 2.224(0.887,5.573) | 0.088 | |
泌尿系统类PIM(以无为参照) | ||||||
有 | 20.396 | 6 944.907 | <0.001 | 721 190 309.184 | 0.998 |
Table 3 Logistic regression analysis of the association of types of PIM with frailty in older adults with MCI in the community
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
年龄(岁,以60~69为参照) | 4.495 | 0.106 | ||||
70~79 | -1.073 | 0.524 | 4.185 | 0.342(0.122,0.956) | 0.041 | |
≥80 | -1.444 | 0.943 | 2.341 | 0.236(0.037,1.500) | 0.126 | |
婚姻状况(以已婚为参照) | ||||||
离异/丧偶 | 0.799 | 0.631 | 1.606 | 2.223(0.646,7.653) | 0.205 | |
经济来源(以退休金为参照) | 7.871 | 0.049 | ||||
个人储蓄 | -0.628 | 0.445 | 1.989 | 0.534(0.223,1.277) | 0.158 | |
家人给予 | 1.771 | 0.943 | 3.527 | 5.879(0.926,37.338) | 0.060 | |
抚恤金 | 1.180 | 1.531 | 0.594 | 3.255(0.162,65.482) | 0.441 | |
吸烟情况(以不吸烟为参照) | ||||||
吸烟 | -0.685 | 0.625 | 1.201 | 0.504(0.148,1.716) | 0.273 | |
握力(以实际值纳入) | 0.013 | 0.034 | 0.148 | 1.013(0.949,1.082) | 0.700 | |
SPPB评估结果(以良好为参照) | 1.217 | 0.544 | ||||
中等 | 0.303 | 0.448 | 0.457 | 1.354(0.563,3.257) | 0.499 | |
差 | 0.844 | 0.780 | 1.170 | 2.325(0.504,10.727) | 0.279 | |
CCI(以实际值纳入) | 0.299 | 0.139 | 4.615 | 1.348(1.027,1.771) | 0.032 | |
听力状况(以无困难为参照) | 0.765 | 0.682 | ||||
有些困难 | 0.487 | 0.576 | 0.716 | 1.628(0.527,5.030) | 0.398 | |
极度困难 | 0.488 | 1.490 | 0.107 | 1.629(0.088,30.220) | 0.743 | |
咀嚼功能(以无困难为参照) | 3.302 | 0.192 | ||||
有些困难 | 0.801 | 0.494 | 2.630 | 2.227(0.846,5.861) | 0.105 | |
极度困难 | 0.889 | 0.728 | 1.490 | 2.432(0.584,10.135) | 0.222 | |
MoCA-B得分(以实际值纳入) | 0.027 | 0.066 | 0.170 | 1.028(0.903,1.169) | 0.680 | |
BI(以实际值纳入) | -0.092 | 0.041 | 5.087 | 0.913(0.843,0.988) | 0.024 | |
神经系统类PIM(以无为参照) | ||||||
有 | 1.670 | 0.846 | 3.894 | 5.310(1.011,27.877) | 0.048 | |
心血管系统类PIM(以无为参照) | ||||||
有 | 1.134 | 0.497 | 5.199 | 3.108(1.173,8.241) | 0.023 | |
血液系统类PIM(以无为参照) | ||||||
有 | 0.799 | 0.469 | 2.906 | 2.224(0.887,5.573) | 0.088 | |
泌尿系统类PIM(以无为参照) | ||||||
有 | 20.396 | 6 944.907 | <0.001 | 721 190 309.184 | 0.998 |
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